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31 results about "Chlidanthine" patented technology
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The alkaloid chlidanthine (3) is a positional isomer of Gal, however it has a very weak inhibitory effect against AChE in comparison to Gal and sanguinine. Our results can explain very well such behavior.
Extraction method of high-purity coptis total alkaloid
ActiveCN103393780ALow costEasy to processMetabolism disorderCardiovascular disorderCoptisineCalcium hydroxide
The invention relates to an extraction method of high-purity coptis total alkaloid, which comprises the following steps: preparing a raw material (coptis or coptis fibril or coptis ash), pulverizing (not required if the raw material is coptis fibril or coptis ash), immersing in 0.1-5% sulfuric acid, heating and extracting four times, filtering, neutralizing with calcium oxide (or calcium hydroxide), filtering, washing the precipitate, preconcentrating, regulating the acid, precipitating with sodium chloride, filtering, recovering alkaloid from the mother liquor, and drying the precipitate to obtain the coptis total alkaloid product. The main active components of the product are coptis effective components, such as berberine, coptisine, palmatine, epiberberine, jateorhizine and the like; the coptis total alkaloid content is more than 50%; and the berberine content is more than 25%. The product provided by the invention has favorable actions of lowering blood sugar and blood fat, losing weight and the like, and is an ideal raw material for treating diabetes and cardiovascular diseases.
Owner:重庆伊士腾生物科技有限公司
Coolant, medicinal ice-bag comprising same and its use method
The present invention relates to a cooling agent, and medicated ice-bag with said cooling agent and its application method. The cooling agent of said medicated ice-bag is a compound liquor whose composition contains (by volume ratio) 20% of absolute ethyl alcohol, 10% of glycerol, 20% of calcium chloride, 10% of sodium chloride, 1% of berberine and 39% of water. It does not ice at 55 deg.C below zero, and it is made into a flocculent material, its thermal eapacity is 2 calorie / g / deg.C, and it can absorb lots of heat quantity.
Owner:李昌德
Kutkin derivative, preparation method and application thereof
ActiveCN1923790AAnti-immune activityHas a cartilage protective effectOrganic chemistrySkeletal disorderNitrationStructural formula
The invention discloses a derivant of kutkin with chemical structural formula as formula I, wherein R1 is NO2, NH2 or amide; R2 is H, carbonyl or diaminocarbonyl. The preparing method comprises the following steps: nitrating kutkin to obtain kutkin derivant substituted by nitro group or kutkin derivant based on substituted nitro group; or kutkin derivant substituted by acetylamino.
Owner:JINAN UNIVERSITY
Feature-beautification and skin-care product and medicinal composition for treating burn and scald
InactiveCN107929098ARemove scarsReduce swelling and relieve painAntibacterial agentsCosmetic preparationsSaturated aqueous solutionBorax
The invention discloses a feature-beautification and skin-care product and a medicinal composition for treating a burn and a scald. The medicinal composition is prepared from the following componentsof polyglutamic acid, ceramide, niacinamide, vitamin E, berberine, a calcium hydroxide saturated aqueous solution, oleum camelliae, radix sanguisorbae powder, borneol, borax and the balance of ointment. Through clinical application and observation, the medicinal composition has the effects of quickly dispersing a swelling and relieving pain for positions suffering from the burn and the scald and promoting a wound surface to heal, effectively inhibiting bacteria on the wound surface from breeding and preventing cross infection. Meanwhile, in a process of treating tissue suffering from the burnand the scald, a skin is promoted to be repaired at the same time; the formation of scars is reduced; further, an untoward effect does not exist; particularly, after wound surfaces of large-area burnand scald are treated, marks of the scars of the treated skin are light in color, and in a condition that the feature-beautification and skin-care product provided by the invention is insistently used, the scars of the burn and the scald can be eliminated.
Owner:杨益文
Derivative of Kutkin dimer analog JJA-D0 or its pharmaceutically acceptable salt, preparation method and use thereof
ActiveCN108947859ANovel structureSimple preparation processSenses disorderNervous disorderDiseaseNo donors
The invention relates to a derivative of Kutkin dimer analog JJA-D0 or its pharmaceutically acceptable salt, a preparation method and use thereof. The compound has a structure shown as a general formula (I). According to the invention, an alkyl group, an aryl group, a heteroaryl group, an alkoxycarbonylalkyl group, an acyl group, a sulfonate group, an antioxidant group such as a lipoic acid group,a H2S donor group such as a cysteine group, and a NO donor group such as a nitrate group are introduced to JJA-D0, and a series of structurally novel compounds can be synthesized and disclosed. The compounds inhibit NADPH oxidase and have superior anti-oxidation and anti-inflammatory pharmacological mechanisms by comparing with Kutkin, the compounds also have donor groups that provide NO and H2S,can further enhance pharmacological activity, and can be a new class of multifunctional compounds. The disclosed JJA-D0 derivative can be used for preparing health products or drugs for prevention ortreatment of diseases associated with NADPH oxidase, diseases associated with free radicals, diseases associated with inflammation, diseases associated with NO, and diseases associated with H2S.
