Preparation method of methylamphetamine-resistant egg yolk antibody

A methamphetamine and egg yolk antibody technology, applied in chemical instruments and methods, from egg immunoglobulins, peptides, etc., can solve the problem of lack of specific treatment drugs for methamphetamine, and reduce addiction and relapse behavior , low cost, and the effect of reducing toxicity

Active Publication Date: 2014-07-02
JIANGHAN UNIVERSITY
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In order to solve the problem of lack of specific therapeutic drugs against methamphetamine in the prior art, the embodiment of the present invention provides a preparation method of egg yolk antibody against methamphetamine

Method used

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  • Preparation method of methylamphetamine-resistant egg yolk antibody
  • Preparation method of methylamphetamine-resistant egg yolk antibody
  • Preparation method of methylamphetamine-resistant egg yolk antibody

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0034] One, the preparation of methamphetamine-bovine serum albumin antigen

[0035] 1 Synthesis and identification of hapten

[0036] The hapten can be combined with the corresponding antibody to form an antigen-antibody, and the hapten cannot alone stimulate the human or animal body to produce antibodies.

[0037] 1.1 Synthesis

[0038] Weigh 150mg of methamphetamine hydrochloride and dissolve it in 150mg of distilled water, add dropwise a NaOH solution with a concentration of 1mol / L until the free form of methamphetamine is separated out, extract with chloroform (analytical grade), and extract the product with NaOH 2 SO 4drying the separated methamphetamine, filtering the separated methamphetamine, and evaporating the solvent to obtain the methamphetamine. Dissolve 120mg of methamphetamine in 120ml of absolute ethanol (spectrum pure), then add 100ml of 1mol / L N-(4 bromobutyl)phthalimide-absolute ethanol solution, and add 1-5ml appropriately Triethylamine helps to dissol...

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Abstract

The invention discloses a preparation method of a methylamphetamine-resistant egg yolk antibody and belongs to the field of medicines for drug rehabilitation. The preparation method of the methylamphetamine-resistant egg yolk antibody comprises the following steps: carrying out immunization on a laying hen by adopting methylamphetamine-bovine serum albumin antigen, collecting eggs laid by the immunized laying hen, extracting and purifying the egg yolk antibodies in the eggs, wherein the obtained egg yolk antibodies are the methylamphetamine-resistant egg yolk antibodies namely. The specific methylamphetamine-resistant egg yolk antibody can firstly neutralize free methylamphetamine in blood of a patient, so that quantity of methylamphetamine entering into the central nervous system of the patient is reduced, and toxicity of the methylamphetamine to nerve cells in the brain is further reduced; meanwhile, the methylamphetamine-resistant egg yolk antibody can be taken as a hard drug molecule receptor blocker, and positive strengthening of the hard drug can be prevented in certain degree, so that psychological desire of the patient is alleviated and probability of relapse of the patient can be reduced.

Description

technical field [0001] The invention relates to the field of drugs for detoxification, in particular to a method for preparing an anti-methamphetamine yolk antibody. Background technique [0002] Methamphetamine is a central stimulant that has toxic effects on animal and human brain neurons. Its half-life is as long as 10-30 hours. Symptoms and severe mental symptoms such as confusion and delirium can lead to death in severe poisoning. Long-term use, short-term repeated use, or one-time large-dose use of methamphetamine can all lead to addiction. [0003] For the prevention and treatment of methamphetamine overdose and relapse, researchers are actively exploring in recent years, but most of the prevention and treatment is limited to the toxic effects of methamphetamine on the central nervous system, for example, targeting the dopamine system. The drugs bupropion, selegiline, and the drugs vigabatrin and baclofen that act on the γ-aminobutyric acid system. [0004] In the p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/44C07K16/02
Inventor 陈琳李超英乐凯茹琴马宝苗田香熊琪
Owner JIANGHAN UNIVERSITY
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