Pharmaceutical composition as well as preparation method and application thereof
A composition and drug technology, applied in the field of medicine, can solve the problems of nerve cell damage, lack of treatment methods, loss, etc., and achieve the effect of nerve damage protection, mild reaction conditions, and simple operation
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[0047] Furthermore, in some embodiments, the preparation method of the pharmaceutical composition of the present invention further includes the step of purifying the extract.
[0048] The purification can be carried out by methods known to those skilled in the art such as chromatographic separation. Wherein the chromatographic separation method may be gel filtration, ion exchange chromatography, adsorption chromatography, affinity chromatography and other methods.
[0049] In some embodiments, in the preparation method of the pharmaceutical composition of the present invention, the purification is adsorption chromatography adsorption.
[0050] Further, in some specific embodiments, the purification is specifically adsorption on a macroporous adsorption resin.
[0051] Macroporous adsorption resin is a kind of polymer adsorption resin with no exchange group and macroporous structure. It has a good macroporous network structure and large specific surface area, and can selective...
Embodiment 1
[0087]Take 100 g of rhubarb medicinal material in Lhasa, add 800 ml of water, extract by reflux, filter, pass the filtrate through a macroporous resin column (D101 type macroporous resin, column 1Kg) that has been balanced with water in advance, elute with water and 50% ethanol-water solution successively, collect 50% ethanol-water eluate, filtered, and the filtrate was decompressed to recover the solvent to dryness, and ground into a fine powder to obtain 12 g of Lhasa rhubarb extract, numbered 20130401.
Embodiment 2
[0089] Get 100g of Lhasa rhubarb medicinal material, add 800ml95% ethanol, reflux extraction, filter, the filtrate is concentrated to dryness under reduced pressure, add water 100ml to dissolve and let it stand overnight, take the supernatant and pass it through the macroporous resin column (D101 type macroporous resin , packing column 1Kg), successively eluted with water, 50% ethanol-water solution, collected 50% ethanol-water eluate, filtered, and the filtrate decompressed and recovered the solvent to dryness, ground into fine powder, and obtained 10.2 g of Lhasa Rhubarb extract, The serial number is 20130402.
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