Composition preparation capable of increasing bone density and preparation method thereof

A technology for increasing bone density and composition, applied in the direction of drug combination, medical preparations containing active ingredients, bone diseases, etc., to achieve the effect of improving calcium uptake and calcification ability, promoting calcium deposition, and improving intestinal calcium absorption

Inactive Publication Date: 2015-05-06
周基清
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to meet the needs of residents to increase bone density and prevent calcium deficiency, at present, direct calcium supplementation is mainly used to solve the problem. The focus of attention is on calcium absorption. In fact, compared with intestinal calcium absorption, increasing bone density to prevent calcium deficiency More important is the calcium uptake and calcification ability of osteoblasts, that is, the calcium deposition ability, but there is no product similar to enhancing the calcium deposition ability in the market

Method used

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  • Composition preparation capable of increasing bone density and preparation method thereof
  • Composition preparation capable of increasing bone density and preparation method thereof
  • Composition preparation capable of increasing bone density and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0035] The steps of the preparation method of composition preparation:

[0036] 1) Pulverization: the donkey-hide gelatin, milk mineral salt, dextrin, lactose, sucrose and microcrystalline cellulose that weighed are respectively placed in a pulverizer to pulverize;

[0037] 2) Sieving: Sieve the pulverized raw materials separately, among which donkey-hide gelatin, milk mineral salt, dextrin, lactose and sucrose pass through a 60-mesh sieve, microcrystalline cellulose passes through a 80-mesh sieve, and the materials that fail to pass the sieve are re-pulverized , until all components can completely pass through the corresponding screen;

[0038] 3) Mixing: Fully mix the sieved donkey-hide gelatin, milk mineral salt, dextrin, lactose and sucrose to make the color uniform, and set aside;

[0039] 4) Pulping: add the weighed pregelatinized starch into hot purified water to prepare 10% adhesive glue, and set aside;

[0040] 5) Granulation: mix the mixed powder prepared in step 3...

Embodiment 2 4

[0046] The formulation of the composition preparation:

[0047] Element

Embodiment two

Embodiment Three

Embodiment Four

category

donkey-hide gelatin

12 copies

12 copies

12 copies

raw material

milk mineral salt

20 copies

20 copies

20 copies

raw material

Dextrin

20 copies

20 copies

23 copies

Thinner

Mannitol

30 copies

20 copies

30 copies

Thinner

sucrose

15 copies

10 copies

15 copies

Thinner

Magnesium stearate

1 copy

2 copies

3 copies

Glidant

Sodium carboxymethyl cellulose

0.2 parts

2 copies

4 parts

Adhesive

milk flavor

0.5 parts

0.8 parts

1 copy

flavoring agent

[0048] The steps of the preparation method of composition preparation:

[0049] 1) Pulverization: put the donkey-hide gelatin, milk mineral salt, dextrin, mannitol, sucrose and magnesium stearate that we...

Embodiment 5 7

[0059] The formulation of the composition preparation:

[0060] Element

Embodiment five

Embodiment six

Embodiment seven

category

donkey-hide gelatin

20 copies

20 copies

20 copies

raw material

milk mineral salt

12 copies

12 copies

12 copies

raw material

soluble starch

20 copies

20 copies

20 copies

Thinner

lactose

18 copies

10 copies

18 copies

Thinner

sucrose

18 copies

10 copies

18 copies

Thinner

Dextrin

10 copies

10 copies

12 copies

Thinner

polyethylene glycol 6000

1 copy

2 copies

3 copies

Glidant

Methylcellulose

0.2 parts

2 copies

4 parts

Adhesive

black tea flavor

0.5 parts

0.8 parts

1 copy

flavoring agent

[0061] The steps of the preparation method of composition preparation:

[0062] 1) Pulverization: Place the weighed donkey-hide gelat...

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PUM

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Abstract

The invention provides a composition preparation prepared from donkey-hide gelatin and milk mineral salt as key raw materials and capable of enhancing the absorption of calcium and deposition of calcium to increase the bone density and a preparation method thereof. The composition preparation capable of increasing the bone density comprises the following substance components: 16 parts of donkey-hide gelatin, 16 parts of milk mineral salt, 16 parts of dextrin, 38 parts of lactose, 10 parts of sucrose, 1 part of microcrystalline cellulose, 2 parts of pre-gelatinized starch and 0.5 part of chocolate flavor. According to the composition preparation, donkey-hide gelatin has the osteoblast multiplicating effect so that the calcium intake and calcification capacity of osteocytes can be greatly increased and the donkey-hide gelatin is rich in amino acids and thus the absorption of intestinal calcium can be effectively improved; since milk mineral salt contains high-content natural calcium and phosphorus which are easily absorbed and of which the ratio is 2:1, and has the same ratio as that of human skeleton, the calcium deposition is conductively promoted.

Description

technical field [0001] The present invention relates to a composition preparation for enhancing calcium absorption and its preparation method. Specifically, it relates to a kind of donkey-hide gelatin and milk mineral salt as key raw materials, which can enhance calcium deposition and increase bone density while enhancing calcium absorption. Composition preparation and preparation method thereof. Background technique [0002] The population of Chinese residents suffering from calcium deficiency is expanding year by year. Calcium deficiency mainly manifests as bone lesions, such as rickets or osteoporosis. In order to meet the needs of residents to increase bone density and prevent calcium deficiency, at present, direct calcium supplementation is mainly used to solve the problem. The focus of attention is on calcium absorption. In fact, compared with intestinal calcium absorption, increasing bone density to prevent calcium deficiency More important is the calcium uptake and ...

Claims

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Application Information

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IPC IPC(8): A61K35/36A61P3/02A61P19/10A61P19/08A61K35/20
Inventor 周基清
Owner 周基清
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