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Medicine composition for treating haemorrhoids and preparation method thereof

A technology of composition and medicine, applied in the field of pharmaceutical composition

Inactive Publication Date: 2014-11-19
LIAOCHENG PEOPLES HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the constraints of traditional pharmaceutical technology, pharmaceutical excipients and other factors, the research on the dosage forms of traditional Chinese medicine preparations is limited to a certain extent.

Method used

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  • Medicine composition for treating haemorrhoids and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1: the preparation of common granule

[0029] Prescription: 420g fried Sophora japonica, 480g arborvitae leaves, 240g citrus aurantii, 240g nepeta, 300g silkworm, 240g cicada slough, 360g turmeric, 240g rhubarb, 240g pearl ginseng, 480g sage vine.

[0030] Preparation process: take Sophora japonica, orientalis leaves, pearl ginseng, sage rattan and turmeric, add 12 times the amount of 50% ethanol to extract twice, each time for 1.0 hours, combine the alcohol extracts to recover ethanol under reduced pressure; Nepeta add water 12 Double the amount, after soaking for 3 hours, reflux extraction for 8 hours to extract the volatile oil, to obtain 2.5ml of volatile oil, the volatile oil was clathrated with β-cyclodextrin to obtain β-cyclodextrin inclusion powder, that is, the ratio of volatile oil to β-cyclodextrin was 1:10, add 3 times the amount of 30% ethanol, grind in a colloid mill for 60 minutes, separate, dry to obtain β-cyclodextrin inclusion powder, and ...

Embodiment 2

[0031] Embodiment 2: the preparation of common granule

[0032] Prescription: 500g fried Sophora japonica, 500g arborvitae leaves, 250g citrus aurantii, 250g nepeta, 250g silkworm, 250g cicada slough, 500g turmeric, 250g rhubarb, 250g pearl ginseng, 750g sage rattan.

[0033] Preparation process: take Sophora japonica, orientalis leaves, pearl ginseng, sage rattan and turmeric, add 8 times the amount of 70% ethanol to extract twice, each time for 1.0 hours, combine the alcohol extracts to recover ethanol under reduced pressure; Nepeta add water 15 Double the amount, after soaking for 3 hours, reflux extraction for 8 hours to extract the volatile oil, to obtain 2.5ml of volatile oil, the volatile oil was clathrated with β-cyclodextrin to obtain β-cyclodextrin inclusion powder, that is, the ratio of volatile oil to β-cyclodextrin was 1:10, add 3 times the amount of 30% ethanol, grind in a colloid mill for 60 minutes, separate, dry to obtain β-cyclodextrin inclusion powder, and...

Embodiment 3

[0034] Embodiment 3: Preparation of enteric-coated capsules

[0035] Prescription: 1000g fried Sophora japonica, 1000g arborvitae leaves, 500g citrus aurantii, 500g Nepeta, 500g silkworm, 500g cicada slough, 750g turmeric, 500g rhubarb, 500g pearl ginseng, 1250g Daxue vine.

[0036] Preparation process: take Sophora japonica, orientalis leaves, pearl ginseng, sage rattan and turmeric, add 12 times the amount of 70% ethanol to extract twice, each time for 1.0 hours, combine the alcohol extracts to recover ethanol under reduced pressure; Nepeta add water 12 Double the amount, after soaking for 3 hours, reflux extraction for 8 hours to extract the volatile oil to get 1.5ml, the volatile oil is clathrated with β-cyclodextrin to obtain β-cyclodextrin inclusion powder, that is, the ratio of volatile oil to β-cyclodextrin is 1: 6. Add 3 times the amount of 30% ethanol, grind the colloid mill for 60 minutes, separate, and dry to obtain β-cyclodextrin inclusion powder, which is ready...

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Abstract

The invention relates to a medicine composition for treating haemorrhoids and a preparation method thereof. The medicine composition is characterized by consisting of following medicines, by weight: 10-30 parts of fried sophora flower buds, 10-40 parts of platycladus orientalis leaves, 5-20 parts of fructus aurantii, 5-20 parts of herba schizonepetae, 5-25 parts of bombyx batryticatus, 5-20 parts of cicada slough, 10-30 parts of radix curcuma, 5-20 parts of rhubarb, 5-20 parts of rhizome of Largeleaf Japanese ginseng and 15-40 parts of sargentodoxa cuneata. The medicine composition, after being researched for many years, is significant in clinical treatment effects, is more than 46% in curative rate and more than 96% in total effective rate and is good in curative effect, high in curative rate and free of side effects. An enteric preparation of the medicine composition can allows effective ingredients to be avoided from being damaged by internal or external environments such as strong acid in stomach, light, heat and the like. Stability of the medicine composition is improved. Active ingredients are ensured to be completely released in intestinal tracts so that the curative effect of the medicine composition is fully achieved.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating hemorrhoids and a preparation method thereof. Background technique [0002] Hemorrhoids are a common disease located in the anus, accounting for about 87.25% of anorectal diseases. It can occur at any age, but the incidence rate increases with age. Known as "ten men and nine hemorrhoids" and "ten women and ten hemorrhoids", they usually recur and are not easy to cure. There are many inducing factors of hemorrhoids, among which constipation, long-term drinking, eating a large amount of irritating food and sitting for a long time are the main inducing factors. Western medicine mainly has two theories about the cause of hemorrhoids. One is the theory of varicose veins, which believes that hemorrhoids are venous masses formed by the congestion, expansion and buckling of the venous plexus under the mucous membrane of the lower rectum and under...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/16A61K9/48A61P9/14
Inventor 孙四海王晓莉刘芳邵洪锦李瑞芳靳维荣
Owner LIAOCHENG PEOPLES HOSPITAL
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