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The application and detection tool of using adipsin as a marker to prepare detection tools

A technology for detecting tools and markers, used in measurement devices, biological material analysis, instruments, etc.

Active Publication Date: 2017-05-31
ORIGISSAY BIOLOGICS TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, most of the existing preeclampsia detection tools that have been published are more effective in detecting severe preeclampsia patients, with better sensitivity and specificity, which can reach 90% and 80%; but for mild preeclampsia patients, Its detection effect usually only reaches 80% sensitivity and specificity

Method used

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  • The application and detection tool of using adipsin as a marker to prepare detection tools
  • The application and detection tool of using adipsin as a marker to prepare detection tools

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preeclampsia group: 124 pregnant women with preeclampsia;

[0035] Healthy control group: 135 healthy pregnant women.

[0036] Clinical screening criteria for experimental subjects:

[0037] Preeclampsia group - (i) systolic blood pressure ≥ 140mmHg;

[0038] (ii) diastolic blood pressure ≥ 90mmHg;

[0039] (iii) Protein excretion ≥300 mg in a 24-hour urine collection, or dipstick ≥2+.

[0040] Healthy control group - (i) systolic blood pressure <140mmHg;

[0041] (ii) Diastolic blood pressure <90mmHg;

[0042] (iii) Protein excretion <300 mg in 24-hour urine collection, or dipstick <2+.

[0043] The age distribution of the subjects: the average age of 124 pregnant women in the preeclampsia group was 28 years old (age range 19-35 years old), and the average age of the healthy control group was 30 years old (age range 18-43 years old).

[0044] Sample collection method: take urine samples from each experimental group.

[0045]A. Experimental method: qualitative de...

Embodiment 2

[0092] The comparative examples 1-4 preeclampsia qualitative detection tools obtained by different methods were respectively used to detect the clinical samples of the urine of pregnant women in Example 1, including the preeclampsia group and the healthy control group, wherein the preeclampsia group The 124 cases were divided into severe preeclampsia group (sPE, screening criteria: systolic blood pressure ≥ 160mmHg, diastolic blood pressure ≥ 110mmHg, proteinuria > 5g / 24 hours) according to the size of systolic and diastolic blood pressure and proteinuria in 24 hours. 54 cases and Mild preeclampsia group (mPE, systolic blood pressure ≥ 140mmHg, diastolic blood pressure ≥ 90mmHg, protein excretion ≥ 300mg in 24 hours of urine collection) 70 cases. The healthy control group was 135 cases.

[0093] Sample Collection: A urine sample is taken from a pregnant woman.

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Abstract

The invention discloses application of a prepared tool for detecting corresponding diseases by using a detection marker of preeclampsia suffered by a pregnant woman, namely preeclampsia diseases, as well as corresponding detection tools obtained through the application mode and in particular relates to application by taking Adipsin as a marker for preparing a detection tool of preeclampsia and corresponding detection tools obtained through the application mode. By adoption of the application of taking Adipsin as the marker for preparing a detection tool of preeclampsia, the detection tool is a qualitative detection tool, the detection object of the detection tool is urine of pregnant women, and the detection limit concentration of Adipsin is 10.5-11.5ng / mL. According to the application mode, detection tools, such as kits or rapid detection tools, of which the sensitivity and specificity for detecting mild preeclampsia diseases reach 90% and 80% can be obtained.

Description

technical field [0001] The present invention relates to the application of detection markers that can be used as detection markers for pre-eclampsia, that is, pre-eclampsia disease that pregnant women suffer from, to the preparation of detection tools for corresponding diseases and the corresponding detection tools obtained through this application; specifically, Adipsin is used as a marker The application of preparing preeclampsia detection tools and the corresponding detection tools obtained through the application. Background technique [0002] Hypertension is the most common medical problem encountered during pregnancy, complicating 2-3% of pregnancies. Hypertensive disorders during pregnancy were classified into 4 categories: 1. Chronic hypertension; 2. Preeclampsia; 3. Preeclampsia plus chronic hypertension; and 4. Pregnancy or gestational hypertension. Chronic hypertension is defined as blood pressure above 140 / 90 mmHg before pregnancy or before 20 weeks of gestation...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/558
CPCG01N33/558G01N33/689G01N2800/368
Inventor 关祥乾胡怀忠
Owner ORIGISSAY BIOLOGICS TECH