A traditional Chinese medicine compound preparation for treating non-alcoholic fatty liver disease and its preparation method

Abstract

The invention discloses a traditional Chinese medicine compound preparation for treating nonalcoholic fatty liver disease and a preparation method thereof. The compound preparation is prepared from the following raw medicinal materials in parts by weight: 500-1500 parts of rhizoma alismatis, 500-1500 parts of hawthorn, 250-750 parts of cattail pollen, 330-1000 parts of folium nelumbinis and 85-250 parts of pseudo-ginseng. In the compound preparation, the sweet and fresh rhizoma alismatis is selected as a monarch drug and has the effects of purging water-dampness of the bladder meridian, promoting diuresis and dispelling turbidity; hawthorn with the effects of strengthening spleen, promoting appetite, promoting digestion to eliminate stagnation, activating blood circulation and removing phlegm is used as a ministerial drug; folium nelumbinis and cattail pollen are used as adjuvant drugs, wherein folium nelumbinis is bitter and mild and acts on liver and is capable of promoting diuresis and invigorating splenic yang, and cattail pollen acts on blood and is capable of running up and down to reach everywhere of a body, activating stagnation, removing blood stasis, promoting qi circulation and stimulating menstrual flow; pseudo-ginseng is used as a conductant drug and has the effects of activating blood circulation to remove stasis, diminishing swelling and relieving pain; and all the components work together to play effects of promoting diuresis, removing phlegm, and activating blood circulation to remove stasis. The traditional Chinese medicine compound preparation is capable of effectively improving lipid metabolism disorders of a nonalcoholic fatty liver animal model, reducing insulin resistance and relieving oxidative stress injury. Years of clinical practices indicate that the traditional Chinese medicine compound preparation has an exact curative effect of improving the serum biochemical index, recovering normal body weight and fatty liver and the like for patients with NAFLD (nonalcoholic fatty liver disease).

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a compound traditional Chinese medicine preparation for treating nonalcoholic fatty liver disease and a preparation method thereof. Background technique [0002] Normal people have about 4-5g of lipids per 100g of liver wet weight, of which phospholipids account for more than 50%, triglycerides (TG) account for 20%, free fatty acids account for 20%, cholesterol is about 7%, and the rest is cholesterol esters. When the lipid accumulation in the liver cells exceeds 5% of the wet weight of the liver, or when more than 1 / 3 of the hepatic cells are observed to be fatty per unit area in histology, it is called fatty liver. Clinically, it is often divided into alcoholic and non-alcoholic according to whether drinking or not. Nonalcoholic fatty liver disease (NAFLD), first proposed by Ludwing in 1980, is a clinicopathological syndrome characterized by steatosis a...

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Problems solved by technology

[0003] At present, the treatment measures for NAFLD are mainly divided into three categories: ① weight control, the disadvantage is that it is difficult to persist, and the progress of the disease cannot be completely controlled; ② drug treatment, the disadvantage is that most alternative drugs such as thiazolidinediones and lipid-lowering drugs cannot Effectively alleviate the inflammatory lesions of the liver histology, and the toxic and side effects are large, and most of them have hepatotoxicity; ③The disadvantage of liver transplantation is that it is expensive and has a high recurrence rate

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