Application of a pharmaceutical composition in the preparation of medicaments for treating senile dementia

A technology of Alzheimer's disease and composition, which is applied in the field of medicine, can solve the problems of Alzheimer's disease, such as unclear etiology and onset preparations, loss of neurons, side effects, etc.

Active Publication Date: 2017-11-07
DONGGUAN ZHIJIAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the research and development of drugs for the treatment of Alzheimer's disease has attracted great attention from the medical circles all over the world. With the in-depth research of the neurophysiology, biochemistry and pharmacology of the elderly, the research and development of drugs for the treatment of Alzheimer's disease has also made great progress. Progress, however, so far, the etiology and pathogenesis of Alzheimer's disease are still unclear, the main theory of the pathogenesis of Alzheimer's disease is the amyloid peptide hypothesis: the precipitation of condensed Aβ in the brain parenchyma initiates a pathological cascade, leading to nerve fiber Tangle formation, neuronal loss and manifestations of dementia
At present, the drugs for the treatment of Alzheimer's disease mainly include cholinesterase inhibitors, cerebral vasodilators, calcium antagonists, drugs to prevent Aβ deposition, inhibitors of β and γ secretion of myrrh, anti-inflammatory drugs, and drugs with potential anti-senile dementia effects. Natural ingredients, although the above drugs have shown certain curative effect in clinical application, there are serious and unavoidable side effects during long-term use

Method used

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  • Application of a pharmaceutical composition in the preparation of medicaments for treating senile dementia
  • Application of a pharmaceutical composition in the preparation of medicaments for treating senile dementia
  • Application of a pharmaceutical composition in the preparation of medicaments for treating senile dementia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1, capsule preparation of the pharmaceutical composition of the present invention

[0027] prescription:

[0028] Polygonum multiflorum 8kg Cistanche 5kg Salvia miltiorrhiza 12kg

[0029] Astragalus 12kg Ginkgo biloba 12kg Epimedium 8kg

[0030] Pueraria 16kg, Arborvitae leaves 16kg, Albizia juniper skin 16kg

[0031] Angelica 20kg Morinda officinalis 18kg Ginger 10kg

[0032] Lycium barbarum 12kg.

[0033] Preparation process: the raw materials such as Polygonum multiflorum, Cistanche, Salvia, Astragalus, Ginkgo biloba, Epimedium, Pueraria arborvitae, Albizia bark, Angelica, Morinda officinalis, ginger, Lycium barbarum and other raw materials of the above prescription weight are removed, washed Clean, dry, decoct twice, filter out the dregs to get the juice, mix the filtrate twice, concentrate and dry and mix evenly; add compressible starch, lactose and low-substituted hydroxypropyl cellulose, mix evenly, add 60% ethanol Soft material is made from solut...

Embodiment 2

[0034] Embodiment 2, the capsule preparation of pharmaceutical composition of the present invention

[0035] prescription:

[0036] Polygonum multiflorum 10kg Cistanche 8kg Salvia miltiorrhiza 15kg

[0037] Astragalus 18kg Ginkgo biloba 15kg Epimedium 12kg

[0038] Pueraria 12kg, Arborvitae leaves 10kg, Albizia juniper skin 12kg

[0039] Angelica 10kg Morinda officinalis 12kg Ginger 5kg

[0040] Lycium barbarum 6kg.

[0041]Preparation process: the raw materials such as Polygonum multiflorum, Cistanche, Salvia, Astragalus, Ginkgo biloba, Epimedium, Pueraria arborvitae, Albizia bark, Angelica, Morinda officinalis, ginger, Lycium barbarum and other raw materials of the above prescription weight are removed, washed Clean, dry, decoct twice, filter out the dregs to get the juice, mix the filtrate twice, concentrate and dry and mix evenly; add compressible starch, lactose and low-substituted hydroxypropyl cellulose, mix evenly, add 60% ethanol Soft material is made from soluti...

Embodiment 3

[0042] Embodiment 3, tablet preparation of pharmaceutical composition of the present invention

[0043] prescription:

[0044] Polygonum multiflorum 20kg Cistanche 15kg Salvia miltiorrhiza 18kg

[0045] Astragalus 25kg Ginkgo biloba 25kg Epimedium 16kg

[0046] Pueraria 8kg, Arborvitae leaves 8kg, Albizia Julibrissin skin 8kg

[0047] Angelica 5kg Morinda officinalis 6kg Ginger 2kg

[0048] Lycium barbarum 2kg.

[0049] Preparation process: the raw materials such as Polygonum multiflorum multiflorum, Cistanche, Salvia miltiorrhiza, Astragalus, Ginkgo biloba, Epimedium, Pueraria arborvitae, Albizia juniper, Angelica, Morinda officinalis, ginger, Lycium barbarum and other raw materials of the above prescription weight are added with starch, paste The essence and low-substituted hydroxypropyl cellulose are mixed evenly, and an appropriate amount of 60% ethanol is added to the mixed powder, and the soft material is made after mixing evenly, and dried below 60°C. After drying,...

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Abstract

The invention belongs to the technical field of medicine, and relates to application of a medicine composition in preparing medicine curing senile dementia. The medicine composition comprises the following components: fried fleece-flower root, desertliving cistanche, radix salviae miltiorrhizae, hoantchy root, gingko leaves, epimedium, kudzuvine root, cacumen biotae, cortex albiziae, angelica, radix morindae officinalis, ginger and Chinese wolfberry. The medicine composition is a pure Chinese herbal preparation, follows the principle of strengthening the body resistance to eliminate pathogenic factors and treating both symptoms and root causes, uses all the components, plays the role of tonifying liver and kidney, nourishing and activating blood, expanding blood vessels, reducing phlegm for resuscitation, reducing blood sugar, blood fat and cholesterol, and improving blood circulation and brain flow rate, has a remarkable effect in curing senile dementia, is low in side effect, and has a wide medicine application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine and relates to the application of a pharmaceutical composition in the preparation of medicaments for treating senile dementia. Background technique [0002] With the improvement of living standards in modern society, people's average life expectancy is increasing year by year, and the aging phenomenon of the global population is serious. In recent years, various diseases of the elderly have plagued the health of the elderly, especially the increasing incidence of Alzheimer's disease, which has become the number one killer that endangers the health of the elderly. Alzheimer's disease is a neurodegenerative disease with insidious onset and progressive development. Clinically, it is characterized by memory impairment, aphasia, apraxia, agnosia, impairment of visuospatial skills, executive dysfunction, and changes in personality and behavior. With the development of the disease, patients will gradua...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9068A61P25/28
Inventor 刘永红
Owner DONGGUAN ZHIJIAN MEDICAL TECH
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