Application of semen aesculi extract in preparation of pharmaceutical cosmetic

A technology of extracts and sala seeds, applied in the field of cosmeceuticals, can solve the problems of not preparing cosmeceuticals, etc., and achieve the effect of improving blood microcirculation and good curative effect

Active Publication Date: 2015-05-20
WUHAN AIMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no bibliographical report on the preparation of cosmeceuticals as an active ingredient with the extract of Sala seed

Method used

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  • Application of semen aesculi extract in preparation of pharmaceutical cosmetic
  • Application of semen aesculi extract in preparation of pharmaceutical cosmetic
  • Application of semen aesculi extract in preparation of pharmaceutical cosmetic

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Embodiment 1 facial mask

[0025] A facial mask for improving facial blood microcirculation, the active ingredient is the extract of Salsa seed, which contains 86.5% total saponins by weight, and the total saponins contain Aescin A, B, C, D, the components of the mask are:

[0026] Base: Kaolin 30%, Talc 5%, Magnesium Carbonate 1%, Titanium Dioxide 2%, Glycerin 10%, Isopropyl Palmitate 8%, Hydrogenated Jojoba Oil 7%, Fragrance 0.05%, Preservative 0.05%, Balance for purified water.

[0027] Active ingredients: 5% of the total weight of the mask.

[0028] Preparation method: first mix kaolin, talc powder, magnesium carbonate, titanium dioxide with glycerin and part of purified water to make a powdery raw material mixture; heat isopropyl palmitate, hydrogenated jojoba oil and the remaining purified water, mix and emulsify, After cooling to 50°C, add powdery raw material mixture, essence, preservative, aescin, mix well, stir evenly, vacuum defoam, let stand for 48 hours ...

Embodiment 2

[0037] The pharmacodynamics animal experiment that embodiment 2 Sala seed extract is used in cosmetics

[0038] Blood microcirculation is closely related to skin aging, keratinization, and scarring. In order to verify the effect of Sala seed extract on improving blood microcirculation in cosmetics, the following animal experiments were carried out:

[0039] (1) Experimental materials Sala seed extract (prepared by the method in Example 1), aescin A, B, C, D (purity all reaches more than 98%); SD rats, male and female, body weight 200 ±20 grams, license number: SCXK (E) 2008-0004, provided by the Animal Experiment Center of Wuhan University, and used after quarantine.

[0040] (2) The influence of scorpion seed extract on the skin temperature of rats gets 50 SD rats, body weight 200 ± 20 grams, half male and half male, the back hair is cut short, and depilatory agent (6%Na 2 S) Apply it on the back of the rat, the depilated area is 3cm×4cm, and wash it off with warm water afte...

Embodiment 3

[0049] Example 3 The human body evaluation test of the effect of removing scars of the extract of Sala chinensis

[0050] The company recruited 36 trial users to evaluate the scar removal effect of Sala seed extract used in cosmetics.

[0051] (1) There were 36 subjects, the trial period was 30 days, and the overall compliance was 88.9%.

[0052] (2) Use the facial mask prepared in Example 1 every night before going to bed, clean the face thoroughly before use, take out the facial mask and cover it on the face, press gently to make the facial mask fully contact with the facial skin, and take off the facial mask after 20 minutes.

[0053] (4) Short-term (use for 1 week) scar removal effect (n=32)

[0054] Table 3 The experimental data of the short-term effect of removing scars from the extract of Sala chinensis

[0055]

[0056] (5) Long-term (use for 1 month) scar removal effect (n=32)

[0057] The test data of the long-term effect of removing scar of table 4 Sala seed e...

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Abstract

The invention discloses application of a semen aesculi extract in preparation of a pharmaceutical cosmetic, and further discloses a pharmaceutical cosmetic. An active component of the pharmaceutical cosmetic is the semen aesculi extract; and the pharmaceutical cosmetic is capable of improving blood microcirculation. A pharmacodynamic test proves that the semen aesculi extract is capable of heating local skin temperature of rats, increasing auricle microcirculation in rats, expanding blood capillaries, and accelerating blood flow rate; and a human evaluation test result proves that the pharmaceutical cosmetic prepared from the semen aesculi extract as the active component has a significant scar removal effect, so that the semen aesculi extract is a safe, effective and reliable pharmaceutical cosmetic material.

Description

technical field [0001] The invention belongs to the field of cosmetics, and in particular relates to the use of a sala seed extract in the preparation of medical cosmetics and a drug cosmetic with the sala seed extract as an active ingredient. Background technique [0002] Salazi, also known as Suluozi, Lingluozi, pistachio, is the drying of Aesculus chinensis Bge., Zhejiang Aesculus chinensis Bge.var.chekingensis (Hu et Fang) Fang Aesculus Wilsonii Rehd. mature seeds. The main active ingredient in Sala seed is total aescin. At present, a variety of saponins have been isolated from the extract of Sala seed. For example, "Chinese Pharmacopoeia" separates four kinds of saponins according to the peak of aescin liquid chromatography. The compounds were named aescin A, aescin B, aescin C and aescin D in turn. Among them, aescin A and B are β-type aescins, and their structures are basically the same, so they can be combined and expressed by structural formula (1); and aescin C a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/97A61K8/63A61K36/185A61Q19/00A61P9/00A61P17/12
Inventor 石召华陈立军黄文芳倪婷婷叶利春
Owner WUHAN AIMIN PHARMA
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