Ganoderma sinense polysaccharide tablet and preparation method thereof

A technology for tablets and polysaccharides, applied in the field of medicine, can solve the problems of slow disintegration of Zizhi polysaccharide tablets, unable to meet the needs of treatment, moisture absorption, etc., and achieve the effects of good long-term storage stability, definite therapeutic effect, and long application history.

Active Publication Date: 2014-05-28
江西泽众制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology improves upon previous methods used during manufacturing but still faces challenges like poor water solubility due to expensive ingredient(s) added into the formulation without affecting its overall quality level negatively impacted their ability to deliver effective medications over time.

Problems solved by technology

This patented technical problem addressed in this patents relates to reducing the severity of bacteremia associated with cancer treatments like chemo-, radioactive rays, and radiation. Current methods involve administering antibiotic agents before or during an illumination procedure, increasing risk factors related to these procedures. Therefore there exists a demand for improved ways to reduce bacteamicroscopy induced injuries while maintaining effective antiinflammatories without causing negative reactions.

Method used

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  • Ganoderma sinense polysaccharide tablet and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of Zizhi polysaccharide powder:

[0032] Wash the Zizhi fruiting body and / or mycelium, drain, add water and decoct twice, decoct for 2 hours for the first time, filter the medicinal liquid with a 100-mesh filter cloth, add 5 times the amount of water to the dregs for the second The second decoction for 2 hours, the medicinal liquid was filtered with a 100-mesh filter cloth, the medicinal liquid obtained from the second decoction was combined, and concentrated under reduced pressure to a clear paste with a relative density of 1.15 (heat measurement at 50°C), and 95% Ethanol until the alcohol content reaches 62%, let it stand for 24 hours, take the supernatant to recover the ethanol until it has no alcohol smell, and the precipitate after recovering the ethanol is vacuum-dried at 60°C, and the moisture content of the dry extract is controlled within 3%. Put the paste into a high-efficiency pulverizer and pulverize it into fine powder, and pass through a 100-me...

Embodiment 2

[0034] prescription:

[0035] .

[0036] Preparation:

[0037] Weigh Zizhi polysaccharide powder, starch and dextrin according to the prescription, and mix them evenly; use 30% ethanol solution to make a soft material from the mixture, and pass through a 16-mesh sieve to granulate; dry the wet granules at 60°C, so that the water content of the granules is 3.0%; Pass the dried granules through a 14-mesh sieve for granulation; add magnesium stearate to the granulated granules, mix well, and press into tablets.

[0038]

Embodiment 3

[0040] prescription:

[0041] .

[0042] Preparation:

[0043] Weigh Zizhi polysaccharide powder, starch, dextrin and sucrose according to the prescription, and mix them evenly; use 40% ethanol solution to make a soft material from the mixture, and pass through a 18-mesh sieve to granulate; dry the wet granules at 70°C, so that the water content of the granules is 3.2 %; pass the dried granules through a 16-mesh sieve for granulation; add magnesium stearate to the granules of the granules, mix well, and press into tablets.

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Abstract

The invention relates to a ganoderma sinense polysaccharide tablet and a preparation method thereof. The ganoderma sinense polysaccharide tablet comprises the following components in parts by weight: 200 to 300 parts of ganoderma sinense polysaccharide, 30 to 60 parts of dextrin, 30 to 60 parts of starch and 0.5 to 2.0 parts of magnesium stearate. According to the invention, the low-price dextrin and starch, and the like are used as the main auxiliary materials; thus, the good properties of the tablet are achieved, such as high disintegration speed, small weight difference, controllable dosage and high stability in long term storage, and the technical problem of sticking during brewing is solved. The prepared ganoderma sinense polysaccharide tablet can be used for treating diseases of neurasthenia, thrombocytopenia, leukopenia, hemopoiesis injury caused by ionizing radiation and occupation, and hypoleucocytosis after chemotherapy or radiotherapy of cancer patients, and has no stimulation to human bodies as well as fewer adverse effects.

Description

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Claims

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Application Information

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Owner 江西泽众制药股份有限公司
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