Owner:JINAN UNIVERSITY
Application of berberine in preparing drug for treating sterility of ovulation disturbance
ActiveCN104188966AEasy to acceptLow priceOrganic active ingredientsSexual disorderBerberineComplications of pregnancy
The invention discloses an application of berberine in preparing a drug for treating sterility of ovulation disturbance. Studies show that berberine can promote ovulation of a patient suffering from infertility of ovulation disturbance; and during a treatment process, the probability of twins and triplets is far lower than that of an ovulation induction drug of clomiphene, thereby greatly reducing risks of multiple pregnancy and occurrence of pregnancy complications, and reducing occurrence of adverse reactions. Besides, the drug is cheap and can be accepted by the patient easily. The drug is attractive in price and quality and is worth of popularization and application. Therefore, the application of berberine in preparing the drug for treating the sterility of ovulation disturbance is provided by the invention. The novel curative effect becomes a novel indication of berberine, broadens clinical application capacity of berberine, and will achieve enormous social benefits and economic benefits.
Owner:吴效科
Combination drug used for killing genitals microorganisms of female Tibetan mastiffs and assisting reproduction
The invention relates to a combination drug used for killing genitals microorganisms of female Tibetan mastiffs and assisting reproduction. The combination drug contains matrine, podophyllotoxin, berberine, vitamin C, etoposide and antifungal drugs in western medicine.
Owner:王爽
Anti-inflammatory medicament capable of treating beriberi and preparation method thereof
InactiveCN104027467AReduce generationEliminate infectionAntimycoticsTetracycline active ingredientsSulfanilamideOxytetracycline
The invention discloses an anti-inflammatory medicament capable of treating beriberi and a preparation method thereof. The anti-inflammatory medicament is prepared from the following raw materials by weight percent: 2-10% of oxytetracycline, 2-10% of berberine, 2-10% of compound sulfanilamide dimethyl, 2-10% of analgin, 8-16% of paracetamol caffeine aspirin powder, 2-10% of norfloxacin, and 40-80% of traditional Chinese medicine mixed liquor, wherein the traditional Chinese medicine mixed liquor comprises the following components in parts by weight: 50-100 parts of eggplant stem, 20-50 parts of pepper stem, 70-100 parts of peanut shell, 30-60 parts of sunflower seed shell, 20-40 parts of towel gourd seedling, 10-30 parts of almond shell and 30-50 parts of scandent hop, and is prepared through dipping cook by 4000-6000 parts of water and filtering. The anti-inflammatory medicament combines the traditional Chinese medicine and western medicine, can be used for effectively reducing foot fungus, eliminating fungal infection, relieving pain and itching, and getting rid of foot odor, becomes effective rapidly, and has high cure rate.
Owner:王诺生
Acne removing lotion, acne removing medicine composition and preparation method of acne removing medicine composition
InactiveCN104958652AStimulate active detoxification and muscle growthNo acne scarsOrganic active ingredientsDermatological disorderCell activityChloramphenicol
The invention relates to an acne removing lotion, an acne removing medicine composition and a preparation method of the acne removing medicine composition. Effective components of the acne removing lotion are prepared from the following raw materials in parts by weight: 15 to 25 parts of meleumycin, 5 to 15 parts of vitamin, 15 to 25 parts of chloramphenicol, 5 to 15 parts of berberine and 15 to 25 parts of ethanol. According to the acne removing lotion and the acne removing medicine composition disclosed by the invention, clogged pores can be quickly dredged, further skin endotoxins are discharged out of the body through the dredge pores to kill skin bacteria, the cell activity is stimulated for detoxification and promotion of tissue regeneration, so that acnes are thoroughly removed, and the skin becomes fine and glossy, smooth and white-skinned, and no acne scars are formed.
