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Heteroaryl compounds and using methods thereof

A compound and heteroaryl technology, applied in the field of heteroaryl compounds, can solve problems such as cognition or negative symptoms of schizophrenia.

Active Publication Date: 2015-04-29
SUNOVION PHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, current typical or atypical antipsychotics do not address the cognitive or negative symptoms of schizophrenia and only treat positive symptoms in about 40% of patients

Method used

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  • Heteroaryl compounds and using methods thereof
  • Heteroaryl compounds and using methods thereof
  • Heteroaryl compounds and using methods thereof

Examples

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Embodiment Construction

[0019] Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art. All publications and patents mentioned herein are incorporated by reference in their entirety.

[0020] A. Definition

[0021] As used in the specification and appended claims, the indefinite article "a" and the definite article "the" include plural as well as singular referents unless the context clearly dictates otherwise.

[0022] As used herein and unless otherwise indicated, the term "alkyl" refers to a straight or branched chain saturated monovalent hydrocarbon group, wherein the alkyl group may be optionally substituted with one or more substituents. In certain embodiments, the alkyl group has 1 to 20 (C 1-20 ), 1 to 15 (C 1-15 ), 1 to 12 (C 1-12 ), 1 to 10 (C 1-10 ) or 1 to 6 (C 1-6 ) straight-chain saturated monovalent hydrocarbon group of carbon atoms or having 3 to 20 (C 3-20 ), 3 to 15 (C 3-15 ), 3...

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Abstract

Provided herein are heteroaryl compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. In one embodiment, the compounds provided herein are useful for the treatment, prevention, and / or management of various disorders, such as CNS disorders and metabolic disorders, including, but not limited to, e.g., neurological disorders, psychosis, schizophrenia, obesity, and diabetes.

Description

technical field [0001] Provided herein are heteroaryl compounds useful in the treatment of various conditions or diseases, such as central nervous system conditions or diseases and metabolic disorders. Also provided herein are compositions comprising the compounds and methods of their use. Background technique [0002] Central nervous system (CNS) disorders affect a wide range of populations with varying degrees of severity. For example, schizophrenia is a psychopathological disorder of unknown origin that usually first appears in early adulthood and is characterized by features such as psychotic symptoms, staged progression and development, and a decline in social behavior and professional competence. Characteristic psychotic symptoms include thought content disturbances (eg, diverse, fragmented, incoherent, implausible, or simple delusional content or persecutive thoughts) and mental state disturbances (eg, loss of associations, daydreams, incoherence, or incomprehensibil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D471/14C07D487/04A61K31/519A61P25/00
CPCC07D471/04C07D487/04C07D519/00A61K31/4985A61K31/437A61K31/4709A61K31/4745A61P25/00A61P25/04A61P25/06A61P25/08A61P25/14A61P25/16A61P25/18A61P25/22A61P25/24A61P25/28A61P25/30A61P29/00A61P3/00A61P3/04A61P39/02A61P43/00A61P3/10A61K31/4738A61K31/519C07D471/14C07D491/14
Inventor 约翰·埃墨森·坎贝尔菲利普·G·琼斯斯科特·马尔科姆
Owner SUNOVION PHARMA INC
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