Pharmaceutical composition as well as preparation method and application thereof

A composition and drug technology, applied in the field of medicine, can solve the problems of nerve cell damage, lack of treatment methods, loss, etc., and achieve the effect of nerve damage protection, mild reaction conditions, and simple operation

Active Publication Date: 2014-12-24
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, except for PD patients who can prolong their life and improve their quality of life through rational drug use, the treatment effects of other diseases are not ideal
The central nervous system injury diseases include ischemic encephalopathy, hemorrhagic encephalopathy, motor neuron disease, etc. Pathologically, nerve cells are damaged, missing or dead, which seriously damages nerve function and leads to hemiplegia, aphasia, mental retardation or Coma, even death, is a disease that seriously threatens human health, and so far there is still a lack of effective treatment

Method used

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  • Pharmaceutical composition as well as preparation method and application thereof
  • Pharmaceutical composition as well as preparation method and application thereof
  • Pharmaceutical composition as well as preparation method and application thereof

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preparation example Construction

[0047] Furthermore, in some embodiments, the preparation method of the pharmaceutical composition of the present invention further includes the step of purifying the extract.

[0048] The purification can be carried out by methods known to those skilled in the art such as chromatographic separation. Wherein the chromatographic separation method may be gel filtration, ion exchange chromatography, adsorption chromatography, affinity chromatography and other methods.

[0049] In some embodiments, in the preparation method of the pharmaceutical composition of the present invention, the purification is adsorption chromatography adsorption.

[0050] Further, in some specific embodiments, the purification is specifically adsorption on a macroporous adsorption resin.

[0051] Macroporous adsorption resin is a kind of polymer adsorption resin with no exchange group and macroporous structure. It has a good macroporous network structure and large specific surface area, and can selective...

Embodiment 1

[0087]Take 100 g of rhubarb medicinal material in Lhasa, add 800 ml of water, extract by reflux, filter, pass the filtrate through a macroporous resin column (D101 type macroporous resin, column 1Kg) that has been balanced with water in advance, elute with water and 50% ethanol-water solution successively, collect 50% ethanol-water eluate, filtered, and the filtrate was decompressed to recover the solvent to dryness, and ground into a fine powder to obtain 12 g of Lhasa rhubarb extract, numbered 20130401.

Embodiment 2

[0089] Get 100g of Lhasa rhubarb medicinal material, add 800ml95% ethanol, reflux extraction, filter, the filtrate is concentrated to dryness under reduced pressure, add water 100ml to dissolve and let it stand overnight, take the supernatant and pass it through the macroporous resin column (D101 type macroporous resin , packing column 1Kg), successively eluted with water, 50% ethanol-water solution, collected 50% ethanol-water eluate, filtered, and the filtrate decompressed and recovered the solvent to dryness, ground into fine powder, and obtained 10.2 g of Lhasa Rhubarb extract, The serial number is 20130402.

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Abstract

The invention belongs to the field of medicines, and discloses a pharmaceutical composition as well as a preparation method and an application thereof. The pharmaceutical composition comprises piceatannol 3'-O-glucoside, deoxyrhapontin, polydatin and rhapontigenin-3'-O-beta-D-glucoside. The pharmaceutical composition has a remarkable protection function for the nerve injuries caused by hydrogen peroxide and the protection function is relative to the expression which is capable of inhibiting iNoS; and the pharmaceutical composition can be used for preparing an iNoS expression inhibitor and a drug for preventing and / or treating central nervous system diseases. The pharmaceutical composition can be prepared by using Lasa rheum officinale as a raw material, the operation is simple, the raw materials are easy to get and the reaction condition is mild, so that the Lasa rheum officinale is suitable for the large-scale preparation of the pharmaceutical composition.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition and its preparation method and application, in particular to the application of the pharmaceutical composition in the preparation of drugs for preventing and / or treating diseases of the central nervous system. Background technique [0002] The central nervous system consists of the brain and spinal cord (the brain and spinal cord are the central parts of various reflex arcs) and is the most important part of the human nervous system. The central nervous system receives incoming information from all parts of the body, and after it is integrated and processed, it becomes a coordinated motor efferent, or is stored in the central nervous system to become the neural basis of learning and memory. Human thinking is also a function of the central nervous system. Therefore, the central nervous system is affected by pathogenic factors to develop pathologica...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7034A61P25/00A61P25/28
Inventor 龚云麒陈锦锌方芳刘一丹
Owner KPC PHARM INC
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