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Markers and methods for assessing the toxic effects of atmospheric fine particulate matter exposure on organisms

A technology of atmospheric fine particles and toxic effects, applied in measurement devices, instruments, scientific instruments, etc., can solve problems such as complex effects on the metabolic system of organisms, and achieve the effect of convenient, simple and accurate judgment.

Inactive Publication Date: 2018-01-16
江苏普瑞姆纳米科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Moreover, PM2.5 fine particles contain not only heavy metals, polycyclic aromatic hydrocarbons, and volatile organic compounds, but also organic carbon, elemental carbon, etc. The influence of the influence is very complex, and the existing biological theories and methods have exposed great limitations in terms of analytical throughput

Method used

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  • Markers and methods for assessing the toxic effects of atmospheric fine particulate matter exposure on organisms

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0027] sample collection

[0028] This application collected serum samples from two groups of people. The first group of people (n=230) lived in areas heavily polluted by pm2.5 (240 days of pm2.5 concentration>150μg / m per year) 3 ), the second group of people (n=210) live in areas with low PM2.5 pollution (there are 10 days of PM2.5 concentration>25μg / m 3 ) area. 80% of the random samples (the first group n=184; the second group n=168) in each crowd set up a statistical model, and the remaining 20% ​​samples (the first group n=46; the second group n =42) as a validation sample.

[0029] UPLC-oa-TOF-MS conditions

[0030] The serum metabolic profile was obtained by Ultimate-3000 liquid chromatography coupled with MicrOTOF-Q II-quadrupole time-of-flight mass spectrometry system. A Phenomenex C18 chromatographic column with a packing pore size of 2.1×100 mm and 1.7 μm was used for reversed-phase separation, the column temperature was maintained at 35° C., and the injection vo...

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Abstract

The present invention relates to a marker and method for assessing the toxic effect of air fine particle exposure on organisms, the markers include dihydrosphingosine, phytosphingosine, stearoylphosphatidylcholine, linolenoylglyceryl- One or more of 3-phosphorylcholine, linolenoylglyceryl-4-phosphorylcholine, palmitamide, valine, cytosine, the present invention can more comprehensively and comprehensively reflect the exposure of atmospheric fine particles The change status of metabolites is suitable for the assessment of the toxic effects of atmospheric fine particulate matter exposure.

Description

technical field [0001] The invention relates to a marker and a method for assessing the toxic effect of atmospheric fine particle exposure on organisms, and belongs to the field of detection of atmospheric fine particle toxicity. Background technique [0002] In my country, atmospheric fine particulate matter (PM2.5) pollution is the fourth health risk factor, followed by high blood pressure, smoking and poor eating habits. Fine particulate matter PM2.5 refers to suspended particulate matter with an aerodynamic diameter of less than 2.5 μm in the atmosphere. Compared with coarser atmospheric particulate matter, PM2.5 has a smaller particle size, a larger specific surface area, and more harmful substances adsorbed. Long residence time and long transport distance make it easier to enter the alveoli and stay deep in the lungs, which is not easy to be excreted by the human body, so it has a greater impact on the quality of the atmospheric environment and human health. According...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N15/00G01N30/02
Inventor 金盛烨张洁
Owner 江苏普瑞姆纳米科技有限公司
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