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Quality control method of four-time treated rhizoma cyperi decoction pieces

A quality control method, the technology of four-manufacture Cyperus fragrans, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problem of inability to achieve stable quality, controllable process specifications, lack of quality control methods of modern scientific and technological means, and limited inheritance. and promotion and application to achieve the effect of improving the pharmacological effect of anti-dysmenorrhea

Active Publication Date: 2014-11-19
江西龙开河中药饮片有限公司
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AI Technical Summary

Problems solved by technology

In Jiangxi, Fujian, Taiwan and other surrounding areas, four methods are commonly used to process Cyperus cyperi. The processing technology is unique and enjoys a high reputation in the pharmaceutical industry. However, the processing technology is still mainly based on the inheritance of experience and lacks modern scientific and technological means. The quality control method cannot achieve "stable quality, standardized process, and controllable decoction pieces", which largely limits the inheritance, promotion and application of its unique processing technology

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  • Quality control method of four-time treated rhizoma cyperi decoction pieces

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Embodiment 1

[0033] (1) High performance liquid chromatography determination conditions:

[0034] Chromatographic column: Diamonsil C18; detection wavelength: 250nm; flow rate: 1.0mL / min; injection volume: 20μL; column temperature: room temperature; mobile phase: methanol and double distilled water; elution procedure: gradient elution;

[0035] (2) Preparation of reference substance solution:

[0036] Precisely measure 0.05mL of α-cyperone reference substance, place it in a 10mL volumetric flask, dilute to the mark with 95% ethanol, shake well, and obtain a reference substance solution with a concentration of 5ug / mL;

[0037] (3) Establishment of standard equation:

[0038] Precisely draw the reference substance solution to be prepared into a series of concentrations, inject the liquid chromatograph, analyze by the chromatographic conditions of step (1), measure the peak area, take the amount of the reference substance as the abscissa, and the peak area value as the ordinate to obtain the...

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Abstract

The invention discloses a quality control method of four-time treated rhizoma cyperi decoction pieces. The quality control method comprises the steps: establishing a four-time treated rhizoma cyperi HPLC fingerprint spectrum, and with an active ingredient alpha-cyperone as a benchmark peak, calculating the content of alpha-cyperone in the benchmark peak; and allowing fingerprint peaks of other main active ingredients to take alpha-cyperone as a reference, calculating the relative contents of the fingerprint peaks of the active ingredients according to alpha-cyperone. The method has operability, can control the relative contents of other unknown main effective ingredients only with the known reference substance alpha-cyperone ingredient content, and is a scientific method achieving control of the quality of the four-time treated rhizoma cyperi decoction pieces. The method is simple, is easy to popularize, reduces the use amount of the reference substance, solves the problems that a market monomeric material reference substance is insufficient and expensive, makes the quality of the four-time treated rhizoma cyperi decoction pieces stable, enhances the pharmacological function, and is conducive to promote rapid development of traditional Chinese medicine industries.

Description

technical field [0001] The invention relates to the technical field of quality control of traditional Chinese medicines, in particular to a quality control method for four-process Rhizoma Rhizoma Rhizoma Rhizoma Rhizome. Background technique [0002] Cyperus cyperus is the dry rhizome of Cyperus rotundus L., a Cyperaceae plant. First recorded in "Bielu of Famous Doctors", it has the effects of soothing the liver and regulating qi, regulating menstruation and relieving pain. It is an important medicine for regulating menstruation and relieving pain in gynecology. Menstrual disorders, dysfunctional uterine bleeding and other gynecological diseases. Since the pharmacological action and chemical composition of Rhizoma Cyperi have changed greatly before and after processing, the processed products are often used as medicine in clinical practice. [0003] Traditional Chinese medicine processing is an ancient pharmaceutical technology. Many existing traditional processing techniq...

Claims

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Application Information

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IPC IPC(8): G01N30/88
Inventor 郭慧玲胡律江赵晓娟胡志方李淑雯
Owner 江西龙开河中药饮片有限公司
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