10 results about "Chlidanthine" patented technology

The invention discloses a composition for treating intractable skin infection, sores and ulcers and inflammation as well as a preparation method and application of the composition, and belongs to the technical field of functional compositions. The composition is prepared from the following components in parts by mass: 1 to 5 parts of baicalin, 0.5 to 3 parts of antibacterial alkaloid, 2 to 6 parts of asiaticoside, 3 to 8 parts of salvianolic acid B, 1 to 4 parts of gallic acid, 5 to 10 parts of rhizoma bletillae polysaccharide, 3 to 10 parts of konjac glucomannan, 3 to 5 parts of chitosan, 8 to 20 parts of glycerol, 0.5 to 2 parts of genipin, 1 to 3 parts of calcium chloride, 1 to 3 parts of laurocapram and 40 to 80 parts of water. The antibacterial alkaloid comprises berberine or phellodendrine. Based on deep understanding of an intractable skin pathological mechanism, the components are scientifically matched, and the composition shows a remarkable synergistic effect in in-vitro antibacterial, anti-biofilm and anti-inflammatory experiments. The preparation process is simple, low in cost and suitable for industrial production.

The invention belongs to the technical field of biology and new medicine, and discloses a preparation method of acoustic resonance driven glycyrrhizic acid nano-composite responsive gel, glycyrrhizic acid is used as a drug carrying system, berberine, ursolic acid, baicalein, luteolinin, curcumin, baicalin or ginsenoside Rh2 is used as a water-insoluble natural small molecule drug, and the acoustic resonance driven glycyrrhizic acid nano-composite responsive gel is prepared. Glycyrrhizic acid is an amphiphilic compound composed of one molecule of glycyrrhetinic acid and two molecules of glucuronic acid, a hydrophobic cavity can be formed in a water environment to wrap the water-insoluble natural small molecule medicine, a glycyrrhizic acid nano-composite solution is formed, and meanwhile the solubility of the water-insoluble natural small molecule medicine such as baicalein is improved.

To provide an oral composition that has a high astringent effect and high storage stability of berberine. [Solution] An oral composition comprising (A) component: berberine, (B) component: hinokitiol, and (C) component: isopropylmethylphenols, wherein the content of component (B) is 0.001 to 0.5% by mass relative to the total mass of the oral composition, and the ratio of the mass of component (C) to the mass of component (B), expressed as component (C) / component (B), is 0.01 to 10.

The present invention provides novel methods for reducing or inhibiting advanced glycation end products (AGEs) in a subject, comprising administration to the subject a composition comprising an effective amount of dihydroberberine or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof; and an effective amount of ergothioneine or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof. The present invention also provides a composition comprising an effective amount of dihydroberberine or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof; and an effective amount of ergothioneine or a pharmaceutically acceptable salt, acid, ester, analog or derivative thereof, for reducing or inhibiting advanced glycation end products (AGEs) in a subject.

This invention discloses a berberine-dimethylaniline photosensitizer, its preparation method, and its application, belonging to the field of biomedical technology. The method involves sequentially reacting berberine with magnesium methyl bromide via Grignard addition, followed by bromomethylation with N-bromosuccinimide, and basic condensation with dimethylaminobenzaldehyde, then demethylating under high temperature and vacuum to obtain the active berberine-dimethylaniline. Finally, it undergoes weakly alkaline treatment to obtain the inactivated berberine-dimethylaniline. This invention introduces the electron-donating group dimethylaniline onto the berberine backbone, constructing an electron push-pull structure that red-shifts the absorption wavelength, facilitating deeper tissue penetration. Furthermore, this photosensitizer maintains high activity in the weakly acidic microenvironment of tumors while remaining inactive under normal physiological conditions, thereby achieving intelligent "on-off" regulation based on pH differences, improving the safety and precision of photodynamic therapy for tumors.

The application discloses a composition for treating stubborn skin infection, ulcer and inflammation and a preparation method and application thereof, and belongs to the technical field of functional compositions. The composition is prepared from components containing baicalin 1-5 parts, antibacterial alkaloids 0.5-3 parts, asiaticoside 2-6 parts, salvianolic acid B 3-8 parts, gallic acid 1-4 parts, white plant polysaccharide 5-10 parts, konjac glucomannan 3-10 parts, chitosan 3-5 parts, glycerol 8-20 parts, genipin 0.5-2 parts, calcium chloride 1-3 parts, laurazepam 1-3 parts and water 40-80 parts. The antibacterial alkaloids include berberine or phellodendrine. The application scientifically matches the above components based on deep understanding of the stubborn skin pathological mechanism, and the composition exhibits a significant synergistic effect in in-vitro antibacterial, antibiofilm and anti-inflammatory experiments. The preparation process is simple, the cost is low, and the application is suitable for industrial production.

