Pharmaceutical composition for treating tuberculosis and preparation method thereof

A composition and technology for tuberculosis, applied in the directions of pharmaceutical formulations, medical preparations containing active ingredients, antibacterial drugs, etc., can solve the problems of drug resistance, insignificant treatment effect, long curative effect, etc. Infection spread and effect of raising thymus mass index

Inactive Publication Date: 2014-12-10
强红枫
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no obvious breakthrough in the research of anti-tuberculosis drugs at home and abroad, and western medicines are still used repeatedly. The number of drug resistance and multi-drug resistance increases exponentially every year. Important task of prevention and control
Traditional Chinese medicine has been used to treat tuberculosis for thousands of years, but the existing traditional Chinese medicines for treating tuberculosis have defects such as long curative effect, inconspicuous therapeutic effect and easy drug resistance.

Method used

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  • Pharmaceutical composition for treating tuberculosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The preparation of embodiment 1 Chinese medicine extract

[0022] (1) Weigh astragalus 0.24kg, Codonopsis 0.12kg, Atractylodes macrocephala 0.24kg, Chinese yam 0.15kg, Magnolia officinalis 0.09kg, Atractylodes 0.07kg, Deer jelly 0.12kg, Xiaoheiyao 0.12kg, Poria cocos 0.24kg, comfrey 0.24kg, red peony 0.10kg, Baiwei 0.09kg, medlar 0.11kg, schisandra 0.15kg, arborvitae leaves 0.09kg, sealwort 0.18kg, black sun ginseng 0.09kg, notoginseng 0.10kg, madder 0.10kg, copper hammer jade belt Grass 0.10kg, Habitat 0.24kg, Ophiopogon japonicus 0.24kg, Lily 0.12kg, Campanulaceae 0.12kg, Scrophulariaceae 0.12kg, Digupi 0.09kg, Turtle shell 0.07kg, Artemisia annua 0.18kg, Bitter almond 0.18kg, Aster 0.18kg , Shiwei 0.12kg, loquat leaf 0.12kg, coltsfoot flower 0.12kg, tinglizi 0.09kg, coir coir lotus 0.09kg, earthworm 0.09kg, black plum 0.09kg, purple river car 0.09kg, spare;

[0023] (2) Take the turtle shell and Ziheche, mix them, add water and cook for 1.5 hours, adjust the pH valu...

Embodiment 2

[0025] Therapeutic Experimental Research of Example 2 Chinese Medicine Extract on Tuberculosis Mouse Model

[0026] Twenty-four 8-week-old Kunming mice weighed 18-22 g, half male and half male. Select human-type Mycobacterium tuberculosis H37Rv standard strain to infect mice, the specific method is to take 0.4mL containing 6.6×10 5 The CFU suspension of Mycobacterium tuberculosis H37Rv was injected into the tail vein of mice to establish a mouse model of tuberculosis. The model mice were randomly divided into the following two groups: model control group and traditional Chinese medicine treatment group, with 12 mice in each group, half male and half male. From the second day after the mice were infected with Mycobacterium tuberculosis H37Rv, the mice in the traditional Chinese medicine treatment group were treated with 53.6 mg / kg / d of the traditional Chinese medicine extract prepared in Example 1 for 3 months on the basis of their body weight, once a day ; The model control ...

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Abstract

The invention discloses a pharmaceutical composition for treating the tuberculosis and a preparation method thereof. The pharmaceutical composition comprises active ingredients and pharmaceutically acceptable auxiliary materials. The active ingredients are prepared from the following Chinese herbal medicine raw materials: astragalus mongholicus, codonopsis pilosula, bighead atractylodes rhizome, Chinese yam, mangnolia officinalis, rhizoma atractylodis, balanophora laxiflora hemsl, root of Szechwan-Yunnan sanicle, poria cocos, alkanna tinctoria, radix paeoniae rubra, cynanchum atratum, the fruit of Chinese wolfberry, the fruit of Chinese magnoliavine, cacumen biotae, rhizoma polygonati, root of dunn antictrema, pseudo-ginseng, madder, common pratia herb,rhizome of rehmannia,lilyturf root, lily, platycodon grandiflorum, radix scrophulariae, cortex lycii radicis, turtle shell, sweet wormwood, semen armeniacae amarae, aster, pyrrosia lingua, folium eriobotryae, flos farfarae, semen lepidii, auriculateleaf aster, earthworm, smoked plum and placenta hominis. The pharmaceutical composition has the effects of tonifying the spleen and kidney, activating blood and dissolving stasis, nourishing yin for lowering fire and moistening lung to arrest cough, has an exact curative effect, has no toxic or side effects, is simple, convenient and practical and is easy to accept by a patient.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating tuberculosis and a preparation method thereof. Background technique [0002] According to WHO statistics, there are 9.27 million tuberculosis patients in the world. China is one of the 22 countries with a high burden of tuberculosis in the world. The number of tuberculosis patients ranks second in the world and 130,000 people die every year. At present, there is no obvious breakthrough in the research of anti-tuberculosis drugs at home and abroad, and western medicines are still used repeatedly. The number of drug resistance and multi-drug resistance increases exponentially every year. important task of prevention. The medical treatment of pulmonary tuberculosis in the motherland has a history of thousands of years, but the existing traditional Chinese medicines for the treatment of tubercul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61P31/06
Inventor 段懿玲
Owner 强红枫
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