Owner:澹钊
Silver ion no-clean disinfectant as well as preparation method and application thereof
PendingCN114522110AStrong sterilizationLong-term antibacterialCosmetic preparationsToilet preparationsBerberineAlcohol
The invention provides a silver ion no-wash disinfectant as well as a preparation method and application thereof. The silver ion no-wash disinfectant is prepared from the following raw materials in percentage by weight: 50 to 70 percent of absolute ethyl alcohol, 0.001 to 0.05 percent of silver nitrate, 1 to 10 percent of rhizoma coptidis extracting solution, 0.5 to 5 percent of stabilizer, 0.01 to 1 percent of pH regulator, 0.1 to 2 percent of thickener, 1 to 5 percent of humectant and the balance of water, wherein the coptis chinensis extract contains berberine, and the concentration of the berberine in the washing-free disinfectant is 0.1 mg / mL to 1 mg / mL. The no-clean disinfectant disclosed by the invention has the advantages of safety, good sterilization and bacteriostasis effects, difficulty in generating drug resistance and the like.
Owner:HUNAN ANSON MEDICAL POLYMER MATERIALS
Medicine for treating psoriasis and its preparation method
InactiveCN101104046AEfficient absorptionEffective antivirusDermatological disorderPlant ingredientsBerberineExternal application
The invention relates to the medicine and the preparation method for treating the psoriasis. The invention delivers the smashed ripe nuts of hydnocarpus and fructus bruceae, powdered Yisaoguang, a smashed berberine tablet without the sugar-coat or the berberine liquid medicine, peeled and mashed garlic and the edible vinegar essence under the normal temperature of 17-22 DEG C into a container according to the ratios of weights of four point zero-four point five to zero point thirty five-zero point fifty five to zero point two-zero point four to zero point fifty five-zero point seventy five to ten-eleven to forty eight-fifty two, and then the materials are soaked under the closed condition, after two hours of soaking, the liquid is exactly the drug for external application.
Owner:姜证中
Composite callus ointment
The invention discloses a composite callus ointment. The composite callus ointment is characterized by being prepared from the following components by ratio: 6.7% of oxytetracycline, 6.7% of berberine, 6.7% of Yunnan Baiyao, 3.3% of metronidazole, 3.3% of vitamin C, 3.3% of cimetidine, 2.3% of complex vitamin B, 1% of borneol and 66.7% of vaseline. The problems that an existing external ointment is poor in treatment effect on pain and itching caused by anorectal disease and chapped skin is solved; and the composite callus ointment is suitable for being smeared by patients with anal pruritus, anal fissure and chapped skin.
Owner:于玲玲
External ulcer powder
InactiveCN104688768AGood for treating ulcersTetracycline active ingredientsDermatological disorderBerberineVitamin C
The invention relates to an external ulcer powder, which is characterized by including: 15% of oxytetracycline, 15% of berberine, 10% of compound sulfamethoxazole, 10% of metronidazole, 15% of composite vitamin B, 15% of vitamin C, 10% of cimetidine, 7% of calcium, and 3% of chlorpheniramine. The external ulcer powder provided by the invention solves the problem that existing external ulcer powder is inapplicable to treatment of bedsore and other skin mucosa ulcer, scalds, non healing wounds and other diseases, and is suitable for treatment of various infantile febrile convulsion patients.
Owner:于玲玲
Derivatives of berberine dimer analog jja-d0 or pharmaceutically acceptable salts, preparation methods and uses thereof
ActiveCN108947859BNovel structureSimple preparation processSenses disorderNervous disorderDimerDisease
Owner:JINAN UNIVERSITY
Purification method of berberine or its hydrochloride
The invention discloses a method for purifying berberine or its hydrochloride, which comprises: mainly including the reaction of the starting material mainly containing berberine, berberine hydrochloride or berberine sulfate with salt II, and converting it into an intermediate salt of berberine, Finally, the intermediate salt of berberine is converted into berberine or its hydrochloride. The present invention converts the starting material mainly containing berberine, berberine hydrochloride or berberine sulfate into an intermediate salt of berberine, removes impurities, and then converts the intermediate salt of berberine into berberine or its hydrochloride, The final product has a total impurity content of less than 0.2% and a single impurity content of less than 0.1%, which further ensures the safety of the drug.
