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Method for rapid detection of promazine substances in product

A product, the technology of promethazine, applied in the preparation of test samples, electrochemical variables of materials, etc., can solve the problems of interfering with the conductivity of the sample solution, the total dissolved solids, the technical difficulties of promethazine substances, and the unsatisfactory effect.

Active Publication Date: 2014-12-17
BEIJING INST FOR DRUG CONTROL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Then, is it possible to directly use the electrochemical method of detecting the conductivity or total dissolved solids in water to detect the central nervous system depressant drugs, health products or foods suspected of adding promethazine substances? It was found that the effect was not ideal, because the complex matrix of central nervous system depressant drugs, health care products or food that may be added with promethazines contains other hydrophilic substances, which will seriously interfere with the conductivity of the sample solution and in the solution. Total Dissolved Solids (TDS) of the total dissolved solids (TDS), resulting in no correlation between the results and the addition of promethazines
Therefore, it is technically difficult to directly use the electrochemical method of detecting the conductivity or total dissolved solids in the solution to detect whether the central nervous system depressant drugs, health products or food are illegally added with promethazines.

Method used

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  • Method for rapid detection of promazine substances in product
  • Method for rapid detection of promazine substances in product
  • Method for rapid detection of promazine substances in product

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1, detect the general operating conditions of whether promethazines are contained in medicines / health care products

[0061] 1. Sampling volume:

[0062] Sampling recommendations for different types of samples are as follows:

[0063] sample type

Sampling volume

tablet

One oral dose (need to be crushed)

Capsules

Oral dose at one time (take the contents and grind them)

big honey pill

One-time oral dose (need to be crushed)

Granules

One-time oral dose (need to be crushed)

other solid

oral dose

[0064] This shows that the amount of the product to be inspected that the inventive method uses is few, so that the interests of innocent operators are damaged as little as possible, the dosage of the above various types of samples is about 0.5~5g at a time, such as capsules and tablets at a time of about 0.5-5g. 0.5g, while the dosage of granules and big honeyed pills is about 5g at a time.

...

Embodiment 2

[0070] Embodiment 2, detect the general operating conditions of whether promethazines are contained in medicines / health care products

[0071] 1. Sampling volume:

[0072] Sampling recommendations for different types of samples are as follows:

[0073] sample type

Sampling volume

tablet

One oral dose (need to be crushed)

Capsules

Oral dose at one time (take the contents and grind them)

big honey pill

One-time oral dose (need to be crushed)

Granules

One-time oral dose (need to be crushed)

other solid

oral dose

[0074] This shows that the amount of the sample to be inspected used by the method of the present invention is small, so as to damage the interests of innocent operators as little as possible.

[0075] 2. Preparation of the test solution

[0076] Take medicine, health food or food, add 20ml of 90% ethanol, add 2g of benzoic acid, and shake for 1 minute.

[0077] 3. Measure and judge the resu...

Embodiment 3

[0079] Embodiment 3, test whether there is promethazine substance in detection medicine, health food and food

[0080] Adopt the method of embodiment 1 to detect 20 batches of samples rapidly (all are the sampling samples of drug supervision department). In addition, according to the "2010 Chinese Pharmacopoeia Standard", the samples were tested by HPLC method to verify the screening results.

[0081] The HPLC detection method recorded in the Chinese Pharmacopoeia standard in 2010 is as follows:

[0082] Chromatographic column: Octylsilane bonded silica gel as packed column

[0083] Detection wavelength: 254nm;

[0084] Mobile phase: acetonitrile-trifluoroacetic acid;

[0085] Temperature: room temperature 23°C;

[0086] Flow rate: 1.0ml / min; injection volume: 5μl.

[0087] According to the table below, take various solid samples for one oral dose, add 20ml of 90% ethanol, add 2g of benzoic acid, and shake for 1 minute. Then, it was measured with a measuring instrument...

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Abstract

The invention relates to a method for rapid detection of promazine substances in a product, and particularly relates to the method for detection whether the product suspected to be mixed with the promazine substances contains the promazine substances. The method comprises the following steps: (1) taking a proper amount of the product, mixing with a special solvent, shaking or carrying out ultrasonic assisted dissolution, and thus obtaining a mixed test solution; (2) detecting specific electrochemical parameters of the mixed test solution by using a proper detector based on a specific electrochemical method; and (3) according to the value of the parameters, judging whether the promazine substance central nervous inhibition substances are possibly added illegally in the product. The method has no need of filtering the sample solution; time consuming of the whole detection processes is only 2-3 min; and the method is rapid, convenient and safe, and is high in sensitivity and friendly to the environment.

Description

technical field [0001] The invention relates to the technical field of analysis of medicines, health food or food, in particular to a method for rapidly screening drugs, health food or food illegally added promethazine central nervous system inhibitors based on an electrochemical method. Background technique [0002] Promethazines have an inhibitory effect on the central nervous system. Its representative compound, promethazine hydrochloride, can block the H1 receptors of smooth muscle, capillary wall and other tissues, thereby playing a competitive antagonistic role with histamine. pain effect. And can lower body temperature and antiemetic. Another representative compound, chlorpromazine hydrochloride, has a stabilizing effect on the central nervous system in small doses, and has antipsychotic effects in continuous use in large doses. When it falls below normal body temperature, the metabolism is reduced, which is called artificial hibernation. It is mainly used for anti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/28G01N27/26
Inventor 王铁松车宝泉纪菁
Owner BEIJING INST FOR DRUG CONTROL
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