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Traditional Chinese medicinal preparation for treating chronic renal disease and preparation method thereof

A technology for chronic kidney disease and traditional Chinese medicine preparations, which is applied in pharmaceutical formulations, urinary system diseases, medical preparations containing active ingredients, etc. formulations and other issues, to achieve the effect of saving resources, simplifying the formulation properly, and reducing energy consumption

Active Publication Date: 2014-07-02
XIAN SHIJISHENGKANG PHARMA IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are reports about rhubarb extract and rhubarb preparation used alone or in combination with other drugs for the treatment of chronic renal failure, and there are also reports about safflower injection used alone or in combination with other drugs for the treatment of chronic renal failure, but the inventor There is no report on the direct compatibility of rhubarb and safflower for the treatment of chronic kidney disease and chronic renal failure, let alone the report of rhubarb and safflower made into traditional Chinese medicine preparations for the treatment of chronic kidney disease and chronic renal failure

Method used

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  • Traditional Chinese medicinal preparation for treating chronic renal disease and preparation method thereof
  • Traditional Chinese medicinal preparation for treating chronic renal disease and preparation method thereof
  • Traditional Chinese medicinal preparation for treating chronic renal disease and preparation method thereof

Examples

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Effect test

Embodiment 1

[0110] Example 1 (1) Take 3000g of rhubarb and crush it into coarse particles and 5000g of safflower, add 6 times the amount of water to soak for 15 minutes, heat and ultrasonically extract for 15 minutes for the first time, and filter; heat and ultrasonically extract for 10 minutes for the second time, filter, and combine water twice Extract the liquid, concentrate under reduced pressure to a relative density of 1.18 at 60°C, add 3% gelatin solution to remove tannin, filter, add ethanol to make the alcohol content 75%, let stand, filter, take the filtrate and concentrate under reduced pressure to a relative density of 1.18 at 60°C, recover ethanol, continue to add ethanol to make the alcohol content 80%, let it stand, filter, recover ethanol, add water for injection to 2-3 times the amount of the liquid medicine, and then add 0.3%-0.4% activated carbon, Boil for 30 minutes, filter, adjust the pH value to 7.0-7.5 to obtain rhubarb and safflower extracts, ultra-filter, adjust ...

Embodiment 2

[0112] Take 5000g of safflower and 3000g of rhubarb crushed into coarse particles, add 6 times the amount of water to decoct, combine the extracts, filter, collect the filtrate, concentrate, enter the macroporous resin column for adsorption and separation, and collect the first effluent; first elute with water , collect the eluate, and then elute with 50%-60% ethanol, collect the ethanol eluate, recover the ethanol until it has no alcohol smell, combine the effluent, concentrate under reduced pressure to a relative density of 1.21 at 60°C, add 5% gelatin Remove tannins from the solution, filter, add ethanol to make the alcohol content 75%, let stand, filter, take the filtrate and concentrate under reduced pressure to a relative density of 1.21 at 60°C, recover ethanol, continue to add ethanol to make the alcohol content 80%, Stand still, filter, recover ethanol, add water for injection to 2-3 times the amount of the liquid medicine, then add 0.3%-0.5% activated carbon, boil for...

Embodiment 3

[0114] Take 5000g of safflower and 3000g of rhubarb crushed into fine particles and put them in the extraction kettle for CO 2 Supercritical extraction, the flow rate of the supercritical fluid entering the extraction kettle is 40L / h, the extraction pressure is 25MPa, the extraction temperature is 45°C, and the extraction time is 2.5h. The rhubarb and safflower high-pressure fluids flowing out of the extraction kettle enter the separation kettle Separation, separation pressure I is 8 Mpa, separation temperature I is 30 ° C; separation pressure II is 6 Mpa, separation temperature II is 25 ° C, collect the extracts of rhubarb and safflower, add water for injection to 2-3 Double the amount, then add 0.3%-0.5% activated carbon, boil for 30 minutes, filter, adjust the pH value to 7.4-7.7, get rhubarb and safflower extract, ultra-filter, adjust the pH value to 7.4-7.7, the liquid is passed through a microporous The filter of the filter membrane is filtered, filled and sealed, and st...

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Abstract

The invention provides a traditional Chinese medicinal preparation for treating chronic renal disease and a preparation method thereof. The traditional Chinese medicinal preparation is prepared from the following crude medicines in parts by weight: rheum officinale and safflower on (1-10):(10-1); the crude medicines are prepared into an injection, a freeze-dried powder injection or other oral preparations through certain extraction and purification processes. Animal experiments prove that the traditional Chinese medicinal preparation can be used for significantly improving the hemorheology indexes of mice infected by chronic glomerulonephritis and reducing serum IL-6, IL-8 and TNF-alpha levels; the preparation can be used for remarkably reducing serum urea nitrogen and serum creatinine contents of mice of chronic renal failure and increasing a serum albumin content; moreover, the preparation can be used for improving the various hemorheology indexes and levels of mice of chronic renal failure; a pathological result shows that the traditional Chinese medicinal preparation disclosed by the invention can be used for improving and inhibiting damage of chronic kidney disease and chronic renal failure on kidney; furthermore, the traditional Chinese medicinal preparation prepared by the optimal preparation method disclosed by the invention is more excellent than a traditional Chinese medicinal preparation prepared by a conventional method.

Description

technical field [0001] The invention relates to a traditional Chinese medicine preparation, in particular to a medicine preparation for treating chronic kidney disease and chronic renal failure and a preparation method thereof. Specifically, it belongs to the field of medicine. Background technique [0002] Chronic Kidney Disease (CKD) clinically includes chronic glomerulonephritis, nephrotic syndrome, membranous nephropathy, diabetic nephropathy, hypertensive nephropathy and various secondary nephropathy, etc. The prevalence of vascular diseases is high and the mortality rate is high. In addition, the awareness rate of chronic kidney disease is low, the prevention rate is low, and the awareness rate of cardiovascular disease is low. It has become a global public health problem. Medically, CKD is diagnosed mainly from two aspects: (1) kidney damage (displaying abnormal kidney structure and function) for ≥ 3 months, with or without decreased glomerular filtration rate (GRF);...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K9/19A61P13/12A61K36/286
Inventor 曹凤君吕延英詹芳王光建赵兴王俊平
Owner XIAN SHIJISHENGKANG PHARMA IND
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