Owner:JIANGXI FUSHINE PHARMA CO LTD
High performance liquid chromatography detection method of berberine intermediate
The invention belongs to the field of medical intermediate detection, and particularly discloses a high performance liquid chromatography detection method of berberine intermediates, the intermediates are homopiperony lamine, the chemical name is 3, 4-methylenedioxy phenylethylamine, and the detection method comprises the steps of determination of chromatographic conditions, preparation of a test solution, preparation of a reference solution and preparation of a standard substance. Calculating a standard curve; respectively and precisely measuring the test solution and the reference solution, injecting into a liquid chromatograph, recording a chromatogram, and calculating the content by peak area according to an external standard method. The detection method disclosed by the invention is good in specificity, high in sensitivity and high in separation degree, and durability, linearity and the like can meet requirements.
Owner:SUZHOU CHIEN SHIUNG INST OF TECH
A kind of berberine anti-tumor platinum (ii) complex and its synthesis method and application
ActiveCN110105402BThe synthetic route is simpleMild reaction conditionsPlatinum organic compoundsAntineoplastic agentsStructural formulaPharmaceutical Substances
The invention relates to a berberine anti-tumor platinum (II) complex, its synthesis method and the application of the complex in the preparation of anti-tumor drugs. The synthesis method of the berberine anti-tumor platinum (II) complex comprises the following steps: (1) dissolving the brominated berberine derivative, potassium halide and lutidine amine in a solvent, and reacting at 90° C. to obtain B ‑TFA ligand; (2) the B‑TFA ligand prepared in step (1) and dichlorobis(dimethylsulfoxide) platinum (II) are dissolved in acetonitrile solution, and carry out coordination reaction 4~6 Hours, the product was washed and dried to obtain. The present invention uses the brominated berberine derivative B-TFA as the active ligand for the first time to synthesize its platinum complex, which exhibits superior anti-tumor activity and targeting in vivo and in vitro, has potential medicinal value, and is expected to be used in various Preparation of antineoplastic drugs. The structural formula of the berberine anti-tumor platinum (II) complex is as follows:
Owner:YULIN NORMAL UNIVERSITY
Pharmaceutical composition for treatment of inflammatory skin diseases, preparation method and use thereof
InactiveCN107625799AHeat-clearing and detoxifyingWith swelling and pain reliefAntibacterial agentsCosmetic preparationsTherapeutic effectGynura formosana
Belonging to the field of drugs or health care products, the invention relates to a pharmaceutical composition for treatment of inflammatory skin diseases, in particular to a pharmaceutical composition for treatment of acnes. The pharmaceutical composition comprises the following raw materials: 8.5-11.5 parts by weight of Chinese herb Pien Tze Huang, 68-92 parts by weight of Gynura formosana, 5.1-6.9 parts by weight of hesperidin, and 3.4-4.6 parts by weight of berberine. Clinical research shows that the pharmaceutical composition not only has obvious therapeutic effect on acnes, has a clinical total effective rate up to 90%, but also can effectively improve pigmentation and scars left after acne fading, and has little adverse reaction in clinical application and high safety, thus having good clinical application prospect.
Owner:ZHANGZHOU PIEN TZE HUANG PHARM
Plant compound special drug for killing insects, bacteria and increasing production of strawberry
ActiveCN107018998BWide variety of sourcesLow costBiocideDead animal preservationBiotechnologyFragaria
The present invention discloses a special insect disinfestation and sterilization agent for strawberry, wherein the special insect disinfestation and sterilization agent comprises, by weight, 20-30 parts of berberine, 25-36 parts of wuyiencin, 10-30 parts of metaldehyde, 11-21 parts of phoxim, 8-15 parts of dipterex, 5-8 parts of chlorpyrifos, 10-20 parts of litchi shell, and 5-15 parts of willow leaf. The invention further discloses a preparation method of the special insect disinfestation and sterilization agent. According to the present invention, by compounding the chemical reagent and the plant, the good insect disinfestation and sterilization effect is provided; through the reasonable ratio, the effective insect disinfestation and sterilization effect can be ensured, and the good economic and the ecological benefits can be obtained; the raw material source is wide, the cost low, and the insect disinfestation and sterilization agent is suitable for large area promotion application; and the special insect disinfestation and sterilization agent can be subjected to one time use from the reality so as to reduce the labor operation.