The application provides a pharmaceutical composition for treating gynecological inflammation and a preparation method thereof, and belongs to the technical field of medicines. After being subjected to water extraction and alcohol extraction, Sophora flavescens, Phellodendri chinensis, Forsythia suspensa and Ligustrum lucidum are used to obtain traditional Chinese medicine water extracts and traditional Chinese medicine alcohol extracts; the traditional Chinese medicine water extracts are reacted with silver salt and copper salt to obtain traditional Chinese medicine water extract-metal ion complex; the traditional Chinese medicine water extract-metal ion complex is mixed with the traditional Chinese medicine alcohol extracts, sodium taurodeoxycholate, laurocapram and berberine to prepare nanometer drug delivery micelles; and the nanometer drug delivery micelles are added into a hydrogel of chitosan, poloxamer P407 and poloxamer P188 to prepare the pharmaceutical composition for treating gynecological inflammation. The prepared composition has excellent treatment effect and low toxicity, thereby reducing the cost and improving the treatment effect of gynecological diseases such as chronic pelvic inflammatory disease, chronic cervicitis, vaginitis and artificial abortion complications, and has a wide application prospect.

The application discloses a berberine zinc complex and a preparation method and application thereof. The berberine-triphenylpyridine derivative BerT is reacted with a zinc salt ZnCl2 to obtain a berberine-triphenylpyridine zinc complex BerT1, then the BerT1 raw material is respectively reacted with auxiliary ligands 1,2-bis(diphenylphosphino)ethane, 2-(1H-imidazo[4,5-f][1,10]phenanthroline-2-yl)quinolin-8-ol and 1,10-phenanthroline to synthesize the berberine zinc complexes BerT2-BerT4. The experimental results show that the berberine zinc complexes BerT1-BerT4 have good anticancer effect on human breast cancer MDA-MB-231 cells, and show superior in-vivo and in-vitro anti-tumor activity, have potential medicinal value, and can be more effective in treating human breast cancer in combination with the Bcl-2 selective inhibitor ABT-199, and are expected to be used in the preparation of various anti-tumor drugs.

The invention relates to a novel (3, 10-dimethoxy-12, 13-dihydroisoquinolo [3, 2-a] isoquinoline-7-hydrochloride)-dehydroberberine derivative DH-Ber-12 and an application thereof, and designs a brand new artificially modified dehydroberberine derivative, in particular to a novel (3, 10-dimethoxy-12, 13-dihydroisoquinolo [3, 2-a] isoquinoline-7-hydrochloride)-dehydroberberine derivative. In the berberine derivative, 3, 9-dimethoxy-5, 6-dihydroisoquinolo [3, 2-a] isoquinoline-7-hydrochloride (Ber-12) shows good performance in the aspects of transcriptional activation activity, solubility and colon cancer cell inhibition activity of RXR [alpha], and the performance of the berberine derivative is expected to be improved through structural modification of the berberine derivative. The invention discloses a novel (3, 10-dimethoxy-12, 13-dihydroisoquinolo [3, 2-a] isoquinoline-7-hydrochloride)-dehydroberberine derivative DH-Ber-12 and a preparation method of the novel (3, 10-dimethoxy-12, 13-dihydroisoquinolo [3, 2-a] isoquinoline-7-hydrochloride)-dehydroberberine derivative, and belongs to the technical field of medicinal chemistry. The key points of the technical scheme are as follows: the synthesis route is short, the operation is simple and easy, the product structure is novel, the performance is stronger than that of Ber-12, and the method is worthy of further popularization and research.

This invention discloses berberine derivatives of formula (I) and formula (II), wherein R1 is H, CH 3， R2 is CH3,CH2CH2Cl, and n is a natural number from 4 to 8. It exhibits good inhibitory effects on cancer cells and can be used as an anticancer drug. This invention also discloses its preparation method.