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A method of preparing a collagen/silica gel membrane double-layer stent

A technology of collagen and collagen sponge, which is applied in the field of preparation of collagen/silicone film double-layer scaffolds, can solve the problems of poor mechanical properties, poor degradation resistance, slow wound healing, etc., and achieves controllable size and thickness and strong adhesion Sexuality, effect of promoting rapid healing

Active Publication Date: 2015-09-16
无锡贝迪生物工程股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The composite scaffold prepared by the present invention overcomes the problems of poor mechanical properties, poor degradation resistance, and slow wound healing of current skin scaffold materials in clinical applications

Method used

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  • A method of preparing a collagen/silica gel membrane double-layer stent
  • A method of preparing a collagen/silica gel membrane double-layer stent
  • A method of preparing a collagen/silica gel membrane double-layer stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A 0.5% collagen aqueous solution was freeze-dried into a collagen sponge with a size of 50×50×5 mm, and the collagen sponge was cross-linked in a vacuum oven at 80° C. for 48 hours using a heat-crosslinking system. After cross-linking, a layer of silica gel film was coated on the collagen sponge with a thickness of 0.5 mm, and cured at room temperature for 24 hours. After curing, the collagen / silica gel membrane double-layer scaffold is obtained. The properties of the prepared double-layer stents are shown in Table 1.

Embodiment 2

[0034]A 1% collagen aqueous solution was freeze-dried into a collagen sponge with a size of 50×50×4 mm, and a thermal crosslinking system was used to crosslink the collagen sponge in a vacuum oven at 90° C. for 60 hours. After cross-linking, a layer of silica gel film was coated on the collagen sponge with a thickness of 0.4 mm, and cured at room temperature for 24 hours. After curing, the collagen / silica gel membrane double-layer scaffold is obtained. The properties of the prepared double-layer stents are shown in Table 1.

Embodiment 3

[0036] A 1.5% collagen aqueous solution was freeze-dried into a collagen sponge with a size of 50×50×3.5 mm, and the collagen sponge was cross-linked in a vacuum oven at 100° C. for 72 hours by using a heat-crosslinking system. After cross-linking, a layer of silica gel film was coated on the collagen sponge with a thickness of 0.35 mm, and cured at room temperature for 24 hours. After curing, the collagen / silica gel membrane double-layer scaffold is obtained. The properties of the prepared double-layer stents are shown in Table 1.

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Abstract

The invention relates to a method for preparing a collagen protein / silica membrane double-layer stent. According to the invention, a collagen sponge with a porous network structure is prepared through different crosslinking methods, and a layer of silica membrane with different thicknesses is coated on the collagen sponge again, then the collagen protein / silica membrane double-layer stent is prepared. The collagen protein / silica membrane double-layer stent obtained in the invention has a good effect in an application of being used as an artificial skin stent material, and two layers of the material have different functions, namely the outer layer of the silica membrane has higher mechanical strength to be capable of supporting and protecting a wound, and a good gas-liquid permeability performance to be capable of effectively preventing fluid loss, and a moderate density performance to be capable of preventing bacterial infections and providing a moister environment for wound repair; the inner layer of the collagen sponge can effectively promote cell proliferation and differentiation, delay wound contraction and accelerate wound healing.

Description

technical field [0001] The invention relates to a method for preparing a collagen / silica gel membrane double-layer support. The double-layer scaffold prepared by the invention is applied to the fields of tissue wound repair materials, tissue engineering skin scaffold materials, artificial skin and the like. Background technique [0002] In recent years, with the rapid development of cell biology, molecular biology and biomaterials, tissue engineering has also made great progress, and the development of skin tissue engineering is particularly noticeable. During the process, the scaffold material on which the seed cells depend has been one of the hotspots of research. Scaffold materials for skin tissue engineering play an important role in the construction of artificial skin and are one of the three elements of tissue engineering by providing a space environment for cells to adhere, proliferate, and migrate. Collagen (Col), as one of the main components of the extracellular ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/40A61L27/24A61L27/02A61L27/60A61L15/32A61L15/18A61L15/42C08J9/36C08J9/28C08J3/24
Inventor 任伟业陈敬华陆金婷魏玲
Owner 无锡贝迪生物工程股份有限公司
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