A method of preparing a collagen/silica gel membrane double-layer stent

Abstract

The invention relates to a method for preparing a collagen protein / silica membrane double-layer stent. According to the invention, a collagen sponge with a porous network structure is prepared through different crosslinking methods, and a layer of silica membrane with different thicknesses is coated on the collagen sponge again, then the collagen protein / silica membrane double-layer stent is prepared. The collagen protein / silica membrane double-layer stent obtained in the invention has a good effect in an application of being used as an artificial skin stent material, and two layers of the material have different functions, namely the outer layer of the silica membrane has higher mechanical strength to be capable of supporting and protecting a wound, and a good gas-liquid permeability performance to be capable of effectively preventing fluid loss, and a moderate density performance to be capable of preventing bacterial infections and providing a moister environment for wound repair; the inner layer of the collagen sponge can effectively promote cell proliferation and differentiation, delay wound contraction and accelerate wound healing.

Description

technical field

[0001] The invention relates to a method for preparing a collagen / silica gel membrane double-layer support. The double-layer scaffold prepared by the invention is applied to the fields of tissue wound repair materials, tissue engineering skin scaffold materials, artificial skin and the like. Background technique

[0002] In recent years, with the rapid development of cell biology, molecular biology and biomaterials, tissue engineering has also made great progress, and the development of skin tissue engineering is particularly noticeable. During the process, the scaffold material on which the seed cells depend has been one of the hotspots of research. Scaffold materials for skin tissue engineering play an important role in the construction of artificial skin and are one of the three elements of tissue engineering by providing a space environment for cells to adhere, proliferate, and migrate. Collagen (Col), as one of the main components of the extracellular ...

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