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A kind of Tibetan medicine composition with antithrombotic effect

A composition and antithrombotic technology, applied in the field of medicine, can solve problems such as high cost and toxic and side effects

Active Publication Date: 2020-02-28
SHANDONG JINHE DRUG RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the drug treatment of thrombosis mainly includes chemical drugs, biological enzymatic hydrolysis, etc., but its high cost and side effects have been criticized

Method used

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  • A kind of Tibetan medicine composition with antithrombotic effect
  • A kind of Tibetan medicine composition with antithrombotic effect
  • A kind of Tibetan medicine composition with antithrombotic effect

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0022] Experimental example 1, in vitro screening experiment of antithrombotic effect

[0023] 1. Test materials and instruments

[0024] 1.1 Drugs and reagents

[0025] Compound Danshen dripping pills, Tianjin Tasly Pharmaceutical Co., Ltd., batch number: 120413; urokinase, Hangzhou Aoya Biotechnology Co., Ltd., batch number: 1301166; bovine fibrin (sigmaF8630); thrombin (sigmaT4648); PBS buffer solution PH7·2- 7·4; Beijing Zhongshan Jinqiao Biotechnology Co., Ltd.

[0026] 1.2 Instruments

[0027] Vertical pressure steam sterilizer (LDZX-50FBS, Shanghai Shenan); desktop centrifuge (H3, Sigma); electric constant temperature blast drying oven (101, Shanghai Pengshun Scientific Instrument Co., Ltd.); electronic constant temperature water bath (DZKW -C type, Huanghua City Unloading Comprehensive Electric Appliance Factory); electric heating constant temperature incubator (Shanghai Fuma Experimental Equipment Co., Ltd.); measuring ruler.

[0028] 2. Sample preparation

[002...

experiment example 2

[0066] Experimental example 2. Effect on thrombus formation in rats induced by electrical stimulation

[0067] 1. Reagent samples

[0068] Compound Danshen Dropping Tablets, Jilin Jinmaitong Pharmaceutical Co., Ltd., Z22025356; the test solution of each sample group was diluted to contain 0.2g of the original medicinal material per 1mL, the same as in Experimental Example 1. BT87-Ⅲ In Vivo Thrombosis Tester, Baotou Medical College Cardiovascular Laboratory.

[0069] 2. Animals and groups

[0070] Take 70 healthy female Wistar rats, weighing 180-220g, and feed them adaptively for 3 days, and randomly divide them into: blank group—gavage with equal volume of normal saline; 5 sample groups, namely F0 group, FW group, and FA group , FB-water group and FB-ester group——each sample group was given corresponding samples by intragastric administration, and the dose was 2g of raw medicinal materials / kg body weight; positive control group——administered 0.3g / kg of Compound Danshen Table...

Embodiment 1

[0080] Embodiment 1, a kind of Tibetan medicine composition with antithrombotic effect, is composed as follows:

[0081] 100g of agarwood, 100g of nutmeg, 100g of jujube, 175g of woody fragrance, 100g of myrobalan, 75g of kapok, 15g of longan, 5g of ferulae, 10g of bison heart, 50g of betel nut; Decoct in water for 2 times, 1 hour each time, and concentrate until dry to obtain the water extract.

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PUM

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Abstract

The invention discloses a Tibetan medicine composition with antithrombotic effect. On the basis of a traditional eight-medicine aquilaria wood pill, addition and deletion of medicinal materials in a prescription for the pill are carried out so as to allow the pill to have improved prevention and treatment effect on thrombotic diseases. Results of in-vitro and in-vivo antithrombotic experiments show that the traditional Tibetan eight-medicine aquilaria wood pill has strong antithrombotic effect after deletion of olibanum and travertine and presents substantially improved antithrombotic effect after further addition of long pepper, Chinese asafoetida and the dried heart of Bosgrunnien Linnaens, especially after addition of betel nut, and the improved antithrombotic effect is obviously better than the effect of the traditional eight-medicine aquilaria wood pill.

Description

technical field [0001] The invention relates to a Tibetan medicine composition with antithrombotic effect, which belongs to the field of medicine. Background technique [0002] Thrombosis is currently one of the most important causes of cardiovascular and cerebrovascular diseases. Prevention and slowing down of thrombus formation can greatly reduce the formation of stroke and other diseases. At present, there are mainly chemical drugs and biological enzymatic hydrolysis for the drug treatment of thrombosis, but their high cost and toxic side effects have been criticized all the time. Traditional Chinese medicine and Tibetan medicine have clear effects in the treatment of thrombotic diseases, and they are being used more and more in clinical practice. [0003] Bawei Chenxiang Wan is a traditional Tibetan medicine, which has the functions of clearing away heat, nourishing the heart, calming the nerves, and resuscitation. For febrile disease attacking the heart, coma and deli...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/835A61K36/889A61P7/02
CPCA61K35/34A61K36/185A61K36/22A61K36/23A61K36/285A61K36/67A61K36/835A61K36/889A61K2300/00
Inventor 邵成雷姬涛杨文钰孙绪丁王海苹
Owner SHANDONG JINHE DRUG RES DEV
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