Owner:武汉木兰金秋农业科技发展有限公司
A Mongolian medicine for clearing away heat and stopping bleeding and its manufacturing process
ActiveCN107582899BHas heat-clearing, cooling blood and hemostasis effectSmall toxicityOrganic active ingredientsInorganic phosphorous active ingredientsDiseaseCholic acid
The invention relates to medicine and a preparation technology thereof, namely heat clearing and hematostatic Mongolian medicine and preparation technology thereof. The Mongolian medicine is characterized by being prepared from the following active ingredients in parts by weight: 1 to 2 parts of gardenoside, 1 to 2 parts of rutin, 1 to 2 parts of carthamin, 1 to 2 parts of beta-sitosterol, 1 to 2parts of rheum emodin, 1 to 2 parts of glycyrrhizic acid, 1 to 2 parts of kutkin, 1 to 2 parts of rubican, 1 to 2 parts of alkannin, 1 to 2 parts of shellac resin, 3 to 5 parts of calcium carbonate, 3to 5 parts of calcium phosphate, 3 to 5 parts of amino acid, 2 to 3 parts of cholic acid and 2 to 3 parts of calculus bovis. The Mongolian medicine has the beneficial effects of heat clearing, bloodcooling and hematostatic effects, obvious curative effects on hemorrhage syndromes of hematemesis, hemafecia, menorrhagia, traumatic bleeding, liver diseases and the like, low toxic and side effect, wide suitable crowd range, convenience in taking, convenience in digestion and absorption and quick effect; thus, the Mongolian medicine hopefully becomes typical medicine for treating lung diseases.
Owner:内蒙古民族大学附属医院
Purification method and crystal form of berberine or its salt
ActiveCN111205285BHigh purityEasy to operateOrganic chemistry methodsPharmaceutical drugMedicinal chemistry
Owner:JIANGXI FUSHINE PHARMA CO LTD
Novel berberine derivative as well as synthesis method and application thereof
ActiveCN112250680AGood myocardial targetingGood intake ratioIsotope introduction to heterocyclic compoundsRadioactive preparation carriersBerberineIsoquinoline
The invention discloses a novel berberine derivative as well as a synthesis method and application thereof, belongs to the field of imaging agents, and aims to derive the structure of isoquinoline alkaloid berberine, optimize derived sites on the basis of an early stage and introduce an F-containing side chain to prepare a series of probes with a myocardial targeting property. A 18F marker of theseries of compounds is successfully prepared through a marking experiment of positron nuclide 18F; the 18F-labeled novel berberine derivative is higher in myocardial uptake, raw materials are easy toobtain, the synthesis cost of a molecular probe is reduced, and clinical transformation is facilitated.
Owner:WEST CHINA HOSPITAL SICHUAN UNIV
A kind of dihydromyricetin-berberine hydrochloride pharmaceutical co-crystal and its preparation method
ActiveCN110054606BEasy to prepareClear crystal structureOrganic chemistryNatural extract food ingredientsPharmaceutical drugBerberine hydrochloride
The invention discloses a drug co-crystal of dihydromyricetin-berberine hydrochloride, which belongs to the technical field of drug crystallization. The present invention combines dihydromyricetin and berberine hydrochloride through intermolecular hydrogen bonding to form the dihydromyricetin-berberine hydrochloride drug eutectic. The preparation method of the invention is simple and easy, and the cost is low. The prepared dihydromyricetin-berberine hydrochloride drug eutectic structure is clear, without hygroscopicity, and the dissolution rate of dihydromyricetin and berberine hydrochloride in water is similar, and can be dissolved simultaneously, showing a synergistically enhanced effect on specific tumor cells. inhibition.
Owner:MINJIANG UNIV
Kutkin derivative, preparation method and application thereof
ActiveCN100584816CAnti-immune activityHas a cartilage protective effectOrganic chemistrySkeletal disorderNitrationStructural formula
The invention discloses a derivant of kutkin with chemical structural formula as formula I, wherein R1 is NO2, NH2 or amide; R2 is H, carbonyl or diaminocarbonyl. The preparing method comprises the following steps: nitrating kutkin to obtain kutkin derivant substituted by nitro group or kutkin derivant based on substituted nitro group; or kutkin derivant substituted by acetylamino.
Owner:JINAN UNIVERSITY
Coolant, medicinal ice-bag comprising same and its use method
InactiveCN1298303CAbsorb moreEasy to useMedical applicatorsHeat-exchange elementsGlycerolEngineering
Owner:李昌德
Fenofibric acid salt of berberine and analogue thereof, crystal form, preparation method and applications thereof
ActiveCN111138427AOrganic active ingredientsOrganic compound preparationBerberineBerberine hydrochloride
The invention discloses fenofibric acid salts of berberine and analogues thereof, a crystal form, a preparation method and applications thereof, wherein the fenofibric acid salt comprises fenofibric acid serving as an anion and berberine or a berberine analogue serving as a cation. According to the invention, the fenofibric acid salt of berberine or analogue thereof can be used for removing unnecessary cations from commercially available medicines, ie., choline cations in choline fenofibrate and / or chlorine ions in berberine hydrochloride, so that a certain side effect, including gastrointestinal irritation due to instability property of choline as an anion and high acidity of berberine hydrochloride, caused by the two pairing ions can be reduced.
