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Microneedle of short-time dissolution type

A microneedle and aqueous solution technology, which is applied in the direction of microneedles, needles, medical preparations of non-active ingredients, etc., can solve the problems that the active ingredients cannot fully enter the body, the adhesion parts are broken or peeled off, etc., so as to shorten the absorption time and reduce the The effect that burden, usage is simple

Active Publication Date: 2014-09-24
COSMED PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if the active ingredient is attached to the tip of the microneedle using the conventional method, the adhered part may be broken or peeled off when piercing the skin, resulting in the inability of the active ingredient to fully enter the body.

Method used

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  • Microneedle of short-time dissolution type
  • Microneedle of short-time dissolution type
  • Microneedle of short-time dissolution type

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～24 and comparative example 1～13

[0045] (Manufacturing method of microneedle array)

[0046] The microneedle arrays described in Examples 1-24 and Comparative Examples 1-13 were manufactured using the materials in Table 1 and Table 2. In addition, in Examples 11, 12, 17, and 19, active ingredients described later were added.

[0047] Details of the water-soluble polymers shown in Table 1 and Table 2 are as follows.

[0048] Hyaluronic acid is produced by KIKKOMAN BIOCHEMIFA Co., Ltd., and its molecular weight is 800,000 (trade name: FCH-80LE). Dextran is purchased from Japan BULK Pharmaceutical Co., Ltd. (trade name: Dextran 70). Co., Ltd. (trade name: Kollidon12PF), collagen is produced by Nippi Co., Ltd. (trade name: RiasShark), gelatin is produced by Nippi Co., Ltd. (trade name: Nippi Highgrade gelatin A P A T), and proteoglycan is produced by Biomatec Japan Co., Ltd. Produced by the company (trade name: Natural Proteoglycan).

[0049] Sugars in Table 1 and Table 2, such as monosaccharides, disaccharide...

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Abstract

Provided is a microneedle material which dissolves in a short time and can be rapidly absorbed. Thus, the time required for microneedle application is shortened. As the microneedle material, use is made of a mixture of one or more water-soluble polymers and one or a plurality of saccharides selected from monosaccharides and disaccharides. Suitable for use as the water-soluble polymer(s) is a synthetic polymer, a protein, a polysaccharide, or a mixture of these. Suitable for use as the saccharides is any of glucose, fructose, sucrose, and lactose or a mixture of these.

Description

technical field [0001] The present invention is a description of a rapidly dissolving microneedle material manufactured to impart a cosmetic effect and / or a functional effect to the surface layer of the skin and / or the stratum corneum of the skin. Background technique [0002] Usually, the ways for active ingredients to enter the human body mainly include oral and transdermal methods. A typical transdermal means is injection. However, the injection requires the operation of professional technicians such as doctors and nurses, and the injection is painful, and AIDS and hepatitis B may be transmitted. So, injections are not a popular method for many people. In recent years, painless transdermal technology using microneedles has attracted attention (Patent Document 1, Non-Patent Document 1). [0003] The active ingredients referred to here are substances that improve the human body after administration, such as drugs or cosmetics. [0004] The stratum corneum is the main ba...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00A61L31/00
CPCA61L31/041A61K47/26A61M2037/0061A61L31/148A61K9/0021A61M37/0015A61M2037/0046
Inventor 权英淑神山文男
Owner COSMED PHARMA
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