A kind of berberine anti-tumor platinum (ii) complex and its synthesis method and application

An anti-tumor drug, anti-tumor technology, applied in the direction of anti-tumor drugs, platinum-based organic compounds, platinum-based organic compounds, etc., to achieve the effects of mild reaction conditions, targeted inhibition of proliferation, and high yield
CN110105402BActive Publication Date: 2021-09-07YULIN NORMAL UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
YULIN NORMAL UNIVERSITY
Publication Date
2021-09-07

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Abstract

The invention relates to a berberine anti-tumor platinum (II) complex, its synthesis method and the application of the complex in the preparation of anti-tumor drugs. The synthesis method of the berberine anti-tumor platinum (II) complex comprises the following steps: (1) dissolving the brominated berberine derivative, potassium halide and lutidine amine in a solvent, and reacting at 90° C. to obtain B ‑TFA ligand; (2) the B‑TFA ligand prepared in step (1) and dichlorobis(dimethylsulfoxide) platinum (II) are dissolved in acetonitrile solution, and carry out coordination reaction 4~6 Hours, the product was washed and dried to obtain. The present invention uses the brominated berberine derivative B-TFA as the active ligand for the first time to synthesize its platinum complex, which exhibits superior anti-tumor activity and targeting in vivo and in vitro, has potential medicinal value, and is expected to be used in various Preparation of antineoplastic drugs. The structural formula of the berberine anti-tumor platinum (II) complex is as follows:
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Description

Technical field

[0001] The present invention relates to a high active platinum complexes, and synthetic methods, in particular to a berberine antitumor platinum (II) complexes and their synthesis. The present invention further relates to berberine antitumor platinum (II) was prepared with the application of anti-tumor drugs. Background technique

[0002] Since cisplatin is found, there have been Nida, oxaliplatin, Shu platinum and platinum music four anti-cancer drugs on the market to use, but still unsatisfactory in improving the efficacy, reduced toxicity and overcome terms of cross-resistance . Scientists and researchers to platinum by various structural modifications, trying to synthesize a new class of anti-tumor platinum complexes, hoping to find more active, less toxic platinum anti-cancer drugs by such an attempt.

[0003] The main chemical composition of yellow vine yellow vine alkaloids, mainly located in the region of Guangxi, Yunnan and Guangdong, which is one of the ...

Claims

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