Silver ion no-clean disinfectant as well as preparation method and application thereof

A technology of disinfectant and silver ions, applied in the field of sanitary cleaning products, can solve the problems of insufficient sterilization ability, inability to kill multiple bacteria and viruses, skin irritation, etc., and achieve good product stability, resistance to drug resistance, and preparation The effect of the simple method

Pending Publication Date: 2022-05-24
HUNAN ANSON MEDICAL POLYMER MATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the chemical type of disposable disinfectant contains a large amount of chemical raw materials, which are irritating to the skin; the traditional Chinese medicine type of disposable disinfectant generally has insufficient bactericidal ability and cannot meet the sterilization of multiple bacteria and viruses

Method used

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  • Silver ion no-clean disinfectant as well as preparation method and application thereof
  • Silver ion no-clean disinfectant as well as preparation method and application thereof
  • Silver ion no-clean disinfectant as well as preparation method and application thereof

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preparation example Construction

[0061] Another aspect of the present invention provides a preparation method of a silver ion no-clean disinfectant for preparing the above-mentioned silver ion no-clean disinfectant, the method comprising the following steps:

[0062] Provide each raw material according to the proportion of components;

[0063] The raw materials are mixed uniformly.

[0064] Specifically, the preparation method of silver ion disposable disinfectant comprises the following steps:

[0065] S1. Provide each raw material component.

[0066] S2, dissolve the thickener in deionized water to obtain a thickener solution of 2wt% to 5wt%, add the pH regulator according to the mass ratio of thickener:pH regulator=(1~2):1, and mix evenly , wrap the beaker with tin foil, and place it in a cool place at room temperature to swell for 10h to 12h.

[0067] S3. Mix ethanol, silver nitrate, Coptis chinensis extract, stabilizer and humectant to obtain a premixed solution, add it to the swollen thickener soluti...

Embodiment 1

[0081] 1. Preparation of Coptis chinensis extract

[0082] The rhizomes of Coptidis chinensis are air-dried, chopped into pieces of 1 cm to 2 cm and crushed to obtain Coptis chinensis pretreatment powder. Weigh 10 g of Coptis chinensis pretreatment powder and mix it with 100 mL of 95% ethanol, wrap the mouth of the beaker with silver foil, put it in an ultrasonic machine, and ultrasonicate for 3 hours. Solid Coptis chinensis and dregs are obtained to obtain an extract after extraction, and the solvent is removed to about 12mL by distillation to obtain Coptis chinensis extract, and finally the berberine content is measured by high performance liquid chromatography to be 25mg / mL.

[0083] 2. Preparation of Carbomer Gel

[0084] Weigh 1 g of carbomer, dissolve it in 50 mL of deionized water to obtain a 2% carbomer solution, add 0.5 g of triethanolamine, mix well, wrap the beaker with tin foil, and swell in a cool place at room temperature for 12 hours.

[0085] 3. Preparation o...

Embodiment 2

[0096] 1. Preparation of Coptis chinensis extract

[0097] The rhizomes of Coptidis chinensis are air-dried, chopped into 1cm-2cm pieces and crushed to obtain Coptis chinensis pretreatment powder. Weigh 10 g of Coptis chinensis pretreatment powder and mix it with 100 mL of 95% ethanol, wrap the mouth of the beaker with silver foil, put it into the ultrasonic tank, and ultrasonicate for 2 hours, 30 minutes each time, divided into four times. The suction filtration device performs suction filtration on the solvent to remove the solid coptis and dregs to obtain the extracted extract, and the solvent is removed to about 8 mL by distillation to obtain the coptis extract, and finally the berberine content is measured by high performance liquid chromatography. is 50 mg / mL.

[0098] 2. Carbomer gel preparation process:

[0099] Weigh 1 g of carbomer, dissolve it in 50 mL of deionized water to obtain a 2% carbomer solution, add 0.5 g of triethanolamine, mix well, wrap the beaker with...

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Abstract

The invention provides a silver ion no-wash disinfectant as well as a preparation method and application thereof. The silver ion no-wash disinfectant is prepared from the following raw materials in percentage by weight: 50 to 70 percent of absolute ethyl alcohol, 0.001 to 0.05 percent of silver nitrate, 1 to 10 percent of rhizoma coptidis extracting solution, 0.5 to 5 percent of stabilizer, 0.01 to 1 percent of pH regulator, 0.1 to 2 percent of thickener, 1 to 5 percent of humectant and the balance of water, wherein the coptis chinensis extract contains berberine, and the concentration of the berberine in the washing-free disinfectant is 0.1 mg/mL to 1 mg/mL. The no-clean disinfectant disclosed by the invention has the advantages of safety, good sterilization and bacteriostasis effects, difficulty in generating drug resistance and the like.

Description

technical field [0001] The invention relates to the technical field of sanitary cleaning products, in particular to a silver ion no-clean disinfectant and a preparation method and application thereof. Background technique [0002] In human history, silver has been widely used for thousands of years because of its excellent antibacterial effect. Using silverware to preserve food can slow down the speed of food spoilage. Using silver ion dressing to treat wounds can effectively promote wound healing. The sterilization mechanism of silver ions mainly includes the following aspects: (1) damage bacterial DNA: silver ions can interact with bacterial DNA after entering the bacteria, resulting in DNA denaturation, thereby inhibiting DNA replication and transcription; (2) inactivating proteins : Silver ions can bind to the negatively charged peptidoglycan on the cell wall and attach to the sulfur-containing protein of the cell membrane, causing protein inactivation, leading to the lo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/19A61K8/9789A61K8/34A61Q19/10A61Q17/00
CPCA61K8/19A61K8/9789A61K8/34A61Q19/10A61Q17/005Y02A50/30
Inventor 郑丛龙许恒毅郭四姣
Owner HUNAN ANSON MEDICAL POLYMER MATERIALS
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