Preparation method of three-dimensional radiochromic gel dosimeter

A gel dosimeter and radiochromic technology, which is applied in the application fields of polymer radiation chemistry and nuclear technology, can solve the problems of inability to accurately measure three-dimensional dose distribution, poor diffusion effect molding ability, etc., and achieves good dose response linearity and simple preparation. , the effect of overcoming the diffusion effect

Inactive Publication Date: 2014-12-10
SICHUAN UNIV
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the embodiment of the present invention is to provide a preparation method of a three-dimensional radiochromic gel dosimeter, which aims to solve the defici

Method used

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  • Preparation method of three-dimensional radiochromic gel dosimeter
  • Preparation method of three-dimensional radiochromic gel dosimeter
  • Preparation method of three-dimensional radiochromic gel dosimeter

Examples

Experimental program
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Example Embodiment

[0028] Such as figure 1 As shown, the preparation method of the three-dimensional radiochromic gel dosimeter of the embodiment of the present invention includes the following steps:

[0029] S101: Preparation of diacetylene compound nanovesicles by injection method or thin film method;

[0030] S102: Preparation of radiochromic gel dosimeter by chemical cross-linking method, refreezing method or condensation method.

[0031] In step S101, the preparation method of diacetylene compound nanovesicles includes:

[0032] Preparation of diacetylene compound nanovesicles by injection method or thin film method;

[0033] Injection method: Dissolve diacetylene compounds in an organic solvent to prepare a 0.3% to 2% solution, and inject the above solution into deionized water with a temperature higher than the boiling point of the organic solvent at a volume ratio of 1:4 to 1:50 at a high temperature Ultrasound in a water bath, put it in a refrigerator at 4°C for more than 6 hours after standing...

Example Embodiment

[0059] Example 1:

[0060] Dissolve 80mg of 10,12-pentadecadiynoic acid in 10ml of acetone to form a solution, pour the above solution into 80ml of deionized water at a temperature of 70℃ and keep the temperature in a water bath for ultrasound, let it stand to room temperature and put it in a refrigerator at 4℃ for storage Get 10,12-pentadecadiynoic acid nanovesicle solution in more than 6 hours;

[0061] Add 12g of acrylamide, 0.8g of N,N-methylenebisacrylamide and 0.8g of glucose into 80ml of 10,12-pentadecadiynoic acid vesicle solution. After ultrasonic dissolving, heat to 50~60℃ in a water bath, and add 12ml The ammonium sulfate aqueous solution (concentration 0.01g / ml) is stirred and mixed uniformly, and the temperature is maintained until the polymerization and crosslinking of the acrylamide monomer is completed to form a high-sensitivity radiochromic gel dosimeter.

Example Embodiment

[0062] Example 2:

[0063] Dissolve 80 mg of 10,12-trichosadiynoic acid in 10 ml of ethanol to form a solution. Add the above solution to a round-bottom flask. After the solvent is evaporated by rotary evaporation, a uniform transparent film is formed on the bottom of the flask. Add 40ml of deionized water to the flask and obtain a transparent or translucent emulsion after high temperature (80℃) water bath ultrasound. After cooling to room temperature, place the solution in the refrigerator at 4℃ for more than 6 hours to obtain 10,12- Twenty-three carbodiynoic acid nanovesicle solution;

[0064] Add 3.2g of agarose into 40ml of water and heat it to above 90℃ to completely dissolve the agarose. Mix the agarose aqueous solution and the diacetylene vesicle solution evenly in a volume ratio of 1:1, and cool to room temperature to allow the gel to solidify and form a high Sensitivity radiochromic gel dosimeter.

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Abstract

The invention discloses a preparation method of a three-dimensional radiochromic gel dosimeter. The preparation method has the following steps: comprising a radiochromic system and a tissue equivalent gel carrier system; using a vesicle made from diacetylene compounds as the radiochromic system; preparing a gel carrier with tissue equivalent organic polymer materials; and preparing the nanometer vesicle made from the diacetylene compounds by adopting an injection method or a thin film method, and preparing the radiochromic gel dosimeter by adopting a chemical crosslinking method, a repetitive freezing method or a condensation method. Each infinitesimal substance of the gel can have relevant color changes according to different adsorbed doses, and the general three-dimensional dose distribution can be judged in a visual manner. After the doses of the gel are calibrated, the three-dimensional dose distribution can be determined by scanning and measuring the absorbance. The preparation method effectively overcomes the problems of diffusing effect, radiation late effect and low forming ability for the existing gel dosimeter, and exactly measures the three-dimensional dose distribution of a dose field with a steep dose distribution. The preparation method has the advantages of simple preparation, convenient analysis, high sensitivity and stable performance, and is available for popularization and usage.

Description

technical field [0001] The invention belongs to the application field of polymer radiation chemistry and nuclear technology, and in particular relates to a preparation method of a three-dimensional radiochromic gel dosimeter. Background technique [0002] The gel dosimeter uses the gel medium as the carrier of spatial dose information to evenly distribute radiation-sensitive compounds. When receiving ionizing radiation, the compounds undergo radiation chemical reactions, and the chemical yield of the products is a function of the absorbed dose. The absorbed dose can be recovered by measuring the chemical yield of the product or the change in the physicochemical properties of the gel caused by the product. Compared with other conventional dosimeters, the gel dosimeter can measure the dose at any point in the target area at one time, not just the surface dose or the dose at a certain point. The gel dosimeter has high spatial resolution, dose accuracy and tissue equivalence, a...

Claims

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Application Information

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IPC IPC(8): G01T1/04C08F220/56C08F222/38C08J3/24
Inventor 蒋波孙鹏傅玉川黄玮胡娟郝娜
Owner SICHUAN UNIV
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