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Compound lucid ganoderma extract pellets and preparation method thereof

A technology of Ganoderma lucidum extract and pellets, which is applied in the field of medicine and food, and achieves the effects of high bioavailability, rapid onset of action, and large dispersion area

Inactive Publication Date: 2015-06-03
JF PHARMALAND TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Ganoderma lucidum extract and lycopene have many single health products, but there is no report about the compound preparation of the two. Hongsu’s products are well recognized by consumers. Except for unilateral preparations, these products are basically ordinary tablets and capsules, but the above-mentioned dosage forms have a long disintegration time; they disintegrate at a certain point in the body, Some irritation to gastric mucosa; low bioavailability and other disadvantages

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take the following ingredients for the recipe

[0032] Ganoderma Extract 15g (based on pure product) Lycopene 1g Crystalline Cellulose 80g Hydroxypropylmethylcellulose 4g

[0033] Prepare pellet formulations as follows:

[0034] (1) Take the ganoderma lucidum extract and lycopene in the above formula, add the crystal cellulose, grind to the micronization level with a ball mill, and mix well;

[0035] (2) Dissolve hydroxypropyl methylcellulose in 75% ethanol solution;

[0036] (3) Micro-pills are made by extrusion-spheronization into pellets.

Embodiment 2

[0038] Take the following ingredients for the recipe

[0039] Ganoderma Extract 10g (based on pure product) Lycopene 3g starch 82g Polyvinylpyrrolidone 5g

[0040] Prepare pellet formulations as follows:

[0041] (1) Take the Ganoderma lucidum extract and lycopene in the amount of the above formula, add it to starch, grind it to a micronized level with a ball mill, and mix well;

[0042] (2) Dissolve the adhesive polyvinylpyrrolidone in water;

[0043] (3) Micro-pills are made by pan-pill method.

Embodiment 3

[0045] Take the following ingredients for the recipe

[0046] Ganoderma Extract 8g (based on pure product) Lycopene 5g sucrose 49g starch 34g Polyvinylpyrrolidone 4g

[0047] Prepare pellet formulations as follows:

[0048] (1) Take the Ganoderma lucidum extract and lycopene in the above formula, add sucrose and starch, grind to micronized level with a ball mill, and mix well;

[0049] (2) Dissolve polyvinylpyrrolidone in an appropriate amount of water;

[0050] (3) Using the centrifugal-fluidized pelleting method to make pellets.

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PUM

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Abstract

The invention provides a compound lucid ganoderma extract pellet preparation. The pellet preparation is prepared from a lucid ganoderma extract, lycopene and pharmaceutical adjuvants and is characterized in that the pharmaceutical adjuvants include an excipient and an adhesive; the weight percentages of the lucid ganoderma extract, lycopene, excipient and adhesive in the pellet preparation are respectively 5-20%, 1-5%, 70-85% and 1-5%. The pellet preparation has high dissolution rate and bioavailability. A preparation method is simple and convenient and is easy to operate.

Description

Technical field: [0001] The invention relates to the technical field of medicine and food, in particular to a pellet made from compound ganoderma lucidum extract and a preparation method thereof. Background technique: [0002] There are many unilateral health products of Ganoderma lucidum extract and lycopene, but there is no report about the compound preparation of the two. At present, products about Ganoderma lucidum extract and lycopene are well received by consumers. Except for unilateral preparations, they are basically ordinary tablets and capsules, but the above-mentioned dosage forms have disadvantages such as long disintegration time; disintegration at a certain point in the body, which has certain irritation to gastric mucosa; low bioavailability, etc. . Based on the above problems, we introduced the rapid development of micropill technology in the field of medicine to the field of food, and made this product into a compound micropill product with controllable r...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/074A61K9/16A23L1/28A23L1/29A23P1/00A61K31/01A23L31/00A23P10/00
Inventor 不公告发明人
Owner JF PHARMALAND TECH DEV
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