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Preparation method for spatholobus suberectus dunn analgesics

A technology of Scutellaria chinensis and analgesic agent, which is applied in the field of preparation of Scutellaria chinensis analgesics, and achieves the effects of loose shape, easy molding, and simplified preparation process.

Active Publication Date: 2015-04-29
贵州省科晖制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the membrane separation technology and freeze-drying technology are used in combination for the separation and concentration of the water extract of Spathiphyllum Spathifolia, and there is no report yet.

Method used

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  • Preparation method for spatholobus suberectus dunn analgesics

Examples

Experimental program
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Effect test

experiment example

[0015] UF-100, UF-50, UF-10, UF-5 lyophilized powder preparation and the mixing ratio of UF-100:UF-50:UF-10:UF-5=5:3:1:1 Freeze-dried powder preparations were used for acetic acid writhing analgesic experiments in mice, and the specific experiments were as follows:

[0016] The mice were randomly divided into 7 groups, each group was half male and half female, UF-100, UF-50, UF-10, UF-5, and the mixing ratio was UF-100:UF-50:UF-10:UF-5= The 5:3:1:1 mixed freeze-dried powder preparation consists of 5 administration groups, aspirin group and normal saline group, with 12 mice in each group. The aspirin (0.2g / ml) group and the 5 drug groups were administered with 0.2g / ml of the corresponding membrane retentate freeze-dried powder solution, and each group was administered with a volume of 0.2ml / 10g body weight, for 3 consecutive days . 60 minutes after the last administration, animals in each group were intraperitoneally injected with 0.2 ml of 0.6% acetic acid solution. Observe...

Embodiment 1

[0023] A preparation method of Jixueteng analgesic granules, comprising the following steps:

[0024] (1) Grind 1kg of the medicinal material of Spatholobus Spatholobus, decoct it twice with 5 times of water for 2 hours each time, concentrate until the density is 1.0, and let it stand for 24 hours;

[0025] (2) Filter and discard the precipitate;

[0026] (3) Dilute the Filtrate of Spatholobus Spatholobus by 10 times with distilled water, and perform membrane separation. The parameters of membrane separation are: temperature: 30°C; pressure: ultrafiltration membrane 0.2Mpa, nanofiltration membrane 0.2Mpa;

[0027] (4) Collect and obtain UF-100, UF-50, UF-10, UF-5, a total of 4 stages of membrane separation liquid, and vacuum freeze-dry to obtain freeze-dried powder;

[0028] (5) Based on granules containing 60 mg of active compound, UF-100, UF-50, UF-10, UF-5 and UF-100:UF-50:UF-10:UF-5=5:3:1 :1 each 60mg of mixed freeze-dried powder, add dextrin 1540mg, sucrose 8400mg respe...

Embodiment 2

[0030] A preparation method of Caulis Spatholobus analgesic capsules, comprising the following steps:

[0031] (1) Grind 1kg of the medicinal material of Spatholobus Spatholobus, decoct it twice with 10 times of water, 1 hour each time, concentrate to a density of 0.8, and let stand for 24 hours;

[0032] (2) Filter and discard the precipitate;

[0033] (3) Dilute the Filtrate of Spatholobus Spatholobus by 5 times with distilled water, and perform membrane separation. The parameters of membrane separation are: temperature: 35°C; pressure: ultrafiltration membrane 0.1Mpa, nanofiltration membrane 0.3Mpa;

[0034] (4) Collect and obtain UF-100, UF-50, UF-10, UF-5, a total of 4 stages of membrane separation liquid, and vacuum freeze-dry to obtain freeze-dried powder;

[0035] (5) Based on the capsule containing 60 mg of active compound, UF-100, UF-50, UF-10, UF-5 and the mixing ratio is UF-100:UF-50:UF-10:UF-5=5: 60 mg of 3:1:1 mixed freeze-dried powder, 135 mg of starch, 35 mg ...

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Abstract

The invention discloses a preparation method for spatholobus suberectus dunn analgesics, which comprises the following steps: crushing spatholobus suberectus dunn, decocting the spatholobus suberectus dunn in water twice for 1-2 h every time, concentrating the decoction, and leaving the decoction to stand; filtering the decoction and rejecting sediment; diluting the spatholobus suberectus dunn filtrate with distilled water, and conducting membrane separation; collecting four stages of membrane-separated liquid UF-100, UF-50, UF-10 and UF-5, and conducting vacuum freeze drying to obtain freeze-dried powder; adding conventional adjuvants into the freeze-dried powder UF-100, UF-50, UF-10 and UF-5 and mixed freeze-dried powder respectively to prepare various preparations by conventional techniques, wherein the mixing ratio of UF-100 to UF-50 to UF-10 to UF-5 of the mixed freeze-dried powder is 5:3:1:1. The preparation method for the spatholobus suberectus dunn analgesics, provided by the invention, has the characteristics of safety, environment friendliness, no toxicity and simple process.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a preparation method of a spatula analgesic. Background technique [0002] The Pharmacopoeia of Spatholobus Spatholobus is included as Dense Flower Bean ( Spatholobus suberectus Dunn ) dry canes, born in forests or shrub forests, distributed in Guangxi, Guangdong, Yunnan, Guizhou and other places. It is named for its bright red vine juice, which resembles chicken blood. Its medicinal use has a history of thousands of years. It is a typical traditional Chinese medicine for promoting blood circulation and removing blood stasis. Traditional Chinese medicine believes that it is a strong blood-tonifying medicine. It has the effects of removing congestion, generating new blood, and smoothing tendons. , numbness and paralysis, blood deficiency and chlorosis, amenorrhea, and irregular menstruation (Dictionary of Chinese Medicine, 1986). [0003] Membrane separation t...

Claims

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Application Information

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IPC IPC(8): A61K36/486A61P29/00
CPCA61K9/1652A61K9/2059A61K9/4866A61K36/486A61K2236/331A61K2236/39A61K2236/51A61K2236/53
Inventor 杨迺嘉刘建华高玉琼霍昕王仕梅
Owner 贵州省科晖制药有限公司
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