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Application of cornflower-3-oxo-glucoside in medicines for treating obesity and related diseases

A technology of glucoside and cornflower, which is applied in the field of health care products, can solve the problems that have not yet been achieved, and achieve the effects of increasing energy metabolism, enhancing insulin sensitivity, and improving insulin resistance

Active Publication Date: 2014-10-08
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are currently no studies investigating the use of cyanidin-3-oxo-glucoside for the treatment of obesity or obesity-related disorders and for improving energy metabolism or promoting fever

Method used

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  • Application of cornflower-3-oxo-glucoside in medicines for treating obesity and related diseases
  • Application of cornflower-3-oxo-glucoside in medicines for treating obesity and related diseases
  • Application of cornflower-3-oxo-glucoside in medicines for treating obesity and related diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 Research on the anti-obesity effect of cyanidin-3-oxo-glucoside

[0041] In order to verify the anti-obesity effect of C3G (cyanidin-3-oxy-glucoside), we selected the db / db mouse model: 4-week-old db / db male mice were randomly divided into control groups (control group, 10 rats) and cyanidin-3-oxo-glucoside group (C3G group, 10 rats).

[0042] Diet: normal diet (feeding low-fat feed) in the control group and C3G group;

[0043] Drinking water: control group, free to drink ordinary water.

[0044] In the C3G group, drink water containing 1 mg / ml cyanidin-3-oxy-glucoside (the average daily water intake of db / db mice in the C3G group is detected on the next day, and the average daily water consumption of the mice is calculated to be equivalent to eating 200 mg / kg body weight) to give drug; continuous administration.

[0045] Body weights were recorded each week of dosing. After 15 weeks of continuous administration, the mice were sacrificed by enucleating the...

Embodiment 2

[0049] Example 2 Research on the effect of cyanidin-3-oxo-glucoside on insulin resistance

[0050] Many research results show that obesity is often accompanied by severe insulin resistance. For this reason, the present invention took the mice administered in the 12th week in Example 1 and carried out the following experiments:

[0051] 1. Intraperitoneal glucose tolerance test (IPGTT)

[0052] The db / db mice after 12 weeks of administration in Example 1 and the db / db mice of the control group were fasted overnight, and after weighing, they were intraperitoneally injected with glucose, and the injection amount per kg body weight was 1.0g. After the injection, Blood glucose levels were measured at 0 min, 30 min, 60 min, 90 min and 120 min with a blood glucose meter.

[0053] The result is as image 3 as shown, image 3 It is the effect of cyanidin-3-oxo-glucoside on the glucose tolerance of db / db mice.

[0054] Depend on image 3 It can be seen that the fasting blood glucos...

Embodiment 3

[0060] Example 3 Research on the effect of cyanidin-3-oxo-glucoside on energy consumption

[0061] Get the db / db mice after the 9th week of administration in Example 1 and the db / db mice of the control group, adopt the animal metabolism measurement and analysis system (LabMaster) to detect its oxygen consumption, and the db / db mice Place them at 25°C and 4°C respectively, and measure body temperature.

[0062] The result is as Figure 6-7 as shown, Figure 6 The effect of cyanidin-3-oxo-glucoside on the oxygen consumption of db / db mice; Figure 7 It is the effect of cyanidin-3-oxo-glucoside on body temperature of db / db mice.

[0063] Depend on Figure 6 It can be seen that the daytime oxygen consumption of the mice in the control group was 1733.43±61.96ml / h.kg, and the nighttime oxygen consumption was 2001.92±59.63ml / h.kg; the daytime oxygen consumption of the mice in the C3G group was 2065.30±85.73ml / h. kg, the oxygen consumption at night was 2143.65±109.66ml / h.kg, and t...

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Abstract

The invention provides an application and using method of cornflower-3-oxo-glucoside in medicines for treating obesity and obesity-related diseases and improving energy metabolism or promoting pyrexia. Meanwhile, the invention also provides a medicine for treating obesity and obesity-related diseases and improving energy metabolism or promoting pyrexia, wherein the medicine comprises the cornflower-3-oxo-glucoside. The test proves that the cornflower-3-oxo-glucoside can effectively inhibit obesity of db / db model mice and improve insulin resistance of the db / db model mice. The adaptability of an organism on cold stimulation is improved by increasing the energy metabolism level of the organism, improving the glucose tolerance of the organism, enhancing insulin sensitivity of tissues and activating heat production of the organism, and a novel way is developed for treatment of the obesity and related diseases.

Description

technical field [0001] The invention belongs to the field of health care products, and in particular relates to the application of a natural extract, in particular to a plant polyphenol—Cyanidin-3-O-glucoside chloride (Cyanidin-3-O-glucoside chloride) for treating obesity applications in obesity or obesity-related diseases and drugs that improve energy metabolism or promote fever. Background technique [0002] The occurrence of obesity is the result of the imbalance of energy metabolism in the body, that is, when the body's energy intake exceeds energy consumption, almost all of the remaining energy is converted into triglycerides and stored in white adipose tissue (WAT) throughout the body. At present, with the improvement of people's living standards and changes in dietary structure, excessive food intake and reduction in physical activity and exercise have led to imbalances in energy metabolism in people's bodies, and obesity has become an unavoidable problem for humans. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P3/04A61P3/10A61P3/00A61P5/50
Inventor 战吉宬游义琳黄卫东孙翔宇
Owner CHINA AGRI UNIV
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