Optical Sensing Chip
A technology of optical sensing chip and three-dimensional nanostructure, which is applied in the direction of material analysis, measuring device and scientific instrument by optical means, which can solve the problems of increased restriction, high biological toxicity of fluorescent molecules, and long immune response time.
Active Publication Date: 2014-07-16
IND TECH RES INST
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Problems solved by technology
Although the sensitivity is quite good, it cannot be integrated into a point-of-care monitoring system due to the long time required for the immune response
In addition, fluorescent molecules often have high biological toxicity, and the fluorescent molecules that must be removed after measurement also lead to increased limitations
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[0030] The invention relates to an optical detection chip, which can be widely used in the sensing of various small molecules. The so-called small molecules here roughly refer to molecules with a molecular weight below 100kDa, including chemical molecules, drugs, amino acids, peptides, and small charged molecules. For biological samples, the sensor chip measurement mechanism does not need to use the general antibody-antigen immunolabeling reaction.
[0031] The present invention applies the principle of Raman optics. The Raman characteristic spectrum is generated because the molecules and the metal are close to each other, so that the localized surface plasmon resonance (LSPR) generated on the metal surface can be used to concentrate the electric field in a very localized area. Locally, the state of the molecular vibration membrane of the molecule to be measured is changed by local amplification of the electric field, and finally a characteristic fingerprint spectrum with a ch...
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Abstract
The present invention relates to an optical sensing chip, which has various applications and may be used repetitively. The optical sensing chip can qualitatively identify different types of molecules and quantitatively analyze small molecules in minute amounts. Regarding a conventional optical sensing chip, an additional sample of known concentration is required as a reference in signal comparison for quantitative determination. In the disclosure, it is unnecessary to add the additional sample of known concentration, but the optical sensing chip itself provides a fixed optical signal that is not varied along with environmental changes to serve as a reference for quantitative determination. In addition, the optical sensing chip also possesses the ability to concentrate or filter sample in real-time.
Description
technical field [0001] The present invention relates to a sensing chip, and in particular to an optical sensing chip. Background technique [0002] The current biosensors on the market can be mainly classified into optical sensing chips that rely on chemical reaction (or color reaction) mechanism or rely on immunofluorescence calibration mechanism. [0003] In sensors with general chemical reaction mechanisms, an electrochemically active molecule or a color-changing molecule is always required as a reporter, but the added reporter is difficult to remove after the reaction, which will contaminate the original sample system. In addition, a certain proportion of the active reaction surface will be consumed for each reaction, so it is difficult to perform multiple and continuous detection. [0004] In the immunofluorescence calibration mechanism, in addition to the limitations of the immune reaction, fluorescent molecules need to be added. After the immune reaction is carried ...
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IPC IPC(8): G01N21/65
CPCG01N21/658B82Y15/00Y10S977/92
Inventor 张家荣林靖渊
Owner IND TECH RES INST