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A kind of animal-derived nerve scaffold and preparation method thereof

An animal-derived, nerve-based technology, applied in the field of nerve repair, can solve problems such as impaired donor site function, nerve damage, and insufficient supply of autologous nerves

Active Publication Date: 2017-07-21
DONGGUAN REVOLUTION PROD DESIGN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the deficiencies of the prior art, the present invention provides an animal-derived nerve scaffold and its preparation method. The nerve scaffold is derived from animals, which solves the problem of insufficient supply of autologous nerves, and also solves the problem that autologous nerve transplantation will inevitably cause new nerves. Injury, a problem that leads to impaired function of the donor site, has profound implications for nerve repair

Method used

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  • A kind of animal-derived nerve scaffold and preparation method thereof

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Effect test

Embodiment 1

[0021] Embodiment 1: the preparation method of the animal-derived nerve scaffold, comprising the following steps:

[0022] 1) Animal-derived film powder: animal-derived blood vessels are freeze-dried, sterilized and ground into powder to obtain animal-derived film powder;

[0023] 2) Preparation of stent: completely dissolve the animal-derived film material powder in dichloromethane, disperse uniformly by ultrasonic to obtain a slurry, transfer it into the mold cavity of the film-making mold, and place horizontal and vertical magnesium in the mold cavity along the stent forming direction. Zinc alloy wire, the magnesium-zinc alloy wire is immersed in the slurry, the solvent is naturally volatilized and dried, vacuumized for 48 hours, and dried at low temperature, and the dried stent film material wraps the magnesium wire to obtain the animal-derived nerve stent.

Embodiment 2

[0024] Embodiment 2: the preparation method of the animal-derived nerve scaffold, comprising the following steps:

[0025] 1) Animal-derived film powder: animal-derived neural tube is freeze-dried, sterilized and ground into powder to obtain animal-derived film powder;

[0026] 2) Preparation of stents: Dissolve the animal-derived film powder in dichloromethane completely, disperse it uniformly by ultrasonic to obtain a slurry, and transfer it into the mold cavity of the film-making mold. Degrading the metal wire, immersing the degradable metal wire in the slurry, naturally volatilizing and drying the solvent, vacuuming for 48 hours, drying at low temperature, and wrapping the magnesium wire with the dried stent film to obtain the animal-derived nerve stent.

Embodiment 3

[0027] Embodiment 3: the preparation method of the animal-derived nerve scaffold, comprising the following steps:

[0028] 1) Animal source film powder: animal source intestinal tract is freeze-dried, sterilized and ground into powder to obtain animal source film powder;

[0029] 2) Preparation of stents: Dissolve the animal-derived film powder in dichloromethane completely, disperse it uniformly by ultrasonic to obtain a slurry, and transfer it into the mold cavity of the film-making mold. Degrading the metal wire, immersing the degradable metal wire in the slurry, naturally volatilizing and drying the solvent, vacuuming for 48 hours, drying at low temperature, and wrapping the magnesium wire with the dried stent film to obtain the animal-derived nerve stent.

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Abstract

An animal-derived nerve scaffold and a manufacturing method therefor. The animal-derived nerve scaffold comprises a scaffold membrane (1) and a degradable metal wire (2) wrapped by the scaffold membrane (1). The primary constituents of the scaffold membrane (1) are animal-derived blood vessels, lymphatic vessels, neural tubes or intestines. The manufacturing method comprises the steps of preparing an animal-derived membrane powder and wrapping the degradable metal wire (2) with the scaffold membrane (1).

Description

technical field [0001] The invention relates to the technical field of nerve repair, in particular to an animal-derived nerve scaffold and a preparation method thereof. Background technique [0002] Peripheral nerve injury or rupture due to various trauma causes the decrease or loss of sensory and motor function of the injured person. Severe peripheral nerve injury often results in paralysis or permanent loss of labor. Peripheral nerve injury has a high incidence in my country. According to statistics, among trauma patients, nerve injury in the limbs accounts for about 10% of the total number of injuries, and about 60% of firearm injuries and fractures are combined with nerve injury. Therefore, it is necessary to find an ideal treatment method for peripheral nerve injury. For peripheral nerve rupture injuries, if the rupture gap is large, bridging and transplantation of the gap is required to regenerate and repair the ruptured peripheral nerve. [0003] At present, the co...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/36A61L27/50A61L27/04
CPCA61L27/04A61L27/36A61L27/50
Inventor 李扬德
Owner DONGGUAN REVOLUTION PROD DESIGN
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