Purification method of berberine or its hydrochloride

Abstract

The invention discloses a method for purifying berberine or its hydrochloride, which comprises: mainly including the reaction of the starting material mainly containing berberine, berberine hydrochloride or berberine sulfate with salt II, and converting it into an intermediate salt of berberine, Finally, the intermediate salt of berberine is converted into berberine or its hydrochloride. The present invention converts the starting material mainly containing berberine, berberine hydrochloride or berberine sulfate into an intermediate salt of berberine, removes impurities, and then converts the intermediate salt of berberine into berberine or its hydrochloride, The final product has a total impurity content of less than 0.2% and a single impurity content of less than 0.1%, which further ensures the safety of the drug.

Description

technical field

[0001] The invention belongs to the technical field of organic synthesis, in particular to a method for purifying berberine or its hydrochloride. Background technique

[0002] Berberine is an important alkaloid, which has been used in traditional Chinese medicine for a long time in our country. It can be extracted from plants such as Coptis chinensis, Cortex Phellodendri, and three needles. It has a significant antibacterial effect. Commonly used berberine hydrochloride is also called berberine hydrochloride, and its chemical structure is shown in formula I, and berberine can also exist in the form of sulfate. Berberine can resist pathogenic microorganisms, and has inhibitory effects on a variety of bacteria such as Shigella, Mycobacterium tuberculosis, Pneumococcus, Salmonella typhi and Diphtheria bacillus. Among them, it has the strongest effect on Shigella, and is often used to treat bacillary gastroenteritis and dysentery. and other gastrointestinal di...

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