Lutein water soluble powder and preparation method thereof
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A technology for water-soluble powder and lutein, applied in the field of medicine, can solve the problems of cumbersome, low water-solubility, complicated preparation methods, etc., and achieve the effects of expanding the scope of application, uniform and lasting color, and good fluidity
Active Publication Date: 2014-06-18
GUANGZHOU NEWORLD PHARMA CO LTD
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[0005] However, lutein is insoluble in water and slightly soluble in oil. In addition, lutein itself is easily oxidized, so the bioavailability of lutein crystals is very low. These characteristics determine the application of lutein crystals. In addition, the lutein water-soluble powder prepared in the prior art has the disadvantages of low water solubility, poor stability, complicated preparation method and loaded down with trivial details
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Embodiment 1
[0030] A preparation method of lutein water-soluble powder, comprising the following steps:
[0031] (1) Mix 5g of lutein, 35g of polyvinylpyrrolidone K30, 10g of Tween-80 and 1g of α-tocopherol, and dissolve in 100g of ethyl acetate in a water bath at 50°C: absolute ethanol (w / w)=1: 1 in a mixed solvent;
[0032] (2) Spray-dry and evaporate the solvent to obtain lutein water-soluble powder. The spray drying condition is set to the air inlet flow rate of 48m 3 / h, spray pressure 2.5bar, liquid inlet pump speed 2.0r / s, control outlet air temperature to about 40°C.
Embodiment 2
[0034] A preparation method of lutein water-soluble powder, comprising the following steps:
[0035] (1) Mix 10g of 72% lutein, 100g of polyethylene glycol 2000, 20g of Span-80 and 2g of α-tocopherol, and dissolve in 200g of ethyl acetate in a water bath at 40°C: absolute ethanol (w / w) = 1:4 mixed solvent;
[0036] (2) Spray-dry and evaporate the solvent to obtain lutein water-soluble powder. The spray drying condition is set to the air inlet flow rate of 60m 3 / h, spray pressure 2.0bar, liquid inlet pump speed 1.8r / s, control outlet air temperature to about 45°C.
Embodiment 3
[0038] A preparation method of lutein water-soluble powder, comprising the following steps:
[0039] (1) Take 5g of 80% lutein, 75g of polyvinylpyrrolidone K30, 20g of Span-80 and 2g of ascorbic acid, and dissolve them in 150g of ethyl acetate: anhydrous ethanol (w / w) = 4:1 mixed solvent in a water bath at 50°C middle;
[0040] (2) Spray-dry and evaporate the solvent to obtain lutein water-soluble powder. The spray drying condition is set to the air inlet flow rate of 52m 3 / h, spray pressure 2.0bar, liquid inlet pump speed 2.5r / s, control outlet air temperature at 38°C-40°C.
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Abstract
The invention discloses lutein water soluble powder and a preparation method thereof. The preparation method comprises the following steps: dissolving lutein, a water soluble carrier, a surfactant and an additive into an organic solvent at a weight ratio of 1:(5-20):(1-5):(0-3) under the condition of 20-60 DEG C; spray-drying so as to remove the organic solvent after the components are totally dissolved. Based on a lot of experiments and research made by the inventor, the optimal technological parameters of the lutein water soluble powder are obtained by using the spray drying method for preparation, and the optimal raw materials for preparing the water soluble powder and the ratio of the raw materials are determined; the method is simple, economical and practical, is easily operated, and is suitable for large-scale production; the lutein water soluble powder prepared according to the method has high water solubility, high stability, homogeneous color and good fluidity, has the solubility of 95 percent above in water, and can be widely used in the fields of food, medicines and the like, so that the application range of lutein is greatly enlarged.
Description
technical field [0001] The invention belongs to the field of medical science and technology, and in particular relates to a water-soluble lutein powder and a preparation method thereof. Background technique [0002] Lutein, also known as "plant lutein" (see formula Ⅰ for the structural formula), is a natural pigment widely present in vegetables, flowers, fruits and some algal organisms. As early as 1995, the US FDA Approved for use in food and beverages as a dietary supplement. Lutein has good effects in preventing human aging, age-related macular degeneration, cataract, etc., so it is very popular in the US market. In the international market, the price of 1 gram of lutein is equivalent to 1 gram of gold, so people call it "plant gold". [0003] [0004] As a carotenoid, lutein is an excellent natural antioxidant and non-toxic natural yellow pigment. It not only has strong coloring power, but also strengthens the nutritional value of added foods, especially lutein and ...
Claims
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