Anti- P.aeruginosa pharmaceutical composition as well as preparation method and application thereof

A technology of Pseudomonas aeruginosa and composition, applied in antibacterial drugs, pharmaceutical formulations, medical preparations containing active ingredients, etc., to achieve the effect of improving antibacterial effect, low price, and good biocompatibility
CN112294807AInactive Publication Date: 2021-02-02TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
Publication Date
2021-02-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides an anti- P.aeruginosa pharmaceutical composition as well as a preparation method and application thereof. The pharmaceutical composition comprises the following components: (1)berberine and / or halogenated berberine, and (2) 3, 4-dibromomaleimide. Compared with single use of the berberine or the halogenated berberine for resisting P.aeruginosa, the anti- P.aeruginosa pharmaceutical composition has the advantages that after the berberine, the halogenated berberine and the 3, 4-dibromomaleimide adjuvant are compatible, the anti- P.aeruginosa activity of the pharmaceuticalcomposition can be improved by 4 times or above compared with that of raw medicines (the berberine and the halogenated berberine). Due to the fact that the dosage of raw medicines is greatly reduced,the content of the medicines of the berberine and the halogenated berberine contained in the novel preparation can be reduced by 4 times or above compared with the concentration of the raw medicines,and toxicity and various adverse reactions caused by high-dosage medication of various berberine and halogenated berberine are effectively avoided.
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Description

technical field

[0001] The invention belongs to the field of anti-Pseudomonas aeruginosa, in particular to an anti-Pseudomonas aeruginosa pharmaceutical composition and its preparation method and application. Background technique

[0002] Pseudomonas aeruginosa, or P. aeruginosa for short, is a ubiquitous Gram-negative pathogenic bacterium that causes high morbidity in cystic fibrosis patients and immunocompromised patients and mortality. Pseudomonas aeruginosa is considered an opportunistic pathogen, the most common bacterium in nosocomial infections, and its sources are very diverse, including cystic fibrosis, burns, urinary tract infections, and lung infections bacteria. Pseudomonas aeruginosa has low pathogenicity but strong resistance to most antibiotics including aminoglycosides, quinolones and β-lactams. The mechanisms of drug resistance are diverse, including the production of antibiotic inactivating enzymes, inhibition of drug penetration through the cell wall, r...

Claims

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