Preparation method of a three-dimensional radiochromic gel dosimeter

A gel dosimeter and radiochromic technology, applied in the application fields of polymer radiation chemistry and nuclear technology, can solve the problems of poor diffusion effect molding ability, inability to accurately measure three-dimensional dose distribution, etc., and achieve good dose response linearity and simple preparation. , the effect of broad application prospects

Inactive Publication Date: 2017-06-13
SICHUAN UNIV
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Problems solved by technology

[0004] The purpose of the embodiment of the present invention is to provide a preparation method of a three-dimensional radiochromic gel dosimeter, which aims to solve the deficiencies of the existing gel dosimeters such as diffusion effect, radiation aftereffect, poor molding ability, etc. Steep Dose Distribution Dose Field 3D Dose Distribution Problem

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  • Preparation method of a three-dimensional radiochromic gel dosimeter

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preparation example Construction

[0028] Such as figure 1 As shown, the preparation method of the three-dimensional radiochromic gel dosimeter of the embodiment of the present invention comprises the following steps:

[0029] S101: Prepare diacetylene compound nanovesicles by injection method or film method;

[0030] S102: Prepare the radiochromic gel dosimeter by chemical cross-linking method, refreezing method or condensation method.

[0031] In step S101, the preparation method of diacetylene compound nanovesicles includes:

[0032] Preparation of diacetylene compound nanovesicles by injection method or film method;

[0033] Injection method: Dissolve diacetylene compounds in organic solvents to prepare a 0.3% to 2% solution, inject the above solution into deionized water with a temperature higher than the boiling point of the organic solvent at a volume ratio of 1:4 to 1:50 and heat Ultrasound in a water bath, let it stand at room temperature, and put it in a refrigerator at 4°C for more than 6 hours to...

Embodiment 1

[0060] Dissolve 80mg of 10,12-pentacosadiynoic acid in 10ml of acetone to form a solution. Pour the above solution into 80ml of deionized water at a temperature of 70°C and keep the temperature in a water bath for ultrasonication. After standing at room temperature, put it in a refrigerator at 4°C. Obtain 10,12-pentacosadiynoic acid nanovesicle solution for more than 6 hours;

[0061] Add 12g of acrylamide, 0.8g of N,N-methylenebisacrylamide and 0.8g of glucose into 80ml of 10,12-pentacosadiynoic acid vesicle solution. Aqueous ammonium sulfate solution (concentration 0.01g / ml) was stirred and mixed evenly, and the temperature was kept until the polymerization and crosslinking of acrylamide monomers were completed to form a high-sensitivity radiochromic gel dosimeter.

Embodiment 2

[0063] Dissolve 80mg of 10,12-tracosadiynoic acid in 10ml of ethanol to form a solution, add the above solution into a round bottom flask, evaporate the solvent to dryness by rotary evaporation, and form a uniform transparent film at the bottom of the flask. Add 40ml of deionized water to the flask, and obtain a transparent or translucent emulsion after ultrasonication in a high-temperature (80°C) water bath. After cooling to room temperature, place the solution in a refrigerator at 4°C for more than 6 hours to obtain 10,12- Tricosadiynoic acid nanovesicle solution;

[0064] Add 3.2g of agarose to 40ml of water and heat to above 90°C to completely dissolve the agarose, mix the agarose aqueous solution and diacetylene compound vesicle solution at a volume ratio of 1:1, cool to room temperature and let the gel solidify to form a high Sensitivity radiochromic gel dosimeter.

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Abstract

The invention discloses a preparation method of a three-dimensional radiochromic gel dosimeter, a radiochromic system and a tissue-equivalent gel carrier system, vesicles made of diacetylene compounds are used as the radiochromic system, and the gel carrier is composed of tissue Prepared from equivalent organic polymer materials; including preparation of diacetylene compound nanovesicles by injection method or film method and preparation of radiochromic gel dosimeter by chemical crosslinking method, refreezing method or condensation method. Each microelement of the gel of the present invention will have corresponding color changes with different absorbed doses, and the approximate three-dimensional dose distribution can be judged visually; after the dose calibration of the gel, the three-dimensional dose distribution can be determined by scanning and measuring its absorbance; It effectively overcomes the problems of diffusion effect, after-radiation effect, and poor forming ability of existing gel dosimeters, and accurately measures the three-dimensional dose distribution of the dose field with a steep dose distribution; it is simple to prepare, convenient to analyze, high in sensitivity, and stable in performance, which is beneficial to Promotional use.

Description

technical field [0001] The invention belongs to the application field of polymer radiation chemistry and nuclear technology, and in particular relates to a preparation method of a three-dimensional radiochromic gel dosimeter. Background technique [0002] The gel dosimeter uses the gel medium as the carrier of spatial dose information to evenly distribute radiation-sensitive compounds. When receiving ionizing radiation, the compounds undergo radiation chemical reactions, and the chemical yield of the products is a function of the absorbed dose. The absorbed dose can be recovered by measuring the chemical yield of the product or the change in the physicochemical properties of the gel caused by the product. Compared with other conventional dosimeters, the gel dosimeter can measure the dose at any point in the target area at one time, not just the surface dose or the dose at a certain point. The gel dosimeter has high spatial resolution, dose accuracy and tissue equivalence, a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01T1/04C08F220/56C08F222/38C08J3/24
Inventor 蒋波孙鹏傅玉川黄玮胡娟郝娜
Owner SICHUAN UNIV
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