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Application of traditional Chinese medicine composition in preparation of medicines for treating diabetic nephropathy

A technology for diabetic nephropathy and a composition, applied in the field of medicine, can solve the problems of restricting protein intake, aggravating complications, organ damage, etc., and achieving the effects of improving medication compliance, improving symptoms, and reducing the occurrence of complications

Inactive Publication Date: 2015-05-06
DONGGUAN ZHIJIAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

2) Limit protein intake (≯0.8g / day)
[0004] However, although the method of using chemical hypoglycemic drugs to control blood sugar can control hyperglycemia to a certain extent, due to its own toxic and side effects, it will cause serious damage to the liver, kidney, heart, brain and other organs of the human body, and aggravate the development of complications.
TCM treatment of diabetes pays attention to the whole body conditioning, taking into account both specimens, which is its advantage, but the effect is often slow

Method used

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  • Application of traditional Chinese medicine composition in preparation of medicines for treating diabetic nephropathy
  • Application of traditional Chinese medicine composition in preparation of medicines for treating diabetic nephropathy
  • Application of traditional Chinese medicine composition in preparation of medicines for treating diabetic nephropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Embodiment 1 Chinese medicine composition mixture of the present invention

[0019] Prescription: Astragalus 10kg, Ginseng 5kg, Chuanxiong 12kg, Cypress leaves 11kg, Alisma 12kg, Coptis 14kg, Rehmannia glutinosa 9kg, Ophiopogon japonicus 11kg, Atractylodes macrocephala 20kg, Dandelion 14kg, Pinellia 12kg, Gardenia 7kg, Capillaris 10kg, Lycium barbarum 9kg, Eclipta 11kg, Radix Paeoniae Alba 6kg, Licorice 20kg.

[0020] Preparation method: take each medicinal material, add water 8 times the total weight of the medicinal material, soak for 40 minutes, decoct 3 times, 2 hours each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to an extract with a relative density of 1.15. The relative density is the test result at 60 degrees Celsius. Add ethanol until the alcohol content is 80% (v / v), let it stand for 24 hours, take the supernatant, recover the ethanol until concentrated, add water to 1000ml, stir well, and pack , sterilized by c...

Embodiment 2

[0021] Embodiment 2 Chinese medicine composition tablet of the present invention

[0022] Prescription: Astragalus 20kg, Ginseng 16kg, Ligusticum Chuanxiong 25kg, Cypress leaves 21kg, Alisma 24kg, Coptis 28kg, Rehmannia glutinosa 19kg, Ophiopogon japonicus 23kg, Atractylodes macrocephala 30kg, Dandelion 28kg, Pinellia 27kg, Gardenia 17kg, Capillaris 25kg, Lycium barbarum 18kg, Eclipta 24kg, Radix Paeoniae Alba 16kg, Licorice 30kg.

[0023] Preparation method: take each medicinal material, add water 8 times the total weight of the medicinal material, soak for 40 minutes, decoct 3 times, 2 hours each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to an extract with a relative density of 1.15. The relative density is the test result at 60 degrees Celsius. Add ethanol until the alcohol content is 80% (v / v), let it stand for 24 hours, take the supernatant, recover the ethanol until concentrated, vacuum dry, granulate, and press into tablet...

Embodiment 3

[0024] Embodiment 3 Chinese medicine composition capsule of the present invention

[0025] Prescription: Astragalus 15kg, Ginseng 12kg, Chuanxiong 20kg, Cypress leaves 16kg, Alisma 18kg, Coptis 26kg, Rehmannia glutinosa 18kg, Ophiopogon japonicus 20kg, Atractylodes macrocephala 22kg, Dandelion 17kg, Pinellia 15kg, Gardenia 12kg, Capillary wormwood 21kg, Lycium barbarum 15kg, Eclipta 19kg, Radix Paeoniae Alba 14kg, Licorice 25kg.

[0026] Preparation method: take each medicinal material, add water 8 times the total weight of the medicinal material, soak for 40 minutes, decoct 3 times, 2 hours each time, filter, combine the filtrate, and concentrate the filtrate under reduced pressure to an extract with a relative density of 1.15. The relative density is the test result at 60 degrees Celsius. Add ethanol until the alcohol content is 80% (v / v), let it stand for 24 hours, take the supernatant, recover the ethanol until concentrated, vacuum dry, granulate, and pack into capsules....

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Abstract

The invention belongs to the field of traditional Chinese medicines, and relates to an application of a traditional Chinese medicine composition in preparation of medicines for treating diabetic nephropathy, aiming at the defects of high hepatotoxicity of chemical treatment medicines for treating or preventing diabetic nephropathy and poor effect in the prior art. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-20 parts of radix astragali, 5-16 parts of ginseng, 12-25 parts of rhizoma ligustici wallichii, 11-21 parts of cacumen biotae, 12-24 parts of rhizoma alismatis, 14-28 parts of coptis chinensis, 9-19 parts of radix rehmanniae, 11-23 parts of radix ophiopogonis, 20-30 parts of bighead atractylodes rhizome, 14-28 parts of dandelion,12-27 parts of pinellia ternata, 7-17 parts of gardenia, 10-25 parts of capillary artemisia, 9-18 parts of wolfberry, 11-24 parts of eclipta, 6-16 parts of radix paeoniae alba and 20-30 parts of liquorice. The traditional Chinese medicine composition disclosed by the invention has a good treatment effect in treatment or prevention of diabetic nephropathy, and has low side effect and remarkable clinic expansion value.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the use of a traditional Chinese medicine composition in the preparation of medicines for treating diabetic nephropathy. Background technique [0002] Diabetic nephropathy is glomerulosclerosis caused by abnormal glucose metabolism in diabetes and accompanied by urinary protein content exceeding normal, known as diabetic nephropathy. It is the most serious and harmful chronic complication caused by diabetes, and it is one of the manifestations of systemic microangiopathy in diabetes. The clinical features are proteinuria, progressive renal damage, hypertension, edema, and severe renal failure in the late stage. . The disease is also one of the leading causes of death in diabetic patients. [0003] Currently, there is no effective treatment for diabetic nephropathy. The vast majority of patients with nephrotic syndrome should not be treated with glucocorticoids, and the trea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P3/10A61P13/12
Inventor 刘永红
Owner DONGGUAN ZHIJIAN MEDICAL TECH
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