Hollow type magnetic nanoparticle contrast agent.

Abstract

The invention discloses a hollow type magnetic nanoparticle contrast agent. The microsphere has a hollow inorganic / organic / inorganic three layer structure, a cavity is located in the center of the microsphere and is filled with air; the inner layer is Fe3O4 magnetic particles; the intermediate layer is core-shell polymer nanoparticles obtained by free radical copolymerization of polyacrylic acid-divinyl benzene, and the copolymer and the Fe3O4 magnetic particle in the inner layer form stable coordination bonds or ionic bonds through inner surface carboxyl group and ferric salt; and the outer layer is silicon dioxide, and the carboxyl group on the surface of microspheres and silicon hydroxyl on silica surface are connected through hydrogen-bond interaction. The material has the advantages that the polymer microsphere belongs to the nanometer particle, the inner Fe3O4 magnetic particles enable the contrast agent to target, the silica hollow microspheres have good biological compatibility and the mechanical stability, and internal cavity can produce strong echo signal in contrast mode.

Description

technical field [0001] The invention relates to a contrast agent for medical detection, in particular to a multilayer organic / inorganic composite structure nano microsphere with magnetic function, which belongs to the field of medical technology. Background technique [0002] In recent years, molecular imaging technology has attracted extensive attention because it can provide important information for the diagnosis and monitoring of diseases in living tissues (Campbell R. E., Chang C. J. Curr Opin Chem Biol , 2010, 14(1):1-2.). Among many imaging modes, ultrasound imaging, as a non-invasive biomedical imaging mode, has important research value due to its advantages of safe and timely imaging and diagnosis, low price, lightness and quickness, and wide application. However, the difference in echo signals between different biological tissues often hinders the accuracy of diagnosis. In order to better obtain accurate information of specific tissues, people usually use the meth...

AI Technical Summary

Problems solved by technology

However, this method still has certain limitations, such as hollow SiO 2 The size of the spheres is too large and does not reach the nanoscale structure, which makes it difficult to be used for in vivo imaging, and it is difficult to carry out further connection without functional group modification

Therefore, the contrast agents currently used in clinical practice cannot simultaneously meet the requirements of good biocompatibility, mechanical stability, targeting performance, nanostructure, and functional group modification.

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