Compound traditional Chinese medicinal composition for treating venous thrombosis and chemotherapeutic phlebitis, as well as preparation and application of composition

A technique for chemotherapy-induced phlebitis and venous thrombosis, which is applied in the field of medicine to achieve the effects of strong anti-platelet aggregation, increased content, good thrombolysis and anti-inflammatory effects

Inactive Publication Date: 2014-11-19
FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is also the main reason why a powerful and effective thrombolytic traditional Chinese medicine has not yet been developed in China.

Method used

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  • Compound traditional Chinese medicinal composition for treating venous thrombosis and chemotherapeutic phlebitis, as well as preparation and application of composition
  • Compound traditional Chinese medicinal composition for treating venous thrombosis and chemotherapeutic phlebitis, as well as preparation and application of composition
  • Compound traditional Chinese medicinal composition for treating venous thrombosis and chemotherapeutic phlebitis, as well as preparation and application of composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1 The determination of the maximum dosage of medicine of the present invention

[0027] With reference to the literature method (Chinese medicine pharmacology research methodology, edited by Chen Qi. People's Health Publishing House, 1993, 1st edition, 112), get 40 Kunming mice, male and female, body weight 20 ± 2g, divided into normal control group and normal control group. The administration group was given 0.4mL of medicine per 10 grams of body weight of the mice (the maximum volume had been reached), twice a day (the normal control group was given an equal volume of normal saline, and the medicine concentration was 1g / mL). Immediately after administration, observe for up to 6 hours, then observe every day for 14 consecutive days; observe for dissection on the 8th day, and observe continuously for 7 days. The coat of the animal is smooth, lively, the natural hole is clear, and the urine and stool are normal. There is no significant difference between the c...

Embodiment 2

[0028] Embodiment 2 The effect of the medicine of the present invention on the rabbit platelet aggregation in vitro induced by adenosine diphosphate (ADP)

[0029] Refer to the literature method (Wu Yuan, Guo Hongbao, Wang Tiejun, etc. Comparison of the effects of several traditional Chinese medicine components on platelet aggregation in rabbits in vitro. Chinese Clinical Pharmacology and Therapeutics. 2007, 12 (9): 1047-1051) 36 healthy home Rabbits, half male and half female, weighing 2-2.5 kg, provided by the Institute of Animals, Sichuan Academy of Medical Sciences, production batch number: Dossy-2012-05. Rabbits were randomly divided into 6 groups, 5 drug groups with different concentrations (50, 25, 12.5, 6.25 and 3.125 mg / mL) and 1 blank control group. Rabbits were anesthetized by intraperitoneal injection of 10% chloral hydrate, blood was collected from the common carotid artery, collected in plastic test tubes, anticoagulated with 3.2% sodium citrate, and the volume r...

Embodiment 3

[0033] Embodiment 3 Replication of rat inferior vena cava thrombosis model

[0034] Principle: After ligation of the inferior vena cava, local blood stasis and hypoxia lead to damage of vascular endothelial cells and activation of the endogenous coagulation system. In addition, platelets and locally formed coagulation factors also stay locally due to blood flow obstruction, resulting in thrombus formation. This method is mostly used to study the effect and mechanism of drugs in inhibiting thrombus formation in vivo.

[0035] Referring to the literature method (Hu Sanjue, Tian Qiaolian, Gu Jianwen, etc. A new animal model of thrombosis in vivo. Journal of Fourth Military Medical University No. 14 (1): 11-13), 48 rats were randomly divided into 6 groups, respectively Normal control group (normal saline), model group (normal saline), positive control aspirin group, medicine high, middle and low dose groups of the present invention, respectively stomach (ig) normal saline, aspiri...

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Abstract

The invention discloses a compound traditional Chinese medicinal composition for treating venous thrombosis and chemotherapeutic phlebitis, as well as preparation and an application of composition, belonging to the technical field of medicines. The compound traditional Chinese medicinal composition is prepared from the following components in parts by mass: 3-30 parts of earthworm, 3-30 parts of notoginseng, 3-50 parts of herba lycopi, 2-30 parts of pungent litse fruit, 3-60 parts of raw radix paeoniae alba, 4-60 parts of dried ginger and 10-30 parts of cinnamon. The preparation method comprises the following steps: (1) refluxing and extracting the notoginseng, the pungent litse fruit and the earthworm by ethanol, separating extract and dregs; (2) extracting the dregs in the step (1), the herba lycopi, the raw radix paeoniae alba, the dried ginger and the cinnamon by water, and separating extract and dregs; and (3) combining the extracts in the steps (1) and (2), and concentrating to obtain thick extract. The compound traditional Chinese medicinal composition has strong effects of resisting platelet aggregation and thrombosis, and has good thrombolysis and anti-inflammation effects on venous thrombosis and chemotherapeutic phlebitis in clinical application.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine compound composition for treating venous thrombosis and chemotherapy phlebitis and its preparation and application. Background technique [0002] Thrombotic disease is a type of disease that seriously endangers human health and life, and its morbidity, disability and mortality are high. Clinically common thrombotic diseases include acute coronary syndrome, acute ischemic cerebrovascular disease , thrombosis in diabetic patients, thromboangiitis obliterans, thrombosis caused by acute tumors, etc. [0003] Thrombosis is a common and frequently-occurring disease that seriously endangers human health. Thrombosis and infarction play the most important role in myocardial infarction, cerebral infarction and pulmonary infarction. There are about 13 million cardiovascular deaths worldwide each year. In my country, the mortality rate of heart disease and c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A23L1/29A61P7/02A61P9/14A61K35/56A23L33/00
Inventor 杨同华李立纪苏勉诚陈志松赵仁彬沈晓梅
Owner FIRST PEOPLES HOSPITAL OF YUNNAN PROVINCE
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