Antibacterial hand sanitizer and preparation method thereof

An antibacterial hand sanitizer and the technology of betel leaves, which are applied in local antibacterial agents, pharmaceutical formulas, cosmetic preparations, etc., can solve the problems of weak antibacterial effect of volatile oil of betel leaves, achieve excellent antibacterial activity, and expand the effect of antibacterial range

Active Publication Date: 2017-11-21
HAINAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The water extract of betel leaf and the water extract of alcohol extract have obvious antibacterial effect on Staphylococcus aureus, Staphylococcus albus, Escherichia coli, Proteus, Salmonella typhi, Bacillus subtilis and some fungi in test tubes, and the antibacterial active ingredients It may be the betel phenol contained in it, but the antibacterial effect of the volatile oil of betel leaves is weak

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0021] This example is the preparation of betel leaf volatile oil, and the specific method is as follows:

[0022] Soak 100g of dried and crushed betel leaves in 800mL of mixed solvent composed of absolute ethanol and petroleum ether (volume ratio of absolute ethanol and petroleum ether is 7:3) at ambient temperature for 72h, filter, and the filtrate is Concentrate under reduced pressure at a temperature of ℃, distill the concentrated solution with water until no oil drops are distilled out, extract the distillate three times with 200mL of anhydrous ether, dry the extract with anhydrous sodium sulfate, and concentrate to obtain 2.6g of yellow oil Betel leaves volatile oil.

example 2～ example 8）

[0024] The preparation method of each example is basically the same as Example 1, and the differences are shown in Table 1.

[0025] Table 1

[0026]

Embodiment 1）

[0028] The antibacterial hand sanitizer of the present embodiment is made by the component of following consumption:

[0029] 0.1g of EDTA-2Na, 8g of AES, 2.3g of LAS, 1.2g of lanolin, 1.5g of 6501, 8g of CAB-35, 4g of glycerol, 1.5g of sodium chloride, 0.001g of pigment , The betel leaf volatile oil that 0.8g example 1 makes, fills up 100g with water.

[0030] The preparation method of this antibacterial hand sanitizer has the following steps:

[0031] ①According to the above formula, first add EDTA-2Na into water, heat to 80°C to dissolve all EDTA-2Na.

[0032] ② Then, add AES at a temperature of 80°C and continue heating to 85°C.

[0033] ③ Next, add LAS at a temperature of 85°C. After the LAS is completely dissolved, add lanolin, 6501, CAB-35, glycerol, and sodium chloride in sequence.

[0034] ④Finally, after all the sodium chloride is dissolved, cool down to 40°C-50°C, add betel leaf volatile oil and pigment, and mix to obtain antibacterial hand sanitizer.

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PUM

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Abstract

The invention discloses an antibacterial hand sanitizer and a preparation method thereof. The antibacterial hand sanitizer is made of the following components in percentage by weight: 0.1-0.2% disodium edetate, 8-10% fatty alcohol Sodium polyoxyethylene ether sulfate, 2.3-2.5% linear alkylbenzene sulfonic acid sodium salt, 1.0-1.2% lanolin, 1.5-2.0% coconut oil fatty acid diethanolamide, 7-8% cocamide Propyl betaine, 3-5% glycerol, 1.5-2.5% sodium chloride, 0.5-1.0% betel leaf volatile oil, 0-0.003% pigment, and the balance is water. By selecting a suitable mixed solvent, the present invention finally obtains the volatile oil of betel leaves whose antibacterial effect is better than that of extracts such as betel leaf ethanol, which overcomes the technical prejudice in this field. By adding the volatile oil of betel leaves to hand sanitizer, antibacterial Antibacterial hand sanitizer with better effect and wider antibacterial range.

Description

technical field [0001] The invention relates to an antibacterial hand sanitizer and a preparation method thereof, in particular to an antibacterial hand sanitizer containing betel leaf volatile oil and a preparation method thereof. Background technique [0002] Hand sanitizer is an essential cleaning tool in people's daily life. As the pollution of human living environment becomes more and more serious, traditional degreasing hand sanitizer is gradually replaced by antibacterial hand sanitizer with sterilization and disinfection functions. However, there are deficiencies such as narrow antibacterial range and poor antibacterial effect in the antibacterial hand sanitizers currently on the market. [0003] Piper betel is a common perennial vine of the family Piper in southern my country. Its root, seed, leaf all can be used as medicine, folks are used for treating various skin diseases. Betel leaves are often chewed with betel nuts and used as condiments. [0004] "Foreign ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/92A61Q19/10A61P31/02
Inventor 纪明慧陈光英郭飞燕吕纪行董立玮
Owner HAINAN NORMAL UNIV
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