Production method for nadroparin calcium

Abstract

The invention discloses a production method for nadroparin calcium. Accoding to the production method, heparin sodium is adopted as raw material and subjected to degradation, deoxidation, ethanol precipitation, ion exchange resin calcium conversion, oxidation, filtration, precipitation and dehydration to obtain nadroparin calcium; the one-pot boiling technology is realized through oxidation, sterile filtration, precipitation and dehydration and the simplified operation is realized; compared with the disclosed methods, steps adopted in the heparin sodium preparation technology are fewer, the operation is simpler and more convenient, the calcium conversion is more complete and the yield is higher.

Description

technical field

[0001] The invention relates to the field of biomedicine, in particular to a method for producing nadroparin calcium. Background technique

[0002] Heparin Sodium is a mucopolysaccharide sulfate anticoagulant. Heparin sodium is the sodium salt of aminodextran sulfate extracted from the intestinal mucosa of pigs or cattle, and belongs to mucopolysaccharides. It has anticoagulant effect both in vivo and in vitro, and is currently the mainstream anticoagulant drug. However, the bioavailability of unfractionated heparin is low and the side effects are large. Later, it was discovered that the sodium salt of aminodextran sulfate fragment obtained by cleavage of heparin sodium has an average molecular weight of 4000-6000 Daltons, which is called low molecular weight heparin sodium. Low molecular weight heparin sodium injection, like heparin sodium injection, is an antithrombin Ⅲ (AT Ⅲ) dependent thrombin inhibitor. However, compared with heparin sodium injection,...

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