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In-vivo implanted composite material with X-ray developing performance and preparation method of in-vivo implanted composite material

A composite material and X-ray technology, applied in the field of implanted composite materials in vivo, can solve the problems of affecting the mechanical properties of materials, inability to intuitively understand the implantation situation, and failure to improve the X-ray imaging performance, etc., and achieve good mechanical properties and ease of use. Processability

Active Publication Date: 2014-07-30
天津和杰医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this kind of polymer material does not develop under X-rays, and the implantation status cannot be intuitively understood through X-rays after surgical implantation.
[0003] Chinese patent CN200810040800.0 discloses a nano-modified high-density polyethylene composite material and a preparation method thereof, and relates to a sodium stearate-coated modified nano-barium sulfate-modified high-density polyethylene composite material and a preparation method thereof. The amount of barium sulfate in the medium accounts for 1 to 5% by weight of high-density polyethylene, and the content of barium sulfate is low, which only plays a role in improving the mechanical properties, but fails to improve the X-ray imaging performance
Chinese patent CN201010215660.3 discloses a compound for IUD, which is composed of low-density polyethylene and barium sulfate. Although the effect of X-ray imaging can be achieved, the barium sulfate has not undergone surface treatment, and the two substances are directly blended The granulation process makes barium sulfate agglomerated as a dispersed phase, which affects the mechanical properties of the material

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) 2kg average particle diameter is dispersed in 2 liters of water under the condition of high-speed stirring with the barium sulfate particle of 5 μm, stirring rate is controlled at 90 ± 10rpm, and the stirring time is 40 ± 10min to obtain uniformly dispersed barium sulfate particle suspension; Add 400ml of myristic acid ethanol solution with a weight concentration of 2.0wt% dropwise into the barium sulfate particle suspension, adjust the stirring rate to 90±10rpm, control the temperature at 50±5°C, adjust the pH to about 6.0, and react for 50min Finally, stop, and then obtain surface-modified barium sulfate particles through cooling, filtration, vacuum drying, and the average particle diameter of the surface-modified barium sulfate particles is 5 μm;

[0019] (2) 1.99 kg of low-density polyethylene with a relative density of 0.91 to 0.92, 2 kg of surface-modified barium sulfate particles, pentaerythritol [3-(3',5'di-tert-butyl-4'-hydroxypropyl) propane Acid] ester 10...

Embodiment 2

[0025] Preparation of composite materials for intrauterine devices.

[0026] (1) under high-speed stirring condition, the barium sulfate particle that 6kg mean particle diameter is 20 μ m is dispersed in 6 liters of water, and stirring speed is controlled at 100 ± 10rpm, and the stirring time is 50 ± 10min to obtain uniformly dispersed barium sulfate suspension; Add 1.2 liters of ethanol solution of myristic acid with a weight concentration of 2.0wt% dropwise into the barium sulfate particle suspension, adjust the stirring rate to 100±10rpm, control the temperature at 50±5°C, adjust the pH to about 6.0, and react for 60min Stop, then obtain surface-modified barium sulfate particles through cooling, filtration, vacuum drying, the average particle diameter of the surface-modified barium sulfate particles is 20 μm;

[0027] (2) 3.97 kg of low-density polyethylene with a relative density of 0.91 to 0.92, 6 kg of surface-modified barium sulfate particles, pentaerythritol [3-(3',5'd...

Embodiment 3

[0032] Preparation of composite materials for venous catheters.

[0033] (1) 4kg mean particle diameter is dispersed in 4 liters of water by the barium sulfate particle of 600nm under high-speed stirring condition, and stirring rate is controlled at 100 ± 10rpm, and stirring time is that 50 ± 10min obtains the evenly dispersed barium sulfate particle suspension solution; Add 800ml of stearic acid ethanol solution with a weight concentration of 2.0wt% dropwise into the barium sulfate particle suspension, adjust the stirring rate to 100±10rpm, control the temperature at 40±5°C, adjust the pH to about 7.0, and stop the reaction after 50min , and then obtain surface-modified barium sulfate particles through cooling, filtering, and vacuum drying, and the average particle diameter of the surface-modified barium sulfate particles is 600nm;

[0034] (2) 3.97 kg of high-density polyethylene with a relative density of 0.94 to 0.96, 4 kg of surface-modified barium sulfate particles, pent...

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Abstract

The invention provides an in-vivo implanted composite material with X-ray developing performance. The composite material is prepared from the following components in percentage by weight: 5-60 percent of barium sulfate particles, 0-1 percent of an antioxidant, and the balance of a matrix material. The composite material has the advantages of clear X-ray development, excellent mechanical performance, good biocompatibility, simple preparation process and the like, and can be used for preparing a human body bone tissue repairing material, an artificial joint cartilage tissue repairing material, an intrauterine device, venous cannula, a urea catheter, a blood transfusion tube, a catheter and the like.

Description

technical field [0001] The invention relates to a composite material implanted in the body, in particular to a composite material implanted in the body with X-ray developing performance. Background technique [0002] Low-density polyethylene materials, high-density polyethylene materials, and polypropylene materials are commonly used implantable polymer materials, which can be used to prepare human bone tissue repair materials, artificial articular cartilage tissue repair materials, intrauterine devices, intravenous catheters, catheters, etc. Urinary catheters, blood vessels and catheters have played a very important role in the development of modern medical technology. However, such polymer materials do not develop under X-rays, and the implantation status cannot be intuitively understood through X-rays after surgical implantation. [0003] Chinese patent CN200810040800.0 discloses a nano-modified high-density polyethylene composite material and a preparation method thereo...

Claims

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Application Information

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IPC IPC(8): A61L27/44A61L29/12A61L29/18A61L31/12A61L31/18
Inventor 周彦清朱孔营于秀艳谢青松陈允敬
Owner 天津和杰医疗器械有限公司
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