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Ultra-high-selectivity bisphenol substitute template molecularly imprinted polymer and application thereof

A technology for replacing templates and molecular imprinting, applied in selective adsorption, ion exchange, other chemical processes, etc., can solve the problem that bisphenols cannot be used to replace templates, etc., and achieve ultra-high specific selectivity and high-efficiency detection

Active Publication Date: 2015-02-11
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The substitute templates used in the currently reported bisphenol substitute template polymers are all one or more of the bisphenols, and cannot be used for all bisphenol substitute templates

Method used

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  • Ultra-high-selectivity bisphenol substitute template molecularly imprinted polymer and application thereof
  • Ultra-high-selectivity bisphenol substitute template molecularly imprinted polymer and application thereof

Examples

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Embodiment 1

[0024] Dissolve 1 mmol of the surrogate template molecule 1,1,1-tri-p-hydroxybenzene into 4 mmol of the functional monomer 4-vinylpyridine, 20 mmol of the crosslinker ethylene glycol dimethacrylate and 0.04 g of the initiator azobis Prepare a pre-polymerization solution in acetonitrile (5.6 mL) of isobutyronitrile, place the pre-polymerization solution in an ice bath for 10-15 minutes and mix it with ultrasound, then blow nitrogen gas for 10 minutes to remove oxygen in the system, seal it and refrigerate it at 4°C for 2 hours , and then placed at 60°C for 24h. The white massive polymer produced by the reaction is pulverized, ground, sieved and settled with acetone to obtain a polymer with a particle size of 45-63 μm. The obtained polymer was subjected to Soxhlet extraction using methanol acetic acid (9:1, v / v) and methanol as extraction solvents in order to remove template molecules and other interfering substances, and the obtained polymer was dried in a vacuum oven at 60°C ...

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Abstract

The invention provides a preparation method and an application method of an ultra-high-selectivity bisphenol substitute template molecularly imprinted polymer. According to the invention, substitute template molecules, a cross-linking agent, a functional monomer, and an initiator are dissolved in a pore-forming solvent, such that a pre-polymerization solution is prepared; a polymerization reaction is carried out for 24-48h under a temperature of 50-70 DEG C; a white block-shaped polymer obtained in the polymerization reaction is ground, sieved, and settled, such that polymer particles with a particle size of 45-63[mu]m are obtained; the obtained polymer is subjected to Soxhlet extraction sequentially by using methanol / acetic acid and methanol as extraction solvents; and residual substitute template molecules and un-reacted substances are removed, such that the substitute template molecularly imprinted polymer is obtained. The substitute template molecularly imprinted solid-phase extraction material provided by the invention has high specific selectivity and enrichment capability upon bisphenol compounds. With the material, a template leakage problem during trace analysis is solved. The polymer can be used in separation and enrichment of bisphenol endocrine interferents in a complex substrate.

Description

technical field [0001] The invention relates to an ultra-high selective enrichment and purification of bisphenol endocrine disruptor substitute template molecularly imprinted polymer and its preparation and application, belonging to the field of environmental monitoring and new materials. Background technique [0002] Bisphenols are widely used raw materials or additives in polymer materials. Bisphenols may be released during the production, manufacture, and use of materials. Studies have shown that bisphenols have gene mutagenesis and estrogen interference (Environ.Toxicol.17 (2002) 80; Environ.Toxicol.Pharmacol.19 (2005) 121). Among them, bisphenol A is the raw material of polycarbonate, epoxy resin and phenolic resin, and is also an important material for anti-oxidation and stabilization treatment in surgical repair, and is widely used in food packaging and container inner wall coating. Among them, BPA is an endocrine disruptor with estrogen activity, and trace or even ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F222/14C08F212/36C08F226/06C08F220/06C08F220/56C08J9/28C08J9/26B01J20/26B01D15/08
Inventor 陈吉平孙晓丽王金成
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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