Drug for treatment of vertigo and preparation method thereof
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A technology of medicine and capsule, which is applied in the field of medicine for treating vertigo and its preparation, and achieves the effects of good reproducibility, reducing the wet weight of thrombus, and prolonging the latency period of motion sickness
Inactive Publication Date: 2014-05-14
WUHAN UNIV OF TECH
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Problems solved by technology
However, at present, the fingerprints of traditional Chinese medicines often only involve the study of single medicinal materials or single preparations, and the research on the fingerprints of Chinese patent medicine compound preparations composed of a variety of Chinese medicinal materials is still in its infancy.
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Embodiment 1
[0042] Example 1 Preparation method of compound Yuntong capsule for treating dizziness
[0043] (1) Ingredients: 2-3 parts of Scutellaria baicalensis, 1-2 parts of Bupleurum, 1-2 parts of Pinellia ternata, 1-2 parts of Codonopsis, 1 part of licorice, 1-2 parts of dried tangerine peel, 1-2 parts of Alisma, Baizhu 2-3 parts, Poria cocos 2-3 parts, Tianma 1-2 parts, Chrysanthemum 1-2 parts, Uncaria 2-3 parts, Shichangpu 2-3 parts, Panax notoginseng 1-2 parts, Leech 1-2 parts, 2-4 servings of Pueraria.
[0044] (2) Extraction: Add ethanol with a volume concentration of 75%, equivalent to 8 times its weight in grams, in milliliters, and extract at 60°C for 2.5 hours to obtain the first extract of the drug of the present invention , Filter; Perform the second extraction according to the same method, filter, and combine the extracts.
[0045] (3) The extract is heated and concentrated to 1 / 15 of the total volume on a rotary evaporator at a temperature of 55°C to obtain a concentrated solu...
Embodiment 2
[0046] Example 2 The quality control method of compound Yuntong capsules for treating vertigo
[0047] (1) Preparation of reference solution: take 60mg of baicalin reference substance dried under reduced pressure at 60℃ for 4 hours, accurately weigh about 6mg of baicalin reference substance, put it in a 100mL volumetric flask, add a small amount of methanol to dissolve, then add methanol Reach the mark, shake well, and ultrasound for 20 minutes.
[0048] (2) Preparation of the drug sample solution of the present invention: accurately weigh 0.4g of the content of the drug capsule of the present invention, place it in a 100mL volumetric flask, add a small amount of methanol to dissolve, then add methanol to the mark, shake well, ultrasound for 45min, and leave it for 3min , Take the supernatant, filter it with a microporous membrane (0.45μm) and place it in a centrifuge tube to obtain sample solution 1. The same method prepares 6 batches of the drug sample solution of the present inv...
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Abstract
The invention discloses a vertigo treatment drug compound Yuntong and its preparation process and quality control method. The bulk drugs include: scutellaria, radix bupleuri, Rhizoma Pinellinae Praeparata, Codonopsis pilosula, liquorice, tangerine peel, rhizoma alismatis, bighead atractylodes rhizome, poria, Gastrodia elata, chrysanthemum, Uncaria tomentosa, acorus gramineus, panax notoginseng, leech, and radix puerariae. The preparation method comprises: conducting ethanol reflux extraction on the bulk drugs; concentrating the extracted solution, carrying out drying, crushing and sieving, adding soluble starch and microcrystalline cellulose, mixing the materials evenly, performing granulating and capsule filling, thus obtaining the compound Yuntong capsule. The invention also relates to establishment of a standard fingerprint spectrum, establishment of a test sample fingerprint spectrum and comparison of the two spectrums. The fingerprint spectrum of the drug shows 17 main chromatographic peaks at the place of 283nm, and the chemical structure of one chromatographic peak therein can be determined as baicalin, and baicalin can be chosen as an index component to perform content determination. The method has the advantages of good precision, stability and reproducibility, can be used for quality control of the drug and preparations provided by the invention, and provides reference for clinical application choice.
Description
Technical field [0001] The invention relates to a capsule for treating vertigo, in particular to a medicament for treating vertigo, a preparation method and a quality control method thereof. Background technique [0002] Dizziness is a common clinical syndrome, which is more common in middle-aged and elderly people, but also in young people. The disease can recur and hinder normal work and life. In severe cases, it can develop into stroke, syndrome or loss of syndrome and endanger life. Western medicines such as sibilene are mostly used to treat vertigo. However, chemical medicines generally have large toxic and side effects, irritating other parts of the body and organs, and are prone to repeated attacks, so they are not suitable for long-term use. Clinically, Chinese medicine is used to prevent and treat vertigo, which has a good effect on controlling the occurrence and development of vertigo. In the present invention, a compound Yuntong capsule for treating vertigo is studie...
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