2 results about "Chlidanthine" patented technology

To provide an oral composition that has a high astringent effect and high storage stability of berberine. [Solution] An oral composition comprising (A) component: berberine, (B) component: hinokitiol, and (C) component: isopropylmethylphenols, wherein the content of component (B) is 0.001 to 0.5% by mass relative to the total mass of the oral composition, and the ratio of the mass of component (C) to the mass of component (B), expressed as component (C) / component (B), is 0.01 to 10.

This invention discloses a berberine-dimethylaniline photosensitizer, its preparation method, and its application, belonging to the field of biomedical technology. The method involves sequentially reacting berberine with magnesium methyl bromide via Grignard addition, followed by bromomethylation with N-bromosuccinimide, and basic condensation with dimethylaminobenzaldehyde, then demethylating under high temperature and vacuum to obtain the active berberine-dimethylaniline. Finally, it undergoes weakly alkaline treatment to obtain the inactivated berberine-dimethylaniline. This invention introduces the electron-donating group dimethylaniline onto the berberine backbone, constructing an electron push-pull structure that red-shifts the absorption wavelength, facilitating deeper tissue penetration. Furthermore, this photosensitizer maintains high activity in the weakly acidic microenvironment of tumors while remaining inactive under normal physiological conditions, thereby achieving intelligent "on-off" regulation based on pH differences, improving the safety and precision of photodynamic therapy for tumors.