Method for preparing levodopa by using Mucuna pruriens

A technology of levodopa and cat beans, which is applied in the field of cat beans processing and preparation of levodopa, can solve the problems of low purity of levodopa, low extraction rate, complicated procedures, etc., to improve extraction rate, reduce energy consumption, shorten The effect of processing time

Inactive Publication Date: 2015-05-13
黄振忠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, the use of cat beans to process and produce levodopa generally has the defects of complicated procedures, low extraction rate, and low purity of levodopa.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: a kind of litsea cubeba oil processing method, concrete steps are as follows:

[0018] 1. Impurity removal and crushing: the raw cat bean is cleaned of impurities, and then crushed into 50 mesh cat bean powder;

[0019] 2. Acid water extraction: Add the crushed cat beans to the extraction equipment, add water according to the ratio of raw materials and water 1:2.5, adjust the pH value to 3, extract for 5 hours, extract twice, and combine the extracts ;

[0020] 3. Concentration: the extract is introduced into the concentration equipment for concentration under reduced pressure, the control temperature is ≤55°C, the vacuum degree is ≥0.09MPa, and concentrated into an extract of 9 Baume degrees;

[0021] 4. Extraction: Add the concentrated extract into the extraction equipment, add ethanol with a concentration of 85% of 120 times the weight of the raw cat beans, and add inorganic salts, stir, and stand for 1.5 hours to form two phases to obtain the upper ph...

Embodiment 2

[0025] Embodiment 2: a kind of litsea cubeba oil processing method comprises the following steps

[0026] 1. Impurity removal and crushing: the raw cat beans are crushed into 60-mesh cat bean powder after removing impurities;

[0027] 2. Acid water extraction: Add the crushed cat beans to the extraction equipment, add water according to the ratio of raw materials and water 1:2.5, adjust the pH value to 3.3, extract for 5 hours, extract twice, and combine the extracts ;

[0028] 3. Concentration: the extract is introduced into the concentration equipment for concentration under reduced pressure, the control temperature is ≤55°C, the vacuum degree is ≥0.09MPa, and concentrated into an extract of 9.5 degrees Baume;

[0029] 4. Extraction: Add the concentrated extract into the extraction equipment, add ethanol with a concentration of 85% at 150 times the weight of the raw cat beans, and add inorganic salts, stir, and stand for 2 hours to form two phases to obtain the upper phase...

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PUM

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Abstract

The invention discloses a method for preparing levodopa by using Mucuna pruriens and belongs to the technical field of drug production and processing. The method specifically comprises the following seven steps: removing impurities and crushing; extracting by acid water; concentrating; extracting; decoloring; crystallizing; and drying. The method has the beneficial effects that the extraction rate of levodopa can be improved by over 1.2%, the purity reaches 89.3%, the processing time is shortened and the energy consumption is reduced.

Description

technical field [0001] The invention relates to the processing of agricultural by-products, in particular to a method for preparing levodopa by processing cat beans, belonging to the technical field of agricultural and by-product processing. Background technique [0002] Cat bean, also known as dog claw bean, white quinoa bean, and dog jump bean, is the seed of the legume family Chenopodium genus Longclaw quinoa bean. Its origin is South Asia, and it is also distributed in southwest my country and South China at an altitude of 800-1400 meters. , Guangxi is the main production area. Cat beans contain natural levodopa, which has important application value. [0003] Levodopa is a drug for the treatment of Parkinson's disease. It is an intermediate product of catecholamines formed from tyrosine, which is the precursor of dopamine. The essence of Parkinson's disease is the death of neurons that can secrete dopamine in the patient's brain, resulting in a lack of dopamine in the b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C229/36C07C227/40
Inventor 黄振忠
Owner 黄振忠
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