Derivatives of berberine dimer analog jja-d0 or pharmaceutically acceptable salts, preparation methods and uses thereof

A technology of JJA-D0 and berberine, which is applied in the field of medicine, can solve the problem of a single modifiable site of the parent compound, achieve the effects of inhibiting NADPH oxidase, simple preparation process, and low cost
CN108947859BActive Publication Date: 2021-06-11JINAN UNIVERSITY
3 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN ยท China
Patent Type
Patents(China)
Current Assignee / Owner
JINAN UNIVERSITY
Publication Date
2021-06-11

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The present invention relates to derivatives of berberine dimer analog JJA-D0 or pharmaceutically acceptable salts, preparation methods and uses thereof. The compound has the structure of general formula (I). The present invention introduces hydrocarbon groups, aryl groups, heteroaryl groups, alkoxycarbonyl groups, acyl groups, sulfonate groups, antioxidant groups such as lipoic acid groups, H 2 S donor groups such as cysteinyl, NO donor groups such as nitrate groups, etc., synthesized and disclosed a series of compounds with new structures. These compounds can inhibit NADPH oxidase, and have a better anti-oxidation and anti-inflammatory dual pharmacological mechanism than berberine. Some of these compounds can also provide NO, H 2 The donor group of S can further enhance the pharmacological activity, and it is a new class of multifunctional compound. The disclosed JJA-D0 derivatives can be used to prevent or treat diseases related to NADPH oxidase, diseases related to free radicals, diseases related to inflammation, diseases related to NO, diseases related to H 2 Preparation of health products or medicines for S-related diseases.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the field of medicine, and in particular relates to derivatives of berberine dimer analog JJA-D0 or pharmaceutically acceptable salts thereof, preparation methods and applications. Background technique

[0002] Berberine is the main active ingredient in Hu Huanglian, a commonly used traditional Chinese medicine. It was originally isolated from Apocynum Cannabinum L., and its structure is shown below. Huhuanglian is the rhizome of Tibet Huhuanglian and Huhuanglian, which are plants of the family Scrophulariaceae. Huhuanglian is mainly distributed in the Himalayas, and Tibetan Huhuanglian is mainly distributed in Sichuan, Yunnan, and Tibet.

[0003]

[0004] Molecular structure of berberine

[0005] Huhuanglian is used in Indian folk for the treatment of gallbladder, antimalarial, spleen, urinary tract infection and hepatitis. With the in-depth study of its chemical components and pharmacological effects, it was found that ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More