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A kind of method of extracting sennoside A in rhubarb tangut

A technology of sennoside and rhubarb, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc.

Inactive Publication Date: 2016-04-27
XIHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In terms of the detection of rhubarb active ingredients, most of them focus on the content determination of free anthraquinone compounds in 5, or only the content determination of sennoside A. There is no research on the extraction process in all domestic research

Method used

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  • A kind of method of extracting sennoside A in rhubarb tangut
  • A kind of method of extracting sennoside A in rhubarb tangut
  • A kind of method of extracting sennoside A in rhubarb tangut

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Example 1NaHCO 3 Effect of Solution Concentration on Extraction Rate of Sennoside A

[0023] Weigh 6 parts of Tangut rhubarb powder, each 0.25g, add 50mL of NaHCO with mass percent concentration of 0.1%, 0.15%, 0.2%, 0.25%, 0.3%, and 0.35% respectively 3 solution, weighed, recorded the weight, then ultrasonicated for 40min under the same conditions, allowed to cool, and each NaHCO 3 The solution is made up to weight. Filtration, sample injection, record the chromatogram, and calculate the extraction rate of sennoside A as figure 1 ,From figure 1 It can be seen that with NaHCO 3 With the increase of solution concentration, the obtained sennoside A also increases, when NaHCO 3 When the concentration of the solution reaches 0.15%, the extraction rate is the highest, and then with NaHCO 3 As the concentration of the solution continued to increase, the extraction rate decreased gradually.

Embodiment 2

[0024] Example 2NaHCO 3 The Effect of Solution Volume on the Extraction Rate of Sennoside A

[0025] Take by weighing 6 parts of Tangut rhubarb powder, every part of 0.25g, put into the NaHCO that is equipped with mass percentage concentration and be 0.1%. 3 Put the solutions in 30mL, 40mL, 50mL, 60mL, 70mL, 80mL conical flasks, weigh them, sonicate for 40min under the same conditions, let cool, and use each NaHCO 3 The solution is made up to weight. Filtration, sample injection, record the chromatogram, and calculate the extraction rate of sennoside A as figure 2 ,Depend on figure 2 It can be seen that with NaHCO 3 As the volume of the solution increases, the obtained sennoside A also increases. When NaHCO 3 The extraction rate was the highest when the solution volume reached 40mL, and then with NaHCO 3 As the volume of the solution continued to increase, the extraction rate decreased gradually.

Embodiment 3

[0026] The influence of embodiment 3 ultrasonic extraction time on sennoside A extraction rate

[0027] Weigh 6 parts of Tangut rhubarb powder, each 0.25g, put into 50mL of NaHCO with a mass percentage concentration of 0.1%. 3 Put the solution in an Erlenmeyer flask, weigh it, and ultrasonicate it for 20, 30, 40, 50, 60, and 70 minutes under the same conditions, let it cool, and use each NaHCO 3 The solution is made up to weight. Filtration, sample injection, record the chromatogram, and calculate the extraction rate of sennoside A as image 3 ,Depend on image 3 It can be seen that as the ultrasonic extraction time increases, the obtained sennoside A also increases, and the extraction rate is the highest when the ultrasonic extraction time reaches 40 min, and then gradually decreases as the ultrasonic extraction time continues to increase.

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Abstract

The invention discloses a method extracting sennoside A in rheum tanguticum maxim ex balf. The method comprises the following steps: weighing 0.25 g of rheum tanguticum maxim ex balf powder; dissolving the powder in 40.8 mL of NaHCO3 solution of which the mass percentage concentration is 0.15%; conducting supersonic extraction for 40.5 min; filtering. The method optimizes the extracting method of the sennoside A in the rheum tanguticum maxim ex balf for the first time, and is stable; the extracting rate of the sennoside A is high; the method lays foundation for purification and industrialized development of the sennoside A in the rheum tanguticum maxim ex balf.

Description

technical field [0001] The invention relates to the field of organic chemistry, in particular to a method for extracting sennoside A from rhubarb tangut. Background technique [0002] Rhubarb is a commonly used clinical traditional Chinese medicine, which has the following three sources: it is the dry root and rhizome of Rheumpalmatum L., Rheumtanguticum Maxim.exBalf. or RheumofficinaleBaill. Accumulation, clearing heat and purging fire, cooling blood and detoxification, expelling blood stasis and stimulating menstruation. Rhubarb mainly includes free and combined anthraquinones, dianthrones, catechins and gallic acid, and its purging components are anthraquinones, and sennoside A (sennoside A) has the strongest purging effect. In terms of the detection of rhubarb active ingredients, most of them focus on the content determination of free anthraquinone compounds in 5, or only the content determination of sennoside A. There is no research on the extraction process in all dom...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H15/244C07H1/08
Inventor 李玉锋陈凌李桢刘振东张良赖朋汪静心谢士娟
Owner XIHUA UNIV
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