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Photothermal effect tissue treatment optimizing and monitoring method and device

A photothermal effect and tissue technology, applied in applications, diagnostic recording/measurement, medical science, etc., can solve the problems of cumbersome magnetic resonance methods, slow response to temperature changes, and low ultrasonic resolution, and achieve the integration of treatment optimization and monitoring chemical, to avoid the effect of toxic effects

Inactive Publication Date: 2014-07-16
李志芳
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Problems solved by technology

Due to the high penetration depth of ultrasound, it can be used to monitor temperature changes during photothermal therapy, but ultrasound has low resolution and slow response to temperature changes; while magnetic resonance methods have high resolution and high sensitivity, but magnetic resonance methods Resonance methods are bulky and slow

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  • Photothermal effect tissue treatment optimizing and monitoring method and device
  • Photothermal effect tissue treatment optimizing and monitoring method and device
  • Photothermal effect tissue treatment optimizing and monitoring method and device

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Embodiment Construction

[0014] Depend on figure 1 It can be seen that the device of the present invention is composed of a pulsed laser 1 , a continuous laser 2 , an optical fiber assembly 3 , an acoustic signal collection assembly 4 , a computer sample assembly 5 , a sample fixing assembly 6 , a coupling assembly 7 , and a scanning assembly 8 . Among them, the continuous laser 1 is a semiconductor continuous laser (810nm), the pulse laser 2 is a Nd:YAG laser, and its output wavelength is 532nm, the pulse width is 5ns, and the repetition rate is 10Hz. In an optical fiber with a diffuse end, the acoustic signal acquisition component 4 is amplified by a water-immersed focused ultrasonic transducer 4-1 through a signal amplifier 4-2, averaged by an oscilloscope 4-3, and then collected by a computer 5 with a GPIB card through control software . The sample fixing component 6 uses a three-dimensionally adjustable sample stage to fix the position of the sample, and keeps the sample part to be observed in c...

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Abstract

The invention relates to a photothermal effect tissue treatment optimizing and monitoring method and device. Continuous intensive laser and pulse laser are transmitted through a flexible diffusion end multimode fiber which is inserted into tissue in a minimal invasion manner, and the same area of the tissue can be irradiated. The continuous intensive laser mainly produces the photothermal effect to cause tissue temperature to change; the pulse laser mainly produces photoacoustic signals, temperature changes of the tissue being monitored are changed according to the strength of the photoacoustic signals, dosage and irradiation time of the continuous intensity laser are regulated in time as required, and optimized photothermal effect is achieved.

Description

technical field [0001] The invention belongs to the field of photothermal therapy technology and monitoring, and in particular relates to a method and device for optimizing and monitoring laser-induced photothermal therapy. Background technique [0002] Tumor is an important disease affecting human health. The "2012 China Cancer Registration Annual Report" issued by the National Cancer Registration Center pointed out that the national cancer mortality rate was 1.8054 / 100,000, and the number of cancer deaths per year reached 2.7 million. The probability of death due to cancer among Chinese residents is 13%, that is, 1 out of every 7 to 8 people dies from cancer. At present, the methods of photothermal therapy for tumors are mainly coagulation and laser immunotherapy. The former uses high-temperature coagulation of tissues to kill tumors, while the latter uses photothermal effects to kill tumors to release tumor antigens and combine with immune adjuvants to stimulate systemi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61B18/22A61B5/00
Inventor 不公告发明人
Owner 李志芳
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