Application of berberine in preparing drug for treating sterility of ovulation disturbance

An infertility, berberine technology, applied in the field of medicine, can solve the problems of general curative effect, ovarian hyperstimulation symptoms, high price and so on

Active Publication Date: 2014-12-10
吴效科
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by the present invention is to overcome the relatively large side effects (such as: multiple pregnancy, ovary enlargement, ovarian cyst rupture, ovarian hyperstimulation syndrome, arterial thromboembolism, hot flashes, heating and liver and kidney disease) that existing ov

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  • Application of berberine in preparing drug for treating sterility of ovulation disturbance

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Embodiment 1

[0009] Application of embodiment 1 berberine (berberine) in the preparation of the medicine for the treatment of ovulation disorder infertility

[0010] 1. Inclusion criteria of clinical cases

[0011] ①Women of childbearing age have normal sexual life after marriage, the man’s reproductive function is normal, and they live together without contraception for 1 year but fail to conceive. Primary infertility refers to those who have never conceived after marriage; Those who have not conceived without contraception and have not conceived for more than one year.

[0012] ②Diagnostic criteria for follicular maturation disorder and anovulation: ①The basal body temperature has been recorded continuously for more than 3 months in monophasic or atypical biphasic phase; Ovulation cycle of small follicle: follicle diameter > 14mm, but 30mm, unruptured follicle luteinized). There was no secretion peak in urine LH determination.

[0013] ③ There are childbearing requirements.

[0014]...

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Abstract

The invention discloses an application of berberine in preparing a drug for treating sterility of ovulation disturbance. Studies show that berberine can promote ovulation of a patient suffering from infertility of ovulation disturbance; and during a treatment process, the probability of twins and triplets is far lower than that of an ovulation induction drug of clomiphene, thereby greatly reducing risks of multiple pregnancy and occurrence of pregnancy complications, and reducing occurrence of adverse reactions. Besides, the drug is cheap and can be accepted by the patient easily. The drug is attractive in price and quality and is worth of popularization and application. Therefore, the application of berberine in preparing the drug for treating the sterility of ovulation disturbance is provided by the invention. The novel curative effect becomes a novel indication of berberine, broadens clinical application capacity of berberine, and will achieve enormous social benefits and economic benefits.

Description

technical field [0001] The invention relates to a new use of berberine, in particular to the use of berberine in the preparation of medicines for treating ovulatory infertility. The invention belongs to the technical field of medicine. Background technique [0002] Infertility is a common disease in gynecology with complex etiology. Ovulation disorder is one of the main causes of female infertility, accounting for 25%-35% of infertility. Western medicine believes that the reasons for anovulation are as follows: ① hypogonadism caused by hypothalamus-pituitary failure, which is characterized by blood luteinizing hormone (Luteinizing Hormone, LH), follicle-stimulating hormone (Follicle-stimulating hormone, FSH) and Low estrogen level; ②Hypothalamus-pituitary dysfunction: It is characterized by abnormal secretion ratio of gonadotropin LH / FSH, such as polycystic ovary syndrome, abnormal increase in the frequency and amplitude of LH secretion, and relatively insufficient FSH secr...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P15/08
CPCA61K31/4375
Inventor 吴效科张跃辉马红丽沈文娟李瑞丽
Owner 吴效科
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