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Preparation method of acidic homogeneous polysaccharide from gynura divaricata having effect of reducing blood glucose

A technology for reducing blood sugar from Radix Scutellaria alba, which is applied in the field of medicine, can solve the problems of affecting wide application and low extraction rate of the technology, and achieve the effects of high blood sugar-lowering drug activity, high yield, and simple preparation method

Inactive Publication Date: 2015-03-04
FUZHOU GENERAL HOSPITAL OF NANJING MILITARY COMMAND P L A
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Problems solved by technology

However, the current technology has a low extraction rate, which seriously affects its wide application.

Method used

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  • Preparation method of acidic homogeneous polysaccharide from gynura divaricata having effect of reducing blood glucose
  • Preparation method of acidic homogeneous polysaccharide from gynura divaricata having effect of reducing blood glucose
  • Preparation method of acidic homogeneous polysaccharide from gynura divaricata having effect of reducing blood glucose

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Embodiment Construction

[0014] The medicinal material processing method used in the process of the present invention is obtained through experimental comparison. The type and concentration of the extraction solvent, the extraction method, and the number of crushed medicinal materials are studied through an orthogonal design, which ensures the yield of the obtained homogeneous polysaccharide of albino oxalic acid. high. And investigated its hypoglycemic pharmacodynamic activity.

[0015] The research steps and detailed data are as follows:

[0016] 1. Extraction and purification of albino oxalic homogeneous polysaccharide

[0017] 1. Extraction of Polysaccharides from Aphrodisiac Radix

[0018] (1) The medicinal material Baizicao was selected and identified as Baizicai, a plant of the genus Sanqi in the family Asteraceae Gynura divaricata (L.)DC. The properties, characteristics, powder characteristics, and physical and chemical properties of the dried leaves of the medicinal materials should comp...

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Abstract

The invention discloses a preparation method of acidic homogeneous polysaccharide from gynura divaricata having the effect of reducing blood glucose and application. The preparation method disclosed by the invention comprises the following steps of: drying and crushing gynura divaricata as the raw material, degreasing by using 10 times of petroleum ether, thermally extracting decoction dregs obtained after extracting by using 95 wt% of ethanol solution, by using water at 100 DEG C, each time for 2 h, precipitating polysaccharide in extracting solution by using absolute ethyl alcohol to obtain a crude product, deproteinizing the crude product through a papain-Sevag method, passing through a DEAE-SepharoseFastFlow ion exchange column, carrying out gradient elution by using NaCl with the concentrations of 0, 0.1 and 0.3 mol.L<-1>, collecting 0.3 mol.L<-1> NaCl with the flow velocity of 2.5 mL.min<-1>, concentrating eluant in vacuum, thus obtaining acidic homogeneous polysaccharide from gynura divaricata (GDAPs) after dialyzing. The acidic homogeneous polysaccharide prepared by the invention can be mixed with pharmaceutically applicable carriers and used for preparing a medicine for reducing blood glucose. The acidic homogeneous polysaccharide from gynura divaricata disclosed by the invention is high in yield and pharmacodynamics activity for reducing blood glucose and simple in preparation method, and has obvious economic and social benefits.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to a preparation method and application of a homogeneous polysaccharide of albino oxalic acid with hypoglycemic effect. Background technique [0002] Diabetes Mellitus (DM) is one of the most common chronic diseases, which is due to the interaction of genetic and environmental factors, causing absolute or relative insulin secretion and reduced sensitivity of target tissue cells to insulin, causing protein, fat, water and electrolytes, etc. A spectrum of metabolic disorder syndromes in which hyperglycemia is the main hallmark. With the improvement of people's living standards, the aging population and the increase in the incidence of obesity, the incidence of diabetes is increasing year by year. The incidence of diabetes in China has reached 2%. According to statistics, there are 40 million diagnosed diabetic patients in China, and the number is increasing at a rate of...

Claims

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Application Information

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IPC IPC(8): C08B37/00A61K36/896A61P3/10
Inventor 宋洪涛陈磊张钱钱林兵
Owner FUZHOU GENERAL HOSPITAL OF NANJING MILITARY COMMAND P L A
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