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Lung-targeted nano-liposome composition as well as preparation method and application thereof
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A technology of nano-liposome and composition, applied in the field of medicine and targeted immunoliposome, can solve problems such as restricting the development of traditional Chinese medicine, and achieve the effect of uniform size
Active Publication Date: 2014-06-18
卢凯华
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Problems solved by technology
There is no related liposome report for the more effective prescription extracts in traditional Chinese medicine, let alone specific lung-targeting nano-liposome compositions, which greatly limits the development of traditional Chinese medicine in the field of liposomes
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Embodiment 1
[0036] Mix 30 parts of raw Astragalus membranaceus, 12 parts of raw Atractylodes macrocephala, 12 parts of North Radix Ginseng, 30 parts of Hedyotis diffusa, 15 parts of Chanyi, 15 parts of Shandougen, 12 parts of Asparagus, 30 parts of raw Nanxing, 30 parts of raw oyster, Fifteen parts of Gualoupi, 30 parts of Shijianchuan, and 30 parts of Shishangbai were decocted with water three times, and the decoction liquids were combined to obtain the water extract of the traditional Chinese medicine composition.
[0039] Thirty nude mice were purchased from the Shanghai Experimental Animal Center of the Chinese Academy of Sciences, half male and half male, weighing 16-20 g, aged 6-8 weeks.
[0040] LAX-83 human lungadenocarcinoma cells (purchased from the Institute of Materia Medica, Shanghai Branch of the Chinese Academy of Sciences) were inoculated subcutaneously in the right axilla of each nude mouse, and used according to Liu Quanzhang, Human Chromosome Methodology (People's Health Publishing) Society, 1992:55-61) for identification.
[0041] The inoculated nude mice were randomly divided into 3 groups, 10 in each group, half male and half male.
[0042] (1) The blank tumor-bearing control group was administered with 0.2ml of normal saline for 21 days.
[0043] (2) Chinese medicine extract group, the aqueous extract of the Chinese medicine composition obtained in Example 1 was concentrated by vacuum rotary evaporation to co...
Embodiment 3
[0050] 1. Prepare the lung-targeted nanoliposome composition according to the following method
[0051] (1) Obtaining the extract composition of traditional Chinese medicine,
[0052] Mix 30 parts of raw Astragalus membranaceus, 12 parts of raw Atractylodes macrocephala, 12 parts of North Radix Ginseng, 30 parts of Hedyotis diffusa, 15 parts of Chanyi, 15 parts of Shandougen, 12 parts of Asparagus, 30 parts of raw Nanxing, 30 parts of raw oyster, Fifteen parts of Gualoupi, 30 parts of Shijianchuan, and 30 parts of Shishangbai were decocted with water three times, the decoction liquid was combined, the water liquid was removed by vacuum rotary evaporation, and the water extract of the Chinese medicine prescription was obtained;
[0053] Place in a vacuum constant temperature drying oven overnight to obtain a traditional Chinese medicine extract composition;
[0054] (2) Dissolve phospholipids, cholesterol and antioxidants in organic solvents, remove the organic solvents by vac...
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Abstract
The invention belongs to the field of medicines, particularly relates to the field of targeted nano-liposomes, and more specifically relates to a lung-targeted nano-liposome composition as well as a preparation method and application thereof. The invention creatively discloses the lung-targeted nano-liposome composition for the blank of the existing traditional Chinese medicine formulas in the liposome filed. The lung-targeted nano-liposome composition comprises a special lung texture targeting agent, a traditional Chinese medicine extract composition and a nano-liposome, wherein the special lung texture targeting agent is lung surface active protein A, the nano-liposome consists of phospholipid, cholesterol and an anti-oxidant; the traditional Chinese medicine extract composition is an aqueous extract of the following composition medicine materials. The obtained lung-targeted nano-liposome composition which is almost uniform in size and spherical in shape has a mean grain size of 100nm-150nm and encapsulation efficiency of about 84%, overcomes a difficult problem that the traditional Chinese medicine composition is difficult to prepare into a liposome dosage form, and develops a wider prospect for applying the traditional Chinese medicine formula.
Description
technical field [0001] The invention belongs to the field of medicine, in particular relates to the field of targeted immune liposome, more specifically relates to the lung-targeted nano liposome and its preparation method and application. Background technique [0002] Targeting nanoliposomes, especially active targeting nanoliposomes, can also be called immunoliposomes, or body-modified liposomes, and their mechanism of action is: monoclonal antibodies (also known as monoclonal antibodies or ligands) Coupling with specific liposomes to construct immunoliposomes, the liposomes are specifically combined with target cellantigen-antibodies through monoclonal antibodies, and can target liposomes to specific cells and organs. [0003] The liposome itself is made into nano-liposome, due to the intervention of nanotechnology, it also has the beneficial effect of increasing drugsolubility, bioavailability and drug targeting effect brought by nanotechnology. [0004] Nano-targetin...
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