Traditional Chinese medicine composition for treating gout

A composition and technology of traditional Chinese medicine, applied in the field of medicine, can solve problems such as bone marrow toxicity, liver and kidney damage, and large toxicity, and achieve the effects of accurate curative effect, lower blood uric acid content, and short treatment cycle

Active Publication Date: 2014-07-23
周晓明
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Colchicine can inhibit the aggregation of white blood cells in inflamed joints and inhibit cell mitosis. It has special effects on stopping inflammation and relieving pain, so it is often used as the first choice for gout attacks. , kidney damage, and obvious bone marrow toxicity
Corticosteroids are generally used when the above two types of drugs are ineffective or contraindicated, and various adverse reactions may occur and rebound after drug withdrawal
At present, the traditional Chinese medical treatment means for gout are often some ethnic folk ointments, mostly based on expelling wind and cold, removing numbness and relieving pain, and the effect is slow, and the curative effect is not obvious. illness

Method used

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  • Traditional Chinese medicine composition for treating gout
  • Traditional Chinese medicine composition for treating gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Take selected Chinese medicine raw materials with the following weights, screen, wash, dry, and pulverize for later use:

[0046] Salvia 12g, Polygonum cuspidatum 12g, Fangfeng 8g, Gentiana 12g, Scutellaria baicalensis 12g, Corydalis 8g, Guizhi 8g, Lycium barbarum 12g, Duhuo 6g, Poria cocos 8g, Licorice 12g

[0047] Add 6-10 times of distilled water to the top and decoct twice, each time for 1 hour. After filtering, combine the two decoctions, let it stand still, take the supernatant and concentrate to obtain a concentrated solution, add the mass percentage while stirring Wash with 95% ethanol until the mass percentage of ethanol reaches 50%, stir well and let it stand for 48 hours, take the supernatant, recover ethanol, continue to concentrate to a thick paste, vacuum dry below 80°C, and pulverize. Granulate with about 85% ethanol to obtain granule preparation.

[0048] Pharmacodynamic test research:

Embodiment 1）

[0049] Effect of medicine of the present invention (embodiment 1) on mouse ear swelling caused by croton oil

[0050] Materials and Methods:

[0051] 50 healthy adult mice were selected from the Kunming mice bred by the Experimental Center of Zhejiang Province, with a body weight of 18-22g. medicinal materials / kg), a high-dose group of the drug of the present invention (16g raw medicinal materials / kg), a control group (normal saline) and a positive control group (indomethacin). 10 in each group. Oral administration once a day for 3 consecutive days. One hour after the last administration, 50 μl of croton oil was applied to the front and back sides of the right ear. After 2 hours, the mice were sacrificed by devertebral dissection, and the two ears were cut off along the baseline of the auricle. weight, the difference between the weight of the left and rear ear piece was calculated as the degree of swelling, and the average of each group was compared with the control gro...

Embodiment 2

[0078] Take selected Chinese medicine raw materials with the following weights, screen, wash, dry, and pulverize for later use:

[0079] Codonopsis 12g, Salvia 9g, Polygonum cuspidatum 9g, Fangfeng 9g, Gentiana 9g, Scutellaria baicalensis 12g, Corydalis 6g, Guizhi 6g, Lycium barbarum 6.75g, Cnidium 6g, Poria cocos 6g, licorice 6g.

[0080] Add 6-10 times of distilled water to the top and decoct twice, each time for 1 hour. After filtering, combine the two decoctions, let it stand still, take the supernatant and concentrate to obtain a concentrated solution, add the mass percentage while stirring Wash with 95% ethanol until the mass percentage of ethanol reaches 50%, stir well and let it stand for 48 hours, take the supernatant, recover ethanol, continue to concentrate to a thick paste, vacuum dry below 80°C, and pulverize. Granulate with about 85% ethanol to obtain granule preparation.

[0081] Pharmacodynamic test research:

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Abstract

The invention discloses a traditional Chinese medicine composition for treating gout. The traditional Chinese medicine composition for treating gout is prepared from the following raw materials in parts by weight: 8-12 parts of salvia miltiorrhiza, 6.75-12 parts of polygonum cuspidatum, 6.75-9 parts of radices sileris, 6.75-12 parts of gentiana macrophylla, 9-12 parts of scutellaria baicalensis, 4.5-8 parts of rhizoma corydalis, 4.5-8 parts of cassia twig and 6.75-12 parts of medlar. The traditional Chinese medicine composition for treating gout, which is provided by the invention, has remarkable anti-inflammatory and abirritation effects, is capable of remarkably lowering the content of blood uric acid, good in treatment effect on gout, short in treatment period, low in cost, and free from obvious toxic and side effects and adverse reactions, and provides a new choice for clinic.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine composition for treating gout. Background technique [0002] Gout is a disease caused by the accumulation of uric acid due to purine metabolism disorders. It is a type of arthritis, also known as metabolic arthritis. The metabolism of purine in the human body is disturbed, producing too much uric acid, or renal excretion dysfunction, resulting in hyperuricemia. Uric acid deposits in the joints, cartilage and kidneys in the form of sodium salt along with the blood circulation, causing tissue foreign body An inflammatory response that produces severe pain. Gout damage to the joints is common in the small joints of the hands and feet. The general site of attack is the thumb joint, ankle joint, knee joint, etc. In the early stage of gout, the attack is more common in the joints of the lower limbs. In long-term gout patients, the attack occurs ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61P19/06
Inventor 周晓明
Owner 周晓明
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