Pharmaceutical composition for treatment of inflammatory skin diseases, preparation method and use thereof

A technology for inflammatory skin diseases and compositions, applied in the field of medicines or health products, can solve problems such as contraindications, toxic side effects, etc.

Inactive Publication Date: 2018-01-26
ZHANGZHOU PIEN TZE HUANG PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Western medicine for acne is mainly aimed at the etiology of oral and topical antibiotics, estrogen, and retinoic acid preparations. Although the above treatments have certain curative effects, there are many problems such as contraindications and side effects

Method used

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  • Pharmaceutical composition for treatment of inflammatory skin diseases, preparation method and use thereof
  • Pharmaceutical composition for treatment of inflammatory skin diseases, preparation method and use thereof
  • Pharmaceutical composition for treatment of inflammatory skin diseases, preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0101] The raw material drug composition of the pharmaceutical composition of this embodiment is: Pien Tze Huang 10g, Baifengcai 80g, Nobiletin 6g, Berberine 4g.

[0102] The preparation method of this pharmaceutical composition is:

[0103] Take Pien Tze Huang of selected weight, pulverize it, add 10 times by weight of ethanol aqueous solution with a volume concentration of 70%, and immerse and extract at room temperature for at least 12 hours, stir for 3 hours, filter, and combine the filtrates to obtain extract A and medicinal residues; Add 6 times the weight of water to the slag and boil it slightly for 1 hour, filter to obtain extract B, combine extract A and extract B, concentrate under reduced pressure until there is no alcohol smell, and obtain Pien Tze Huang extract;

[0104] Get the selected weight of Baifengcai, pulverize, add 30 times by weight of water to extract, adjust the pH value of the extract to 5 with dilute hydrochloric acid, and obtain a reaction solution...

Embodiment 2

[0123] The raw materials of the pharmaceutical composition of this embodiment consist of: Pien Tze Huang 9g, Baifengcai 88g, Nobiletin 5.4g, and Berberine 4.4g.

[0124] The preparation method of the pharmaceutical composition is as follows: take a selected weight of Pien Tze Huang, pulverize it, add 5 times by weight of an aqueous ethanol solution with a volume concentration of 90%, soak and extract at room temperature for at least 12 hours, stir for 3 hours, filter, and combine the filtrates to obtain an extract A and medicinal dregs: take the medicinal dregs and add 3 times the weight of water to extract by boiling for 1.5h, filter to obtain extract B, combine extract A and extract B, concentrate under reduced pressure until there is no alcohol smell, and obtain Pien Tze Huang extract liquid;

[0125] Get the selected weight of Baifengcai, pulverize, add 10 times the amount of water for extraction, adjust the pH value of the extract to 8 with dilute sodium hydroxide solutio...

Embodiment 3

[0130] The raw materials of the pharmaceutical composition in this embodiment consist of: Pien Tze Huang 11g, Baifengcai 72g, Nobiletin 6.6g, and Berberine 3.6g.

[0131] The preparation method of this pharmaceutical composition is:

[0132] Take Pien Tze Huang of selected weight, pulverize it, add 15 times by weight of an ethanol aqueous solution with a volume concentration of 50%, and immerse and extract at room temperature for at least 12 hours, stir for 3 hours, filter, and combine the filtrates to obtain extract A and medicinal residues; Add 9 times the weight of water to the slag and boil for 0.5h, filter to obtain extract B, combine extract A and extract B, concentrate under reduced pressure until there is no alcohol smell, and obtain Pien Tze Huang extract;

[0133] Get the selected weight of Baifengcai, pulverize, add 50 times by weight of water to extract, adjust the pH value of the extract to 4 with dilute hydrochloric acid, and obtain a reaction solution; then add ...

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Abstract

Belonging to the field of drugs or health care products, the invention relates to a pharmaceutical composition for treatment of inflammatory skin diseases, in particular to a pharmaceutical composition for treatment of acnes. The pharmaceutical composition comprises the following raw materials: 8.5-11.5 parts by weight of Chinese herb Pien Tze Huang, 68-92 parts by weight of Gynura formosana, 5.1-6.9 parts by weight of hesperidin, and 3.4-4.6 parts by weight of berberine. Clinical research shows that the pharmaceutical composition not only has obvious therapeutic effect on acnes, has a clinical total effective rate up to 90%, but also can effectively improve pigmentation and scars left after acne fading, and has little adverse reaction in clinical application and high safety, thus having good clinical application prospect.

Description

technical field [0001] The invention belongs to the field of medicines or health care products, and relates to a pharmaceutical composition for treating inflammatory skin diseases and its preparation method and application, in particular to a pharmaceutical composition for treating acne, its preparation method and application. Background technique [0002] Acne is a common inflammatory skin disease, which mainly occurs on the face, chest and back of young men and women. The affected parts mainly manifest as acne, papules, pustules, cysts, nodules, hyperplasia and atrophic scars and other skin lesions. Affects the patient's facial appearance. The pathogenesis of acne is closely related to multiple factors such as blockage of the pilosebaceous gland duct, excessive sebum secretion, and bacterial infection. Factors such as eating habits also have an impact on acne, which can aggravate the condition to a certain extent. In recent years, with the acceleration of people's life r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61K9/06A61K47/36A61K47/10A61P17/10A61P17/00A61P31/04A61P31/02A61K8/9789A61K8/98A61K8/60A61K8/49A61Q19/00A61Q17/00A61K35/55A61K35/413A61K35/583A61K31/7048A61K31/4375
Inventor 袁慧君殷婷婷于娟洪绯曾金香郑玉清
Owner ZHANGZHOU PIEN TZE HUANG PHARM
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