Owner:JIANGXI FUSHINE PHARMA CO LTD
Extraction method of high-purity coptis total alkaloid
ActiveCN103393780BLow costEasy to processOrganic chemistryMetabolism disorderCoptisineCalcium hydroxide
The invention relates to an extraction method of high-purity coptis total alkaloid, which comprises the following steps: preparing a raw material (coptis or coptis fibril or coptis ash), pulverizing (not required if the raw material is coptis fibril or coptis ash), immersing in 0.1-5% sulfuric acid, heating and extracting four times, filtering, neutralizing with calcium oxide (or calcium hydroxide), filtering, washing the precipitate, preconcentrating, regulating the acid, precipitating with sodium chloride, filtering, recovering alkaloid from the mother liquor, and drying the precipitate to obtain the coptis total alkaloid product. The main active components of the product are coptis effective components, such as berberine, coptisine, palmatine, epiberberine, jateorhizine and the like; the coptis total alkaloid content is more than 50%; and the berberine content is more than 25%. The product provided by the invention has favorable actions of lowering blood sugar and blood fat, losing weight and the like, and is an ideal raw material for treating diabetes and cardiovascular diseases.
Owner:重庆伊士腾生物科技有限公司
Natural pharmaceutical composition, and preparation method and application thereof
InactiveCN103655775AObvious antagonismGood synergyDigestive systemPill deliveryBerberinePharmaceutical drug
The invention relates to a natural pharmaceutical composition, and a preparation method and application thereof. The natural pharmaceutical composition is composed of 2-7 parts of coptis / cinnamon water decoction concentrated extract, 3-7 parts of berberine and 4-6 parts of cinnamaldehyde. The composition has favorable curative effect on cancer chemotherapy related diarrhoea.
Owner:张宗升
Anti- P.aeruginosa pharmaceutical composition as well as preparation method and application thereof
InactiveCN112294807AImprove antibacterial propertiesConvenient sourceAntibacterial agentsOrganic active ingredientsBerberineDrug utilisation
The invention provides an anti- P.aeruginosa pharmaceutical composition as well as a preparation method and application thereof. The pharmaceutical composition comprises the following components: (1)berberine and / or halogenated berberine, and (2) 3, 4-dibromomaleimide. Compared with single use of the berberine or the halogenated berberine for resisting P.aeruginosa, the anti- P.aeruginosa pharmaceutical composition has the advantages that after the berberine, the halogenated berberine and the 3, 4-dibromomaleimide adjuvant are compatible, the anti- P.aeruginosa activity of the pharmaceuticalcomposition can be improved by 4 times or above compared with that of raw medicines (the berberine and the halogenated berberine). Due to the fact that the dosage of raw medicines is greatly reduced,the content of the medicines of the berberine and the halogenated berberine contained in the novel preparation can be reduced by 4 times or above compared with the concentration of the raw medicines,and toxicity and various adverse reactions caused by high-dosage medication of various berberine and halogenated berberine are effectively avoided.
Owner:TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Folic acid-berberine nano-drug and preparation method and application thereof
ActiveCN111298126AGood water solubilityIncrease varietyOrganic active ingredientsPharmaceutical non-active ingredientsAntiendomysial antibodiesEfficacy
The invention discloses a folic acid-berberine self-assembled targeting nano-drug and a preparation method thereof. Folic acid-berberine nano-drug molecules are prepared by designing the preparation method, self-assembly of indissolvable drugs is realized, and the water-soluble targeting nano-drug is obtained. The invention provides the preparation method of the folic acid-berberine nano-drug andapplication of the nano-drug in cancer treatment. The folic acid-berberine nano-drug provided by the invention has specific antibody response, can realize targeted drug release of the drug at a tumorsite, and has the advantages of being low in cost, high in stability, free of immunogenicity, capable of reducing toxicity accumulation and drug resistance, capable of exerting a good treatment effectdue to the low drug loading capacity and capable of being selectively delivered to tumor tissues.
Owner:SOUTHEAST UNIV
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