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Application of gingko extract nanometer liposome in gynecological disease treatment

A technology of ginkgo extract and nano-liposome, which is applied in the field of biomedicine, can solve the problems that have not yet been reported on the application of ginkgo extract nano-liposome, and achieve the effect of safe use, no side effects, and significant therapeutic effect

Inactive Publication Date: 2014-04-30
王青
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no report on the application of ginkgo extract nanoliposomes in the treatment of gynecological diseases

Method used

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  • Application of gingko extract nanometer liposome in gynecological disease treatment
  • Application of gingko extract nanometer liposome in gynecological disease treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Peel the ginkgo nuts and crush them in a tissue grinder. Accurately weigh a certain amount of crushed ginkgo fruit, add 80% ethanol with a solid-to-liquid ratio of 1:10 (W / V), and stir and extract twice at a water bath temperature of 60°C, each extraction time is 4 hours. After the leaching, centrifuge (5000 rpm, 15 minutes), and take the supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain Ginkgo biloba extract. The properties are: light yellow extract, soluble in Alcohol, insoluble in water.

[0020] Phospholipid absolute ethanol solution, filter; add the above-mentioned ginkgo extract extract, vitamin E, shake evenly, put in a round bottom flask, 30 ℃ water bath constant temperature rotary evaporation, reduce pressure to form a film, so that the film material is uniformly formed on the bottle wall Add PBS buffer...

Embodiment 2

[0023] Peel the ginkgo nuts and crush them in a tissue grinder. Accurately weigh a certain amount of crushed ginkgo fruit, add distilled water with a solid-to-liquid ratio of 1:10 (W / V), and stir and extract twice at a water bath temperature of 60°C, each extraction time is 4 hours. After the leaching, centrifuge (5000 rpm, 15 minutes), and take the supernatant. Concentrate the supernatant, and dry it under vacuum at 60°C to obtain the ginkgo extract. The properties are: light yellow extract, soluble in alcohol, insoluble in water.

[0024] Ginkgo extract nanoliposome suspension was prepared according to the preparation process of Ginkgo extract nanoliposome suspension in Example 1.

[0025] Preparation of the gel: Sprinkle 10 g of Carbopol on the surface of 500 ml of distilled water, and swell overnight. Weigh 60 g of glycerin and 120 ml of propylene glycol, respectively add them to the swollen Carbopol, and grind them evenly to obtain a transparent gel matrix. Take 40ml o...

Embodiment 3

[0027] Peel the ginkgo nuts and crush them in a tissue grinder. Accurately weigh a certain amount of crushed ginkgo fruit, add 80% petroleum ether with a solid-liquid ratio of 1:10 (W / V), and stir and extract twice at a water bath temperature of 60°C, each extraction time is 4 hours. After the leaching, centrifuge (5000 rpm, 15 minutes), and take the supernatant. Concentrate the supernatant with a vacuum rotary evaporator under the conditions of temperature 55°C, pressure 0.008-0.009MPa, concentrate under reduced pressure, and vacuum-dry at 60°C to obtain Ginkgo biloba extract. The properties are: light yellow extract, soluble in Alcohol, insoluble in water.

[0028] Ginkgo extract nanoliposome suspension was prepared according to the preparation process of Ginkgo extract nanoliposome suspension in Example 1.

[0029] Preparation of ointment: Take 5ml of the above-mentioned ginkgo extract nanoliposome suspension, dissolve it in 100ml of 95% ethanol solution, add 50ml of trie...

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Abstract

The invention relates to a use of gingko extract nanometer liposome in preparation of external application preparations for gynecological disease treatment. According to the present invention, the gingko extract can be obtained from extracts of leaf, fruit, rhizome and other parts of gingko through a chemical separation method; the gingko extract nanometer liposome is prepared by using a film ultrasound-high pressure homogenization method; the drug, the cosmetic or the disinfectant external application preparation containing the gingko extract nanometer liposome and provided for gynecological disease treatment contains 0.001-80% of the gingko extract nanometer liposome and a pharmaceutically and commonly used external application preparation substrate or an acceptable carrier; the preparation is the any one external application formulation in the pharmacy; and results of pharmacology studies and clinical trials show that the gingko extract nanometer liposome provides significant treatment effects for a variety of gynecological diseases, and has characteristics of safe use and no side effect.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to the use of ginkgo extract nano liposomes in preparing external preparations for treating gynecological diseases. Background technique [0002] Gynecological diseases such as trichomonal vaginitis, fungal vaginitis, bacterial vaginosis, genital pruritus, cervicitis, cervical erosion, etc., are one of the most common clinical diseases. Such diseases last for a long time and are prone to repeated attacks. Bring misery to patient, have a strong impact on patient's physical and mental health. At present, most of these diseases are treated with antimicrobial drugs. Although these drugs have temporary effects, they are prone to relapse after drug withdrawal and cannot achieve the effect of repairing wounds; and long-term use will cause many side effects. In order to avoid the occurrence of such adverse phenomena, the market needs to develop an external preparation for t...

Claims

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Application Information

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IPC IPC(8): A61K36/16A61K9/127A61P15/00A61P15/02A61P31/04A61P31/10A61P31/20A61P33/02
Inventor 雷红王青
Owner 王青
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