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Multivitamin solid lipid particles and preparation method thereof

A technology of multivitamins and solid lipids, applied in food preparation, pharmaceutical formulations, cosmetic formulations, etc., can solve problems such as limited application scope, layered demulsification, thermodynamic instability, etc., and achieve the effect of solving application defects

Inactive Publication Date: 2015-01-28
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The number of liposome-loaded active substances is limited, and the structure is relatively unstable; multiple emulsions are a thermodynamically unstable system, which is prone to delamination and demulsification; the external water phase of water-in-oil emulsions is oil, and the application range is limited

Method used

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  • Multivitamin solid lipid particles and preparation method thereof
  • Multivitamin solid lipid particles and preparation method thereof
  • Multivitamin solid lipid particles and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The combination is a formula:

[0025]

[0026] Preparation method of solid lipid particles loaded with multivitamins:

[0027] The first step: Weigh 5g vitamin C, 1g vitamin A acetate and 25g deionized water, heat and stir in a water bath at 70℃ to completely dissolve and stir evenly to form an aqueous solution containing water-soluble vitamins as the internal water phase;

[0028] Weigh 1g vitamin E acetate, 29.9g corn oil, 5g glycerol, 10g polyglycerol castor oil, 11g glycerol monostearate, heat and stir in a water bath at 70°C to completely dissolve and stir evenly, as the oil phase;

[0029] Step 2: Pour the internal water phase into the oil phase slowly, while stirring for 10 minutes, after mixing uniformly, high shear at 16000rpm for 5 minutes;

[0030] The third step: Put 12.1 g of decapolyglycerol monolaurate into the mixture, heat it in a water bath at 50°C, and stir to mix uniformly to obtain a lipid system, and cool to room temperature to solidify to obtain lipid micr...

Embodiment 2

[0033] The combination is a formula:

[0034]

[0035] Preparation method of solid lipid particles loaded with multivitamins:

[0036] Step 1: Weigh 2g of vitamin C, 1g of vitamin A acetate and 22g of deionized water, heat and stir in a water bath at 70°C to completely dissolve and stir evenly to form an aqueous solution containing water-soluble vitamins as the internal water phase;

[0037] Weigh 2g vitamin E acetate, 35g coconut oil, 5g glycerol, 10g polyglycerol castor oil, 11g acetylated monoglyceride, heat and stir in a water bath at 70°C to completely dissolve and stir it, as the oil phase;

[0038] Step 2: Pour the internal water phase into the oil phase slowly, while stirring for 10 minutes, mix well, and homogenize at 600bar high pressure for 3 cycles;

[0039] The third step: Put 12g polyoxyethylene sorbitan fatty acid ester into the mixture, heat it in a water bath at 50°C, and stir to mix uniformly to obtain a lipid system, and cool to room temperature to solidify to obtain ...

Embodiment 3

[0042] The combination is a formula:

[0043]

[0044] Preparation method of solid lipid particles loaded with multivitamins:

[0045] The first step: Weigh 2g vitamin C, 2g vitamin B and 26g deionized water, heat and stir in a water bath at 70℃ to completely dissolve and stir evenly to form an aqueous solution containing water-soluble vitamins as the internal water phase;

[0046] Weigh 1g vitamin E, 1g vitamin A, 29.9g corn oil, 5g glycerol, 10g sorbitan monostearate, 11g glycerol monostearate, heat and stir in a water bath at 70°C to completely dissolve and stir evenly. As the oil phase

[0047] Step 2: Pour the internal water phase into the oil phase slowly, while stirring for 10 minutes, mix well, and ultrasonic for 15 minutes;

[0048] The third step: Put 12.1 g of hexaglycerol monolaurate into the mixture, heat it in a water bath at 50°C, and stir to mix uniformly to obtain a lipid system, and cool to room temperature to solidify to obtain lipid particles loaded with multiple vi...

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Abstract

The invention discloses multivitamin solid lipid particles and a preparation method thereof. The multivitamin solid lipid particles are loaded with vitamin A, vitamin A acetate, vitamin B, vitamin C, vitamin E and vitamin E acetate, and comprise the following components in percentage by weight: 1-2% of vitamin A, 1-5% of vitamin A acetate, 1-5% of vitamin B, 1-5% of vitamin C, 1-2% of vitamin E, 1-2% of vitamin E acetate, 20-28% of a solvent, 20-25% of an emulsifier and 36-50% of lipid material. The preparation method comprises the following steps: mixing the lipid material with the emulsifier as an oil phase; adding water-soluble vitamins into the solvent as an internal aqueous phase; adding the internal aqueous phase into a mixture of the liquid oil phase and oil-soluble vitamins, pre-emulsifying, performing ultrasonic emulsification, performing high shearing dispersion or high pressure homogenization, adding the oil-in-water emulsifier, stirring uniformly to obtain the lipid system, cooling to room temperature, and solidifying to obtain the solid lipid particles loaded with multivitamins.

Description

Technical field [0001] The invention belongs to the technical field of carrier systems in cosmetic preparation technology, and relates to a preparation method of micro-nano-level carriers, in particular to a micro-nano solid lipid particle with multiple vitamins as active ingredients and a preparation method thereof. Background technique [0002] Vitamins are a class of organic substances necessary to maintain human life activities, and they are also important active substances to maintain human health. The content of vitamins in the body is relatively small, but they play an important role in the growth, metabolism and development of the human body. Once lacking, it will cause the corresponding vitamin deficiency, causing harm to human health. [0003] Lipid nanoparticle technology is a nano-scale carrier system that uses lipid materials from natural sources as carrier materials and is prepared by modern nanotechnology that can be used to load active ingredients. Lipid nanoparti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/67A61K8/92A61K8/14A23L1/30A23L33/15
Inventor 夏强胡才彪
Owner SOUTHEAST UNIV
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